Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice (Q30530610)

19 October 2017

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice (English)

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19 October 2017

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Coralie Fassier

1

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ORCID Public Data File 2021

Judith Melki

13

object named as

Judith Melki

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19 October 2017

Anne Tarrade

2

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19 October 2017

Leticia Peris

3

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19 October 2017

Sabrina Courageot

4

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19 October 2017

Philippe Mailly

5

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19 October 2017

Cécile Dalard

6

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19 October 2017

Stéphanie Delga

7

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19 October 2017

Natacha Roblot

8

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19 October 2017

Julien Lefèvre

9

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19 October 2017

Didier Job

10

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19 October 2017

Jamilé Hazan

11

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19 October 2017

Patrick A Curmi

12

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19 October 2017

language of work or name

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5 July 2012

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Disease Models & Mechanisms

19 October 2017

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19 October 2017

6

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19 October 2017

1

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19 October 2017

72-83

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Creative Commons Attribution 2.0 Generic

19 October 2017

start time

18 May 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3529340/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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Hereditary spastic paraplegias: membrane traffic and the motor pathway

20 June 2018

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Genetic and chemical modulation of spastin-dependent axon outgrowth in zebrafish embryos indicates a role for impaired microtubule dynamics in hereditary spastic paraplegia

20 June 2018

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Tubulin polyglutamylation stimulates spastin-mediated microtubule severing

20 June 2018

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Evaluation of loss of function as an explanation for SPG4-based hereditary spastic paraplegia

20 June 2018

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Hereditary spastic paraplegia proteins REEP1, spastin, and atlastin-1 coordinate microtubule interactions with the tubular ER network

20 June 2018

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Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia

20 June 2018

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Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules

20 June 2018

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Motor-dependent microtubule disassembly driven by tubulin tyrosination

20 June 2018

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Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients

20 June 2018

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Hereditary spastic paraplegia: clinical features and pathogenetic mechanisms

20 June 2018

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Spastin couples microtubule severing to membrane traffic in completion of cytokinesis and secretion

20 June 2018

1 reference

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Quantitative and functional analyses of spastin in the nervous system: implications for hereditary spastic paraplegia

20 June 2018

1 reference

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Microtubule stabilization specifies initial neuronal polarization

20 June 2018

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The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches

20 June 2018

1 reference

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Structural basis of microtubule severing by the hereditary spastic paraplegia protein spastin

20 June 2018

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20 June 2018

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Recognition of C-terminal amino acids in tubulin by pore loops in Spastin is important for microtubule severing

20 June 2018

1 reference

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Exon deletions of SPG4 are a frequent cause of hereditary spastic paraplegia

20 June 2018

1 reference

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Tubulin tyrosination is a major factor affecting the recruitment of CAP-Gly proteins at microtubule plus ends.

20 June 2018

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20 June 2018

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Human spastin has multiple microtubule-related functions

20 June 2018

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Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus

20 June 2018

1 reference

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The Drosophila homologue of the hereditary spastic paraplegia protein, spastin, severs and disassembles microtubules

20 June 2018

1 reference

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Neuronal microtubules: when the MAP is the roadblock

20 June 2018

1 reference

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Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing

20 June 2018

1 reference

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Drosophila spastin regulates synaptic microtubule networks and is required for normal motor function

20 June 2018

1 reference

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Microtubule dynamics are necessary for SRC family kinase-dependent growth cone steering.

20 June 2018

1 reference

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Axonal growth is sensitive to the levels of katanin, a protein that severs microtubules

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Microtubules as a target for anticancer drugs

20 June 2018

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Science in motion: common molecular pathological themes emerge in the hereditary spastic paraplegias

20 June 2018

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Mutations of SPG4 are responsible for a loss of function of spastin, an abundant neuronal protein localized in the nucleus

20 June 2018

1 reference

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A role for regulated binding of p150(Glued) to microtubule plus ends in organelle transport

20 June 2018

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Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Nuclear targeting defect of SMN lacking the C-terminus in a mouse model of spinal muscular atrophy

20 June 2018

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Spectrum of SPG4 mutations in autosomal dominant spastic paraplegia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Membrane traffic and the cellular uptake of cholera toxin

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Nanomolar concentrations of nocodazole alter microtubule dynamic instability in vivo and in vitro.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Accumulation of delta 2-tubulin, a major tubulin variant that cannot be tyrosinated, in neuronal tissues and in stable microtubule assemblies.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

The role of microtubule dynamics in growth cone motility and axonal growth

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Mechanism of inhibition of cell proliferation by Vinca alkaloids.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

CLIP-170 links endocytic vesicles to microtubules

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Pleiotropic effects of spastin on neurite growth depending on expression levels

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

The microtubule-severing protein Spastin is essential for axon outgrowth in the zebrafish embryo

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Spastin in the human and mouse central nervous system with special reference to its expression in the hippocampus of mouse pilocarpine model of status epilepticus and temporal lobe epilepsy.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

CLIPs for organelle-microtubule interactions

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein).

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

A simple procedure for quantification of neurite outgrowth based on stereological principles.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3529340

26 November 2018

Microtubules cut and run

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22773755

12 December 2020

inferred from PubMed ID database lookup

Spastin interacts with the centrosomal protein NA14, and is enriched in the spindle pole, the midbody and the distal axon

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22773755

12 December 2020

inferred from PubMed ID database lookup

Hereditary spastic paraplegia

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22773755

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1242/DMM.008946

1 reference

19 October 2017

1 reference

19 October 2017

PubMed publication ID

22773755

1 reference