The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis (Q30524831)

13 October 2017

The transcription factor TFEB links mTORC1 signaling to transcriptional control of lysosome homeostasis (English)

1 reference

mechanistic target of rapamycin kinase

13 October 2017

1 reference

Transcription factor binding to IGHM enhancer 3

1 reference

Transcription factor EB

1 reference

nucleus localization

1 reference

3

Florian Froehlich

1 reference

13 October 2017

Agnes Roczniak-Ferguson

1

1 reference

13 October 2017

Constance S Petit

2

1 reference

13 October 2017

Sharon Qian

4

1 reference

13 October 2017

Jennifer Ky

5

1 reference

13 October 2017

Brittany Angarola

6

1 reference

13 October 2017

Tobias C Walther

7

1 reference

13 October 2017

Shawn M Ferguson

8

1 reference

13 October 2017

12 June 2012

1 reference

13 October 2017

1 reference

13 October 2017

5

1 reference

13 October 2017

228

1 reference

13 October 2017

ra42

1 reference

describes a project that uses

13 October 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3437338/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

1 reference

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Subversion of membrane transport pathways by vacuolar pathogens

20 June 2018

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mTORC1 senses lysosomal amino acids through an inside-out mechanism that requires the vacuolar H(+)-ATPase

20 June 2018

1 reference

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Rapamycin passes the torch: a new generation of mTOR inhibitors

20 June 2018

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20 June 2018

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Transcriptional activation of lysosomal exocytosis promotes cellular clearance

20 June 2018

1 reference

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Regulation of TFEB and V-ATPases by mTORC1.

20 June 2018

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The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling.

20 June 2018

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TFEB links autophagy to lysosomal biogenesis

20 June 2018

1 reference

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20 June 2018

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

20 June 2018

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mTOR: from growth signal integration to cancer, diabetes and ageing

20 June 2018

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Lysosomal accumulation of mTOR is enhanced by rapamycin

20 June 2018

1 reference

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20 June 2018

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20 June 2018

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20 June 2018

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1

20 June 2018

1 reference

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Autophagy gone awry in neurodegenerative diseases

20 June 2018

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

20 June 2018

1 reference

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Termination of autophagy and reformation of lysosomes regulated by mTOR

20 June 2018

1 reference

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20 June 2018

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

20 June 2018

1 reference

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20 June 2018

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A genome-wide screen for genes affecting eisosomes reveals Nce102 function in sphingolipid signaling

20 June 2018

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A gene network regulating lysosomal biogenesis and function

20 June 2018

1 reference

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Molecular mechanisms of mTOR-mediated translational control

20 June 2018

1 reference

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The novel lipid raft adaptor p18 controls endosome dynamics by anchoring the MEK-ERK pathway to late endosomes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

20 June 2018

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20 June 2018

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Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

20 June 2018

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A quantitative atlas of mitotic phosphorylation

20 June 2018

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Regulation of TORC1 by Rag GTPases in nutrient response

20 June 2018

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Autophagy induction and autophagosome clearance in neurons: relationship to autophagic pathology in Alzheimer's disease

20 June 2018

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20 June 2018

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

20 June 2018

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Autophagy in the Pathogenesis of Disease

20 June 2018

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20 June 2018

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20 June 2018

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MITF: master regulator of melanocyte development and melanoma oncogene

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Microphthalmia-associated transcription factor interactions with 14-3-3 modulate differentiation of committed myeloid precursors

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization

20 June 2018

1 reference

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20 June 2018

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Mitf and Tfe3: members of a b-HLH-ZIP transcription factor family essential for osteoclast development and function

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Upregulation of the transcription factor TFEB in t(6;11)(p21;q13)-positive renal cell carcinomas due to promoter substitution

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Identification of a conserved motif required for mTOR signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Caspase cleavage of initiation factor 4E-binding protein 1 yields a dominant inhibitor of cap-dependent translation and reveals a novel regulatory motif

20 June 2018

1 reference

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Linking osteopetrosis and pycnodysostosis: regulation of cathepsin K expression by the microphthalmia transcription factor family

20 June 2018

1 reference

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A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

c-Kit triggers dual phosphorylations, which couple activation and degradation of the essential melanocyte factor Mi.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Ser298 of MITF, a mutation site in Waardenburg syndrome type 2, is a phosphorylation site with functional significance

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

The bHLH-Zip transcription factor Tfeb is essential for placental vascularization

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

The structural basis for 14-3-3:phosphopeptide binding specificity

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

The recessive phenotype displayed by a dominant negative microphthalmia-associated transcription factor mutant is a result of impaired nucleation potential

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

A helix-loop-helix protein related to the immunoglobulin E box-binding proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3437338

Metagrowth: a new resource for the building of metabolic hypotheses in microbiology

20 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002790

CDC25B mediates rapamycin-induced oncogenic responses in cancer cells.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCISIGNAL.2002790

Biology and clinical relevance of the micropthalmia family of transcription factors in human cancer

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22692423

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

microphthalmia, a critical factor in melanocyte development, defines a discrete transcription factor family

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22692423

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCISIGNAL.2002790

1 reference

13 October 2017

1 reference

13 October 2017

PubMed publication ID

22692423

1 reference