Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways (Q30885679)

27 June 2017

title

Integration of chemical-genetic and genetic interaction data links bioactive compounds to cellular target pathways (English)

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Grant W Brown

7

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author name string

Ainslie B Parsons

1

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Renée L Brost

2

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Huiming Ding

3

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Zhijian Li

4

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Chaoying Zhang

5

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Bilal Sheikh

6

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Patricia M Kane

8

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Timothy R Hughes

9

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Charles Boone

10

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publication date

7 December 2003

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volume

22

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issue

1

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page(s)

62-69

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Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis

27 June 2017

cites work

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7 January 2021

Functional discovery via a compendium of expression profiles

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Drug target validation and identification of secondary drug target effects using DNA microarrays

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Integrating genetic approaches into the discovery of anticancer drugs

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Systematic genetic analysis with ordered arrays of yeast deletion mutants

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7 January 2021

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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7 January 2021

Relationships between sensitivity to hydroxyurea and 4-methyl-5-amino-1-formylisoquinoline thiosemicarbazone (MAIO) and ribonucleotide reductase RNR2 mRNA levels in strains of Saccharomyces cerevisiae.

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7 January 2021

Cloning and characterization of a yeast cytochrome b5-encoding gene which suppresses ketoconazole hypersensitivity in a NADPH-P-450 reductase-deficient strain.

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7 January 2021

TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin

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7 January 2021

Tunicamycin — An inhibitor of yeast glycoprotein synthesis

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7 January 2021

STT4 is an essential phosphatidylinositol 4-kinase that is a target of wortmannin in Saccharomyces cerevisiae

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7 January 2021

Calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, is essential in yeast mutants with cell integrity defects and in mutants that lack a functional vacuolar H(+)-ATPase

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7 January 2021

Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance

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7 January 2021

Drug susceptibilities of yeast cells are affected by membrane lipid composition

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7 January 2021

Characterization of staurosporine-sensitive mutants of Saccharomyces cerevisiae: vacuolar functions affect staurosporine sensitivity

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7 January 2021

Intracellular pH and the control of multidrug resistance

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7 January 2021

The gene encoding vacuolar H(+)-ATPase subunit C is overexpressed in multidrug-resistant HL60 cells

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7 January 2021

Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases.

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7 January 2021

Inhibitors of vacuolar H+-ATPase impair the preferential accumulation of daunomycin in lysosomes and reverse the resistance to anthracyclines in drug-resistant renal epithelial cells.

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7 January 2021

Heat-inducible degron: a method for constructing temperature-sensitive mutants.

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7 January 2021

Genetic analysis of calmodulin and its targets in Saccharomyces cerevisiae

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7 January 2021

Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone

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7 January 2021

Cooperation of calcineurin and vacuolar H(+)-ATPase in intracellular Ca2+ homeostasis of yeast cells

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7 January 2021

Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes

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7 January 2021

Elg1 forms an alternative RFC complex important for DNA replication and genome integrity

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7 January 2021

ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C

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7 January 2021

Characterization of the tubulin-tyrosine ligase

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7 January 2021

Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar-coding strategy

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7 January 2021

Genomic profiling of drug sensitivities via induced haploinsufficiency.

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7 January 2021

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7 January 2021

Mammalian RNAi for the masses

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7 January 2021

Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications

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7 January 2021

Osprey: a network visualization system

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7 January 2021

Gene ontology: tool for the unification of biology

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7 January 2021

MIPS: a database for protein sequences, homology data and yeast genome information

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7 January 2021

The GRID: the General Repository for Interaction Datasets

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7 January 2021

Identifiers

DOI

10.1038/NBT919

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27 June 2017

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