Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases (Q31032457)

28 June 2017

title

Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases (English)

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28 June 2017

author name string

Fiona Grüninger-Leitch

1

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28 June 2017

Daniel Schlatter

2

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28 June 2017

Erich Küng

3

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28 June 2017

Peter Nelböck

4

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28 June 2017

Heinz Döbeli

5

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28 June 2017

language of work or name

English

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publication date

7 December 2001

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Journal of Biological Chemistry

28 June 2017

published in

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volume

277

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28 June 2017

issue

7

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28 June 2017

page(s)

4687-4693

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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

28 June 2017

cites work

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Identification of a Novel Aspartic Protease (Asp 2) as β-Secretase

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

21 January 2018

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Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

21 January 2018

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Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein

21 January 2018

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BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics

21 January 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

21 January 2018

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BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

21 January 2018

1 reference

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ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site

21 January 2018

1 reference

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The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the down critical region

21 January 2018

1 reference

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Structure of the protease domain of memapsin 2 (beta-secretase) complexed with inhibitor

21 January 2018

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Expression analysis of BACE2 in brain and peripheral tissues

21 January 2018

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Recombinant human renin produced in different expression systems: biochemical properties and 3D structure

21 January 2018

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Purification and characterization of active recombinant human napsin A.

21 January 2018

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Identification of beta-secretase-like activity using a mass spectrometry-based assay system

21 January 2018

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Characterization of Alzheimer's beta -secretase protein BACE. A pepsin family member with unusual properties

21 January 2018

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A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta -secretase

21 January 2018

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Processing of beta-secretase by furin and other members of the proprotein convertase family

21 January 2018

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Maturation and pro-peptide cleavage of beta-secretase

21 January 2018

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Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production

21 January 2018

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The pro domain of beta-secretase does not confer strict zymogen-like properties but does assist proper folding of the protease domain

21 January 2018

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Rapid identification of substrates for novel proteases using a combinatorial peptide library

21 January 2018

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Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide

21 January 2018

1 reference

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The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate

21 January 2018

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BACE2 functions as an alternative alpha-secretase in cells

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.M109266200

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28 June 2017

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