SecYEG assembles into a tetramer to form the active protein translocation channel (Q30843286)

20 September 2017

SecYEG assembles into a tetramer to form the active protein translocation channel (English)

1 reference

20 September 2017

E H Manting

1

1 reference

20 September 2017

C van Der Does

2

1 reference

20 September 2017

H Remigy

3

1 reference

20 September 2017

A Engel

4

1 reference

20 September 2017

A J Driessen

5

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20 September 2017

language of work or name

English

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publication date

1 March 2000

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20 September 2017

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20 September 2017

19

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20 September 2017

5

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20 September 2017

852-861

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Preprotein translocation by a hybrid translocase composed of Escherichia coli and Bacillus subtilis subunits.

20 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Functional identification of the product of the Bacillus subtilis yvaL gene as a SecG homologue.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Membrane deinsertion of SecA underlying proton motive force-dependent stimulation of protein translocation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Mass Measurement in the Scanning Transmission Electron Microscope: A Powerful Tool for Studying Membrane Proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Bacterial preprotein translocase: mechanism and conformational dynamics of a processive enzyme.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

The catalytic cycle of the escherichia coli SecA ATPase comprises two distinct preprotein translocation events

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Alignment of conduits for the nascent polypeptide chain in the ribosome-Sec61 complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

In vivo cross-linking of the SecA and SecY subunits of the Escherichia coli preprotein translocase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Topology of the integral membrane form of Escherichia coli SecA protein reveals multiple periplasmically exposed regions and modulation by ATP binding.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Inhibition of preprotein translocation and reversion of the membrane inserted state of SecA by a carboxyl terminus binding mAb.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Distinct catalytic roles of the SecYE, SecG and SecDFyajC subunits of preprotein translocase holoenzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Both an N-terminal 65-kDa domain and a C-terminal 30-kDa domain of SecA cycle into the membrane at SecYEG during translocation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecA is an intrinsic subunit of the Escherichia coli preprotein translocase and exposes its carboxyl terminus to the periplasm.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

A significant fraction of functional SecA is permanently embedded in the membrane. SecA cycling on and off the membrane is not essential during protein translocation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Purified Escherichia coli preprotein translocase catalyzes multiple cycles of precursor protein translocation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecD is involved in the release of translocated secretory proteins from the cytoplasmic membrane of Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

The SecA and SecY subunits of translocase are the nearest neighbors of a translocating preprotein, shielding it from phospholipids

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Subunit dynamics in Escherichia coli preprotein translocase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

A cytoplasmic domain is important for the formation of a SecY-SecE translocator complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecD and SecF are required for the proton electrochemical gradient stimulation of preprotein translocation

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Evolutionary conservation of components of the protein translocation complex

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecF stabilizes SecD and SecY, components of the protein translocation machinery of the Escherichia coli cytoplasmic membrane

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecYEG and SecA Are the Stoichiometric Components of Preprotein Translocase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Genetic and molecular characterization of the Escherichia coli secD operon and its products

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Classification of images of biomolecular assemblies: a study of ribosomes and ribosomal subunits of Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Purified secB protein of Escherichia coli retards folding and promotes membrane translocation of the maltose-binding protein in vitro

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecA protein is required for secretory protein translocation into E. coli membrane vesicles.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Translocation of ProOmpA possessing an intramolecular disulfide bridge into membrane vesicles of Escherichia coli. Effect of membrane energization

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Electrochemical potential releases a membrane-bound secretion intermediate of maltose-binding protein in Escherichia coli

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

The binding cascade of SecB to SecA to SecY/E mediates preprotein targeting to the E. coli plasma membrane

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

The purified E. coli integral membrane protein SecY/E is sufficient for reconstitution of SecA-dependent precursor protein translocation.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

The ATPase activity of SecA is regulated by acidic phospholipids, SecY, and the leader and mature domains of precursor proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecA protein needs both acidic phospholipids and SecY/E protein for functional high-affinity binding to the Escherichia coli plasma membrane

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

ΔμH+ and ATP function at different steps of the catalytic cycle of preprotein translocase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecA, an essential component of the secretory machinery of Escherichia coli, exists as homodimer.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Precursor protein translocation by the Escherichia coli translocase is directed by the protonmotive force

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

Domain interactions of the peripheral preprotein Translocase subunit SecA.

28 July 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

Sec-dependent membrane protein biogenesis: SecYEG, preprotein hydrophobicity and translocation kinetics control the stop-transfer function

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

SecA, the peripheral subunit of the Escherichia coli precursor protein translocase, is functional as a dimer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

SecA promotes preprotein translocation by undergoing ATP-driven cycles of membrane insertion and deinsertion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

The protease-protected 30 kDa domain of SecA is largely inaccessible to the membrane lipid phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

SecA protein is exposed to the periplasmic surface of the E. coli inner membrane in its active state.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

Identification of a region of interaction between Escherichia coli SecA and SecY proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

Oligomeric Rings of the Sec61p Complex Induced by Ligands Required for Protein Translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

Separable ATPase and Membrane Insertion Domains of the SecA Subunit of Preprotein Translocase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FEMBOJ%2F19.5.852

A novel membrane protein involved in protein translocation across the cytoplasmic membrane of Escherichia coli.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

The allele-specific synthetic lethality of prlA-prlG double mutants predicts interactive domains of SecY and SecE.

25 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=305625

SecE-dependent overproduction of SecY in Escherichia coli. Evidence for interaction between two components of the secretory machinery

25 November 2018

1 reference

12 December 2020

The bacterial SecY/E translocation complex forms channel-like structures similar to those of the eukaryotic Sec61p complex

1 reference

12 December 2020

Inversion of the membrane topology of SecG coupled with SecA-dependent preprotein translocation

1 reference

12 December 2020

Interaction between SecA and SecYEG in Micellar Solution and Formation of the Membrane-Inserted State†

1 reference

12 December 2020

Translocase-Bound SecA Is Largely Shielded from the Phospholipid Acyl Chains†

1 reference

12 December 2020

BiP maintains the permeability barrier of the ER membrane by sealing the lumenal end of the translocon pore before and early in translocation

1 reference

12 December 2020

Reconstitution of an efficient protein translocation machinery comprising SecA and the three membrane proteins, SecY, SecE, and SecG (p12)

1 reference

12 December 2020

The aqueous pore through the translocon has a diameter of 40-60 A during cotranslational protein translocation at the ER membrane

1 reference

12 December 2020

Identifiers

DOI

10.1093/EMBOJ/19.5.852

1 reference

20 September 2017

1 reference

20 September 2017

PubMed publication ID

10698927

1 reference