Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture (Q31047685)

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English	Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Analysis of beta-cell gene expression reveals inflammatory signaling and evidence of dedifferentiation following human islet isolation and culture (English)

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

5

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

author name string

Sarita Negi

1

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Arif Jetha

2

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Reid Aikin

3

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Craig Hasilo

4

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

Steven Paraskevas

6

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

language of work or name

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publication date

27 January 2012

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

7

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

1

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

e30415

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

copyright license

Creative Commons Attribution 4.0 International

27 January 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

0 references

Kinetics and genomic profiling of adult human and mouse β-cell maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

A systems biological approach to identify key transcription factors and their genomic neighborhoods in human sarcomas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Dachshund homologues play a conserved role in islet cell development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Antiproinflammatory effects of iodixanol (OptiPrep)-based density gradient purification on human islet preparations.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

MafA and MafB regulate genes critical to beta-cells in a unique temporal manner

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

c-Kit and stem cell factor regulate PANC-1 cell differentiation into insulin- and glucagon-producing cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Pancreatic beta cells require NeuroD to achieve and maintain functional maturity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

The emerging role of SOX transcription factors in pancreatic endocrine cell development and function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Epithelial-mesenchymal transition in cells expanded in vitro from lineage-traced adult human pancreatic beta cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Chronology of islet differentiation revealed by temporal cell labeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Pancreatic duct cells in human islet cell preparations are a source of angiogenic cytokines interleukin-8 and vascular endothelial growth factor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

In Vitro Proliferation of Cells Derived From Adult Human -Cells Revealed By Cell-Lineage Tracing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Preferential reduction of beta cells derived from Pax6-MafB pathway in MafB deficient mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Mammalian Gup1, a homolog of Saccharomyces cerevisiae glycerol uptake/transporter 1, acts as a negative regulator for N-terminal palmitoylation of Sonic hedgehog

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Genetic identification of a novel NeuroD1 function in the early differentiation of islet alpha, PP and epsilon cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Loss of Myt1 function partially compromises endocrine islet cell differentiation and pancreatic physiological function in the mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Notch signalling suppresses apoptosis in adult human and mouse pancreatic islet cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Sox9 coordinates a transcriptional network in pancreatic progenitor cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Role of the Onecut transcription factors in pancreas morphogenesis and in pancreatic and enteric endocrine differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

MafB is required for islet beta cell maturation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

SOX9 is required for maintenance of the pancreatic progenitor cell pool

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

The unique cytoarchitecture of human pancreatic islets has implications for islet cell function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

SOX6 attenuates glucose-stimulated insulin secretion by repressing PDX1 transcriptional activity and is down-regulated in hyperinsulinemic obese mice.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

MafA is a key regulator of glucose-stimulated insulin secretion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Central necrosis in isolated hypoxic human pancreatic islets: evidence for postisolation ischemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Epithelial-to-Mesenchymal Transition Generates Proliferative Human Islet Precursor Cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

NF-kappaB: a multifaceted transcription factor regulated at several levels

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Opposing actions of Arx and Pax4 in endocrine pancreas development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Human pancreatic precursor cells secrete FGF2 to stimulate clustering into hormone-expressing islet-like cell aggregates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Isolated human islets trigger an instant blood mediated inflammatory reaction: implications for intraportal islet transplantation as a treatment for patients with type 1 diabetes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Unifying theory of hypoxia tolerance: molecular/metabolic defense and rescue mechanisms for surviving oxygen lack.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Genomic imprinting of Mash2, a mouse gene required for trophoblast development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Automated method for isolation of human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

Functional impact of attachment and purification in the short term culture of human pancreatic islets

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

21 June 2018

International trial of the Edmonton protocol for islet transplantation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Culture medium modulates proinflammatory conditions of human pancreatic islets before transplantation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Visualization of early engraftment in clinical islet transplantation by positron-emission tomography.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Tissue factor and CCL2/monocyte chemoattractant protein-1 released by human islets affect islet engraftment in type 1 diabetic recipients

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Lineage tracing evidence for in vitro dedifferentiation but rare proliferation of mouse pancreatic beta-cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Serine-protease inhibition during islet isolation increases islet yield from human pancreases with prolonged ischemia

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Inhibition of p38 pathway suppresses human islet production of pro-inflammatory cytokines and improves islet graft function.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Increased number of islet-associated macrophages in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Hepatic IL-8 release during graft procurement is associated with impaired graft function after human liver transplantation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Improvements in lung compliance after pulmonary transplantation: correlation with interleukin 8 expression.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Urinary actin, interleukin-6, and interleukin-8 may predict sustained arf after ischemic injury in renal allografts

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Human pancreatic islets produce and secrete MCP-1/CCL2: relevance in human islet transplantation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

HES-1 is involved in adaptation of adult human beta-cells to proliferation in vitro

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

BMP4 regulates pancreatic progenitor cell expansion through Id2.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Insulin regulation in AhR-null mice: embryonic cardiac enlargement, neonatal macrosomia, and altered insulin regulation and response in pregnant and aging AhR-null females

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Conditional ablation of Notch signaling in pancreatic development

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0030415

21 January 2018

Improved intraportal islet transplantation outcome by systemic IKK-beta inhibition: NF-κB activity in pancreatic islets depends on oxygen availability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

25 November 2018

Angiogenic capacity of endothelial cells in islets of Langerhans

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3267725

25 November 2018

Activation and expression of ERK, JNK, and p38 MAP-kinases in isolated islets of Langerhans: implications for cultured islet survival

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell loss in isolated human islets occurs by apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel CXCL8 protein-based antagonist in acute experimental renal allograft damage

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of chemokines, CXC chemokine ligand 10 (CXCL10) and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interleukin-8 release during early reperfusion predicts graft function in human lung transplantation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: a role for p50

1 reference

https://pubmed.ncbi.nlm.nih.gov/22299040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0030415

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

2012PLoSO...730415N

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

23 September 2017

ResearchGate publication ID

0 references

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