Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity (Q30844400)

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English	Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

27 June 2017

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Europe PubMed Central

Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity (English)

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Europe PubMed Central

PubMed publication ID

27 June 2017

1

object named as

Kazuhiro Irie

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PubMed publication ID

27 June 2017

author name string

Akifumi Nakahara

2

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Europe PubMed Central

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27 June 2017

Yu Nakagawa

3

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Europe PubMed Central

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27 June 2017

Hajime Ohigashi

4

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Europe PubMed Central

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27 June 2017

Mayumi Shindo

5

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Europe PubMed Central

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27 June 2017

Hiroyuki Fukuda

6

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Europe PubMed Central

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27 June 2017

Hiroaki Konishi

7

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Europe PubMed Central

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27 June 2017

Ushio Kikkawa

8

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Europe PubMed Central

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27 June 2017

Kaori Kashiwagi

9

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27 June 2017

Naoaki Saito

10

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27 June 2017

publication date

1 February 2002

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27 June 2017

Pharmacology & Therapeutics

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27 June 2017

93

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27 June 2017

2-3

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27 June 2017

271-281

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27 June 2017

Structural studies of reagents for peptide bond formation: Crystal and molecular structures of HBTU and HATU

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1-Hydroxy-7-azabenzotriazole. An efficient peptide coupling additive

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Clarification of the binding mode of teleocidin and benzolactams to the Cys2 domain of protein kinase Cdelta by synthesis of hydrophobically modified, teleocidin-mimicking benzolactams and computational docking simulation

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Solid-phase synthesis, mass spectrometric analysis of the zinc-folding, and phorbol ester-binding studies of the 116-mer peptide containing the tandem cysteine-rich C1 domains of protein kinase C gamma

1 reference

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7 January 2021

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Solution structure of a cysteine rich domain of rat protein kinase C

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7 January 2021

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Identification and characterization of zinc binding sites in protein kinase C.

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Cysteine-rich regions of protein kinase Cdelta are functionally non-equivalent. Differences between cysteine-rich regions of non-calcium-dependent protein kinase Cdelta and calcium-dependent protein kinase Cgamma

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Taxonomy and function of C1 protein kinase C homology domains

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Solution Structure of Cysteine-Rich Domain of Protein Kinase Cα1

1 reference

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7 January 2021

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Synthesis and characterization of the second cysteine-rich region of mouse skin PKCGh

1 reference

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Comparison of chemical characteristics of the first and the second cysteine-rich domains of protein kinase C gamma

1 reference

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Synthesis and phorbol ester-binding studies of the individual cysteine-rich motifs of protein kinase D

1 reference

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Synthesis and tumor-promoting activities of 12-Epi-phorbol-12,13-dibutyrate

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Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor

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Residues in the Second Cysteine-rich Region of Protein Kinase C δ Relevant to Phorbol Ester Binding as Revealed by Site-directed Mutagenesis

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Modeling, chemistry, and biology of the benzolactam analogues of indolactam V (ILV). 2. Identification of the binding site of the benzolactams in the CRD2 activator-binding domain of PKCdelta and discovery of an ILV analogue of improved isozyme sele

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Studying noncovalent protein complexes by electrospray ionization mass spectrometry

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Tumor promotion by depleting cells of protein kinase C delta

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Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma

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Specificity of the fatty acyl moieties of diacylglycerol for the activation of calcium-activated, phospholipid-dependent protein kinase

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7 January 2021

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Synthesis and biological activities of indolactone-V, the lactone analogue of the tumor promoter (-)-indolactam-V

1 reference

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7 January 2021

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Synthesis and PKC isozyme surrogate binding of indothiolactam-V, a new thioamide analogue of tumor promoting indolactam-V

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7258%2802%2900196-1

7 January 2021

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The amide hydrogen of (-)-indolactam-V and benzolactam-V8's plays a critical role in protein kinase C binding and tumor-promoting activities

1 reference

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7 January 2021

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The role of protein kinase C in cell surface signal transduction and tumour promotion

1 reference

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7 January 2021

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Protein kinase C and lipid signaling for sustained cellular responses

1 reference

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7 January 2021

based on heuristic

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Phorbol ester binding to protein kinase C requires a cysteine-rich zinc-finger-like sequence

1 reference

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Isolation and structure of bryostatin 1

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Toward the identification of selective modulators of protein kinase C (PKC) isozymes: establishment of a binding assay for PKC isozymes using synthetic C1 peptide receptors and identification of the critical residues involved in the phorbol ester bi

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Non-equivalent roles for the first and second zinc fingers of protein kinase Cdelta. Effect of their mutation on phorbol ester-induced translocation in NIH 3T3 cells

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NMR structure of a protein kinase C-gamma phorbol-binding domain and study of protein-lipid micelle interactions

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Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester

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10.1016/S0163-7258(02)00196-1

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Europe PubMed Central

PubMed publication ID

27 June 2017

release_3t2trmt56rgkfihzgisl4n4xxa

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24 November 2022

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

27 June 2017

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