Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models (Q30830788)

20 August 2017

Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models (English)

1 reference

extracellular vesicle in the nervous system

20 August 2017

1 reference

1 reference

based on heuristic

inferred from title

extracellular vesicle

1 reference

14

Mark P Mattson

1 reference

20 August 2017

9

Gregory A Jicha

1 reference

20 August 2017

Erez Eitan

1

1 reference

20 August 2017

Emmette R Hutchison

2

1 reference

20 August 2017

Krisztina Marosi

3

1 reference

20 August 2017

James Comotto

4

1 reference

20 August 2017

Maja Mustapic

5

1 reference

20 August 2017

Saket M Nigam

6

1 reference

20 August 2017

Caitlin Suire

7

1 reference

20 August 2017

Chinmoyee Maharana

8

1 reference

20 August 2017

Dong Liu

10

1 reference

20 August 2017

Vasiliki Machairaki

11

1 reference

20 August 2017

Kenneth W Witwer

12

1 reference

20 August 2017

Dimitrios Kapogiannis

13

1 reference

20 August 2017

22 September 2016

1 reference

NPJ aging and mechanisms of disease

20 August 2017

1 reference

20 August 2017

2

1 reference

Creative Commons Attribution 4.0 International

20 August 2017

start time

22 September 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

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14 July 2018

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Extracellular vesicle-depleted fetal bovine and human sera have reduced capacity to support cell growth

14 July 2018

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Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles

14 July 2018

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Emerging roles of extracellular vesicles in the nervous system

14 July 2018

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Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles

14 July 2018

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Tetraspanins in extracellular vesicle formation and function

14 July 2018

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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

14 July 2018

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Decreased amyloid-β pathologies by intracerebral loading of glycosphingolipid-enriched exosomes in Alzheimer model mice

14 July 2018

1 reference

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Induced pluripotent stem cells from familial Alzheimer's disease patients differentiate into mature neurons with amyloidogenic properties

14 July 2018

1 reference

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Alzheimer's disease genetics: from the bench to the clinic

14 July 2018

1 reference

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Serial propagation of distinct strains of Aβ prions from Alzheimer's disease patients

14 July 2018

1 reference

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Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

14 July 2018

1 reference

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Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

14 July 2018

1 reference

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Exosomes neutralize synaptic-plasticity-disrupting activity of Aβ assemblies in vivo

14 July 2018

1 reference

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Standardization of sample collection, isolation and analysis methods in extracellular vesicle research

14 July 2018

1 reference

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Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats

14 July 2018

1 reference

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Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

14 July 2018

1 reference

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Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis

14 July 2018

1 reference

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Deciphering the mechanism underlying late-onset Alzheimer disease

14 July 2018

1 reference

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The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Fiji: an open-source platform for biological-image analysis

14 July 2018

1 reference

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Purified and synthetic Alzheimer's amyloid beta (Aβ) prions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Syndecan-syntenin-ALIX regulates the biogenesis of exosomes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Microvesicles: novel biomarkers for neurological disorders

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Sphingolipid-modulated exosome secretion promotes clearance of amyloid-β by microglia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Structural basis for increased toxicity of pathological aβ42:aβ40 ratios in Alzheimer disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Exosome-associated tau is secreted in tauopathy models and is selectively phosphorylated in cerebrospinal fluid in early Alzheimer disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Alzheimer's disease pathologic cascades: who comes first, what drives what

14 July 2018

1 reference

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Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease

14 July 2018

1 reference

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The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

14 July 2018

1 reference

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Protein targeting to exosomes/microvesicles by plasma membrane anchors

14 July 2018

1 reference

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Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes

14 July 2018

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Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

14 July 2018

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Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

14 July 2018

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival

14 July 2018

1 reference

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Molecular mechanisms of neurodegeneration in Alzheimer's disease

14 July 2018

1 reference

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The transcellular spread of cytosolic amyloids, prions, and prionoids

14 July 2018

1 reference

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Insulin-degrading enzyme sorting in exosomes: a secretory pathway for a key brain amyloid-beta degrading protease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementia

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Cystatin C is released in association with exosomes: a new tool of neuronal communication which is unbalanced in Alzheimer's disease.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Mitochondria in neuroplasticity and neurological disorders

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Amyloid precursor protein trafficking, processing, and function

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

The autophagy-related protein beclin 1 shows reduced expression in early Alzheimer disease and regulates amyloid beta accumulation in mice

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Accelerated release of exosome-associated GM1 ganglioside (GM1) by endocytic pathway abnormality: another putative pathway for GM1-induced amyloid fibril formation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Intracellular pH regulates amyloid precursor protein intracellular domain accumulation.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Alzheimer's disease beta-amyloid peptides are released in association with exosomes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Pathways towards and away from Alzheimer's disease

14 July 2018

1 reference

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Cells release prions in association with exosomes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

The role of the endosomal/lysosomal system in amyloid-beta production and the pathophysiology of Alzheimer's disease: reexamining the spatial paradox from a lysosomal perspective.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Mast cell- and dendritic cell-derived exosomes display a specific lipid composition and an unusual membrane organization.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Intraneuronal Alzheimer abeta42 accumulates in multivesicular bodies and is associated with synaptic pathology

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin 1 and amyloid precursor proteins

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

The vacuolar H(+)-ATPase inhibitor bafilomycin A1 differentially affects proteolytic processing of mutant and wild-type beta-amyloid precursor protein

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Increased Abeta production leads to intracellular accumulation of Abeta in flotillin-1-positive endosomes

14 July 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPJAMD.2016.19

A potential function for neuronal exosomes: sequestering intracerebral amyloid-β peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPJAMD.2016.19

Oligomeric proteins ultrastructurally localize to cell processes, especially to axon terminals with higher density, but not to lipid rafts in Tg2576 mouse brain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPJAMD.2016.19

Lipid rafts mediate amyloid-induced calcium dyshomeostasis and oxidative stress in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPJAMD.2016.19

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPJAMD.2016.19

Aβ secretion and plaque formation depend on autophagy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPJAMD.2016.19

The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPJAMD.2016.19

Membrane-bound β-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNPJAMD.2016.19

Additional use of Aβ₄₂/Aβ₄₀ ratio with cerebrospinal fluid biomarkers P-tau and Aβ₄₂ increases the level of evidence of Alzheimer's disease pathophysiological process in routine practice

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5137253

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

25 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27928512

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NPJAMD.2016.19

0 references

Dimensions Publication ID

0 references

1 reference

20 August 2017

PubMed publication ID

27928512

1 reference