Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors (Q31116328)

29 June 2017

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title

Treatment of cognitive deficits associated with schizophrenia: potential role of catechol-O-methyltransferase inhibitors (English)

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29 June 2017

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2

Daniel R Weinberger

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29 June 2017

José A Apud

1

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29 June 2017

publication date

1 January 2007

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29 June 2017

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29 June 2017

volume

21

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29 June 2017

issue

7

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29 June 2017

page(s)

535-557

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Unnatural practices, unspeakable actions: a study of delayed auditory feedback in schizophrenia

29 June 2017

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12 December 2020

On the existence of a global molecular network enmeshing the whole central nervous system: physiological and pathological implications.

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12 December 2020

Effects of selective catechol-O-methyltransferase inhibitors on single-trial passive avoidance retention in male rats

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12 December 2020

Catechol-O-methyltransferase gene Val/Met functional polymorphism and risk of schizophrenia: a large-scale association study plus meta-analysis

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Effect of chronic administration of L-dopa on catechol-O-methyltransferase in rat tissues

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Inhibition of rat liver and duodenum soluble catechol-O-methyltransferase by a tight-binding inhibitor OR-462

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A highly significant association between a COMT haplotype and schizophrenia.

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Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors

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Ibotenic acid lesions of medial prefrontal cortex augment swim-stress-induced locomotion

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Word and tone working memory deficits in schizophrenia

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Attenuated frontal activation in schizophrenia may be task dependent

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Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease.

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Catechol-o-methyltransferase inhibition improves set-shifting performance and elevates stimulated dopamine release in the rat prefrontal cortex

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Blockade of the noradrenaline carrier increases extracellular dopamine concentrations in the prefrontal cortex: evidence that dopamine is taken up in vivo by noradrenergic terminals

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12 December 2020

Proton magnetic resonance spectroscopy in schizophrenia

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12 December 2020

Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder

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12 December 2020

Catechol O -methyltransferase val 158 -met genotype and individual variation in the brain response to amphetamine

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12 December 2020

Catechol-O-methyltransferase and Parkinson's disease

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12 December 2020

Relation of prefrontal cortex dysfunction to working memory and symptoms in schizophrenia

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12 December 2020

Lack of association of catechol-O-methyltransferase gene Val108/158Met polymorphism with schizophrenia: a family-based association study in a Chinese population

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12 December 2020

Catechol-O-methyl transferase: pharmacological aspects and physiological role

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12 December 2020

Ro 40-7592, a novel, very potent, and orally active inhibitor of catechol-O-methyltransferase: a pharmacological study in rats

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12 December 2020

Computed electroencephalographic activity mapping in schizophrenia. The resting state reconsidered

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12 December 2020

Alterations in synaptic proteins and their encoding mRNAs in prefrontal cortex in schizophrenia: a possible neurochemical basis for 'hypofrontality'.

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12 December 2020

Schizophrenic subjects show aberrant fMRI activation of dorsolateral prefrontal cortex and basal ganglia during working memory performance.

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12 December 2020

Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and Parkinsonian patients in Finland

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12 December 2020

On-off effects in Parkinson's disease: a controlled investigation of ascorbic acid therapy

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12 December 2020

Are the cognitive effects of atypical antipsychotics influenced by their affinity to 5HT-2A receptors?

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12 December 2020

Dopamine uptake through the norepinephrine transporter in brain regions with low levels of the dopamine transporter: evidence from knock-out mouse lines

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12 December 2020

Synaptic and plasticity-associated proteins in anterior frontal cortex in severe mental illness

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12 December 2020

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia

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12 December 2020

Atomoxetine: a selective noradrenaline reuptake inhibitor for the treatment of attention-deficit/hyperactivity disorder

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12 December 2020

O-Methylation of catechol amines in vivo

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12 December 2020

Cognitive effects of olanzapine and clozapine treatment in chronic schizophrenia

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12 December 2020

Persistent elevations in dopamine and its metabolites in the nucleus accumbens after mild subchronic stress in rats with ibotenic acid lesions of the medial prefrontal cortex

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12 December 2020

New, selective catechol-O-methyltransferase inhibitors as therapeutic agents in Parkinson's disease

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12 December 2020

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

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12 December 2020

The effect of amphetamine on regional cerebral blood flow during cognitive activation in schizophrenia

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12 December 2020

COMT gene polymorphism is associated with declarative memory in adulthood and old age.

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12 December 2020

Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism

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12 December 2020

Effect of noxious tail pinch on the discharge rate of mesocortical and mesolimbic dopamine neurons: selective activation of the mesocortical system

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12 December 2020

Studies on the tight-binding nature of tolcapone inhibition of soluble and membrane-bound rat brain catechol-O-methyltransferase.

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12 December 2020

Frontal-striatal cognitive deficits in patients with chronic schizophrenia

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12 December 2020

The cortical dopamine system: role in memory and cognition

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12 December 2020

Prefrontal dopamine D1 receptors and working memory in schizophrenia.

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12 December 2020

Human catechol-O-methyltransferase: cloning and expression of the membrane-associated form

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12 December 2020

Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior

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12 December 2020

Catechol O-methyltransferase inhibitor tolcapone has minor influence on performance in experimental memory models in rats

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12 December 2020

Microdomains for dopamine volume neurotransmission in primate prefrontal cortex.

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12 December 2020

Mesoprefrontal cortical dopaminergic activity and prefrontal hypofunction in schizophrenia

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12 December 2020

Catechol O-methyltransferase (COMT) mRNA expression in the dorsolateral prefrontal cortex of patients with schizophrenia

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12 December 2020

Tolcapone, an inhibitor of catechol: O-methyltransferase, counteracts memory deficits caused by bilateral cholinotoxin lesions of the basal nuclei of Meynert

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12 December 2020

Catechol-O-methyltransferase (COMT) in rat brain: immunoelectron microscopic study with an antiserum against rat recombinant COMT protein

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12 December 2020

Evidence for a compromised dorsolateral prefrontal cortical parallel circuit in schizophrenia

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12 December 2020

Preferential transmission of the high activity allele of COMT in schizophrenia

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12 December 2020

Pharmacokinetics, pharmacodynamics, and tolerability of tolcapone: a review of early studies in volunteers

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12 December 2020

3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a si

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12 December 2020

Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1----q11.2

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12 December 2020

Heterologous monoamine reuptake: lack of transmitter specificity of neuron-specific carriers

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12 December 2020

The effect of catechol-O-methyl transferase inhibition by entacapone on the pharmacokinetics and metabolism of levodopa in healthy volunteers

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12 December 2020

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

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12 December 2020

Effects of tolcapone upon soluble and membrane-bound brain and liver catechol-O-methyltransferase

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12 December 2020

The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia.

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12 December 2020

Randomized, placebo-controlled study of tolcapone in patients with fluctuating Parkinson disease treated with levodopa-carbidopa. Tolcapone Fluctuator Study Group III.

1 reference

12 December 2020

Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder

1 reference

12 December 2020

Catechol-O-methyltransferase polymorphisms and schizophrenia: a transmission disequilibrium study in multiply affected families

1 reference

12 December 2020

Tolcapone: a potential new antidepressant detected in a novel animal model of depression

1 reference

12 December 2020

Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain

1 reference

12 December 2020

Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia

1 reference

12 December 2020

Effects of dextroamphetamine on cognitive performance and cortical activation.

1 reference

12 December 2020

Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat.

1 reference

12 December 2020

Catechol-O-methyltransferase genotype and dopamine regulation in the human brain.

1 reference

12 December 2020

No change of brain extracellular catecholamine levels after acute catechol-O-methyltransferase inhibition: a microdialysis study in anaesthetized rats

1 reference

12 December 2020

Lack of association of the COMT (Val158/108 Met) gene and schizophrenia: a meta-analysis of case-control studies

1 reference

12 December 2020

The Dopamine Hypothesis of Schizophrenia A Critical Analysis

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12 December 2020

Cognitive enhancing effects of modafinil in healthy volunteers

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12 December 2020

The development of cocaine-induced behavioral sensitization is affected by discrete quinolinic acid lesions of the prelimbic medial prefrontal cortex

1 reference

12 December 2020

The catecholaminergic innervation of primate prefrontal cortex

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12 December 2020

A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain

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12 December 2020

Differential EEG Patterns in Affective Disorder and Schizophrenia

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12 December 2020

Monoamine oxidase and catechol-O-methyltransferase inhibitors

1 reference

12 December 2020

Schizophrenic subjects activate dorsolateral prefrontal cortex during a working memory task, as measured by fMRI.

1 reference

12 December 2020

Immunohistochemical demonstration of catechol-O-methyltransferase in mammalian brain

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12 December 2020

Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia revisited.

1 reference

12 December 2020

Genetics of red cell COMT activity: Analysis of thermal stability and family data

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12 December 2020

Enzymatic O-methylation of epinephrine and other catechols.

1 reference

12 December 2020

Dextroamphetamine enhances "neural network-specific" physiological signals: a positron-emission tomography rCBF study.

1 reference

12 December 2020

Evidence for the absence of impulse-regulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons

1 reference

12 December 2020

Prefrontal and temporal blood flow in schizophrenia: resting and activation technetium-99m-HMPAO SPECT patterns in young neuroleptic-naive patients with acute disease

1 reference

12 December 2020

Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles.

1 reference

12 December 2020

Amphetamine psychosis: overview and a hypothesis

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12 December 2020

The physiological approach: functional architecture of working memory and disordered cognition in schizophrenia

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12 December 2020

No association between schizophrenia and polymorphisms in COMT in two large samples

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12 December 2020

Cognitive improvement during Tolcapone treatment in Parkinson's disease.

1 reference

12 December 2020

Variations in extracellular monoamines in the prefrontal cortex and medial hypothalamus after modafinil administration: a microdialysis study in rats

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12 December 2020

Antipsychotic drug doses and neuroleptic/dopamine receptors

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12 December 2020

Cognitive impairments in patients with schizophrenia displaying preserved and compromised intellect.

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12 December 2020

Dopaminergic modulation of cortical function in patients with Parkinson's disease

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12 December 2020

Synthesis of some novel potent and selective catechol O-methyltransferase inhibitors

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12 December 2020

Evoked extracellular dopamine in vivo in the medial prefrontal cortex.

1 reference

12 December 2020

New selective COMT inhibitors: useful adjuncts for Parkinson's disease?

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12 December 2020

Cortical dysfunction in schizophrenia during auditory word and tone working memory demonstrated by functional magnetic resonance imaging

1 reference

12 December 2020

Catechol O-methyltransferase pharmacogenetics: photoaffinity labelling and western blot analysis of human liver samples

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12 December 2020

Abnormal fMRI response of the dorsolateral prefrontal cortex in cognitively intact siblings of patients with schizophrenia

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12 December 2020

Pieces of the schizophrenia puzzle fall into place

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12 December 2020

Pharmacology of mesocortical dopamine neurons

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12 December 2020

The distribution of tyrosine hydroxylase-immunoreactive fibers in primate neocortex is widespread but regionally specific.

1 reference

12 December 2020

Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond

1 reference

12 December 2020

The human catechol-O-methyltransferase (COMT) gene maps to band q11.2 of chromosome 22 and shows a frequent RFLP with BglI

1 reference

12 December 2020

Integrated pharmacokinetics and pharmacodynamics of the novel catechol-O-methyltransferase inhibitor tolcapone during first administration to humans

1 reference

12 December 2020

Network interactions in schizophrenia - therapeutic implications

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12 December 2020

First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice

1 reference

12 December 2020

Capacity limitations in short-term memory in schizophrenia: tests of competing hypotheses

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12 December 2020

Implications for atypical antipsychotics in the treatment of schizophrenia: neurocognition effects and a neuroprotective hypothesis

1 reference

12 December 2020

Biochemical characteristics of D1 dopamine receptors: relationship to behavior and schizophrenia

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12 December 2020

Genes, dopamine and cortical signal-to-noise ratio in schizophrenia

1 reference

12 December 2020

Selective activation of mesocortical DA system by stress

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12 December 2020

Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the rat.

1 reference

12 December 2020

Distinct pharmacological regulation of evoked dopamine efflux in the amygdala and striatum of the rat in vivo.

1 reference

12 December 2020

Catechol-O-methyltransferase val108/158met genotype predicts working memory response to antipsychotic medications

1 reference

12 December 2020

Brain imaging of schizophrenia--the dopamine hypothesis

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12 December 2020

COMT genetic variation confers risk for psychotic and affective disorders: a case control study

1 reference

12 December 2020

Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme

1 reference

12 December 2020

Potentiation of the l-Dopa effect in man by the use of catechol-O-methyltransferase inhibitors

1 reference

12 December 2020

Pharmacokinetics and pharmacodynamics of entacapone and tolcapone after acute and repeated administration: a comparative study in the rat

1 reference

12 December 2020

Clinical pharmacology, therapeutic use and potential of COMT inhibitors in Parkinson's disease

1 reference

12 December 2020

Catecholamine release and uptake in the mouse prefrontal cortex

1 reference

12 December 2020

The role of D1-dopamine receptor in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed-response task

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12 December 2020

Increased dopamine transmission in schizophrenia: relationship to illness phases

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12 December 2020

Catechol-O-methyltransferase activity: a determinant of levodopa response.

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12 December 2020

EFFECT OF CHLORPROMAZINE OR HALOPERIDOL ON FORMATION OF 3METHOXYTYRAMINE AND NORMETANEPHRINE IN MOUSE BRAIN.

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12 December 2020

Tolcapone improves cognition and cortical information processing in normal human subjects

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12 December 2020

Differential effect of cocaine on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens: comparison to amphetamine

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12 December 2020

The effects of combined prefrontal cortical and hippocampal damage on dopamine-related behaviors in rats.

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12 December 2020

Variations in catechol-O-methyltransferase activity in inbred strains of rats

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12 December 2020

Interaction of COMT (Val(108/158)Met) genotype and olanzapine treatment on prefrontal cortical function in patients with schizophrenia.

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12 December 2020

The role of the regulatory enzymes of catecholamine synthesis in Parkinson's disease

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12 December 2020

Effects of antipsychotic drugs on extracellular dopamine levels in rat medial prefrontal cortex and nucleus accumbens

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12 December 2020

Low frontal electroencephalographic coherence in neuroleptic-free schizophrenic patients

1 reference

12 December 2020

The functional architecture of the prefrontal cortex and schizophrenia

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12 December 2020

Functional magnetic resonance imaging brain mapping in psychiatry: methodological issues illustrated in a study of working memory in schizophrenia.

1 reference

12 December 2020

Social disability and outcome in schizophrenic patients

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12 December 2020

Ro 40-7592: inhibition of COMT in rat brain and extracerebral tissues

1 reference

12 December 2020

Regionally specific disturbance of dorsolateral prefrontal-hippocampal functional connectivity in schizophrenia

1 reference

12 December 2020

Cloning and Characterization of Human Placental Catechol--Methyltransferase cDNA

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12 December 2020

Human liver catechol-O-methyltransferase pharmacogenetics

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12 December 2020

Executive subprocesses in working memory: relationship to catechol-O-methyltransferase Val158Met genotype and schizophrenia

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12 December 2020

Cognitive predictors of psychosocial functioning outcome in schizophrenia: a follow-up study of subjects participating in a rehabilitation program.

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12 December 2020

Receptor activity and turnover of dopamine and noradrenaline after neuroleptics

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12 December 2020

Metabolism and excretion of tolcapone, a novel inhibitor of catechol-O-methyltransferase

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12 December 2020

Dopamine transporter immunoreactivity in monkey cerebral cortex: regional, laminar, and ultrastructural localization

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12 December 2020

Molecular cloning and characterization of rat liver catechol-O-methyltransferase

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12 December 2020

Linkage disequilibrium on the COMT gene in French schizophrenics and controls

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12 December 2020

Prefrontal cognitive deficits in patients with schizophrenia treated with atypical or conventional antipsychotics

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12 December 2020

Effect of a novel catechol-O-methyltransferase inhibitor, nitecapone, on the metabolism of L-dopa in healthy volunteers

1 reference

12 December 2020

Behavioural and biochemical effects of dopamine and noradrenaline depletion within the medial prefrontal cortex of the rat

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12 December 2020

Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11

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12 December 2020

Aripiprazole increases dopamine but not noradrenaline and serotonin levels in the mouse prefrontal cortex

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12 December 2020

The principal features and mechanisms of dopamine modulation in the prefrontal cortex

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12 December 2020

Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: longitudinal evidence of a gene X environment interaction

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12 December 2020

Neonatal lesions of the medial temporal lobe disrupt prefrontal cortical regulation of striatal dopamine

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12 December 2020

Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort

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12 December 2020

Brain catecholamine metabolism in catechol-O-methyltransferase (COMT)-deficient mice

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12 December 2020

The reduced neuropil hypothesis: a circuit based model of schizophrenia

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12 December 2020

An in vivo study of dopamine release and metabolism in rat brain regions using intracerebral dialysis

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12 December 2020

Sexual dimorphism of the catechol-O-methyltransferase gene in narcolepsy is associated with response to modafinil

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12 December 2020

A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition

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12 December 2020

Interaction between diffusion and Michaelis-Menten uptake of dopamine after iontophoresis in striatum.

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12 December 2020

10.2165/00023210-200721070-00002

Identifiers

DOI

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Dimensions Publication ID

29 June 2017

1024988323

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