A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity (Q30838501)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096355%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

title

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity (English)

1 reference

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10 April 2020

1 reference

1 reference

corrigendum / erratum

Correction for Perni et al., A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

0 references

author

Celine Galvagnion

2

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10 April 2020

Georg Meisl

4

1 reference

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10 April 2020

Julius B. Kirkegaard

7

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10 April 2020

Patrick Flagmeier

8

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10 April 2020

Serene W Chen

11

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10 April 2020

Ryan Limbocker

12

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10 April 2020

Pietro Sormanni

13

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Gabriella Heller

14

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Francesco Antonio Aprile

15

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10 April 2020

Cristina Cecchi

17

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10 April 2020

Tuomas Knowles

20

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10 April 2020

Michele Vendruscolo

21

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Nunilo Cremades

16

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Chris Dobson

24

object named as

Christopher M Dobson

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10 April 2020

10

Roberta Cascella

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10 April 2020

19

Ellen A A Nollen

1 reference

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10 April 2020

author name string

Michele Perni

1

1 reference

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10 April 2020

Alexander Maltsev

3

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10 April 2020

Martin B D Müller

5

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10 April 2020

Pavan K Challa

6

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10 April 2020

Samuel I A Cohen

9

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10 April 2020

Fabrizio Chiti

18

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10 April 2020

Adriaan Bax

22

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10 April 2020

Michael Zasloff

23

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10 April 2020

language of work or name

English

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publication date

17 January 2017

1 reference

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Proceedings of the National Academy of Sciences of the United States of America

10 April 2020

published in

1 reference

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10 April 2020

volume

114

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issue

6

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10 April 2020

page(s)

E1009-E1017

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describes a project that uses

10 April 2020

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5307473/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Mutations associated with familial Parkinson's disease alter the initiation and amplification steps of α-synuclein aggregation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

An anticancer drug suppresses the primary nucleation reaction that initiates the production of the toxic Aβ42 aggregates linked with Alzheimer's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

New insights into cellular α-synuclein homeostasis in health and disease.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Structural characterization of toxic oligomers that are kinetically trapped during α-synuclein fibril formation.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Efficient modification of alpha-synuclein serine 129 by protein kinase CK1 requires phosphorylation of tyrosine 125 as a priming event

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

The amyloid state and its association with protein misfolding diseases.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Solution conditions determine the relative importance of nucleation and growth processes in α-synuclein aggregation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Proliferation of amyloid-β42 aggregates occurs through a secondary nucleation mechanism

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Keeping track of worm trackers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Impact of N-terminal acetylation of α-synuclein on its random coil and lipid binding properties

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Direct observation of the interconversion of normal and toxic forms of α-synuclein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Α-synuclein misfolding and Parkinson's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Squalamine as a broad-spectrum systemic antiviral agent with therapeutic potential

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Membrane surface charge dictates the structure and function of the epithelial Na+/H+ exchanger

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Targeted amino-terminal acetylation of recombinant proteins in E. coli

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Identification of MOAG-4/SERF as a regulator of age-related proteotoxicity.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Destabilizing protein polymorphisms in the genetic background direct phenotypic expression of mutant SOD1 toxicity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Membrane phosphatidylserine regulates surface charge and protein localization

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Molecular anatomy of a trafficking organelle

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

The aggregation and fibrillation of alpha-synuclein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Opposing activities protect against age-onset proteotoxicity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Protein misfolding, functional amyloid, and human disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

NMR of alpha-synuclein-polyamine complexes elucidates the mechanism and kinetics of induced aggregation.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Molecular Pathways of Neurodegeneration in Parkinson's Disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Unfolding the role of protein misfolding in neurodegenerative diseases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Effect of squalamine on iris neovascularization in monkeys

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: implications for Huntington's disease pathology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

alpha-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with lewy bodies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Squalamine: an aminosterol antibiotic from the shark

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Expression of human beta-amyloid peptide in transgenic Caenorhabditis elegans

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

The genetics of Caenorhabditis elegans

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5307473

Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression

14 July 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Squalamine is not a proton ionophore.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Effects of Parkinson's disease-linked mutations on the structure of lipid-associated alpha-synuclein

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Conformational properties of alpha-synuclein in its free and lipid-associated states

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Investigating macromolecules inside cultured and injected cells by in-cell NMR spectroscopy

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Extracellular chaperones prevent Aβ42-induced toxicity in rat brains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Phosphorylation of Ser-129 is the dominant pathological modification of alpha-synuclein in familial and sporadic Lewy body disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Dependence of alpha-synuclein aggregate morphology on solution conditions

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Detergent-like interaction of Congo red with the amyloid beta peptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.1610586114

Dementia with Lewy bodies

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28096355

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.1610586114

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096355%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28096355%20AND%20SRC:MED&resulttype=core&format=json

10 April 2020

PubMed publication ID

28096355

1 reference