Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity (Q31135653)

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English	Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 June 2017

Inhibition of human leukemia in an animal model with human antibodies directed against vascular endothelial growth factor receptor 2. Correlation between antibody affinity and biological activity (English)

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29 June 2017

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author name string

Zhu Z

1

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29 June 2017

Hattori K

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29 June 2017

Zhang H

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29 June 2017

Jimenez X

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29 June 2017

Ludwig DL

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29 June 2017

Dias S

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29 June 2017

Kussie P

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29 June 2017

Koo H

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Kim HJ

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Lu D

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Liu M

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Tejada R

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Friedrich M

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Bohlen P

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Witte L

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29 June 2017

Rafii S

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publication date

1 March 2003

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604-611

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Molecular and biological properties of vascular endothelial growth factor

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402831

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Vascular endothelial growth factor and its receptors

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Vascular endothelial growth factor (VEGF) and its receptors

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Inhibition of vascular endothelial growth factor in the treatment of solid tumors

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Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics

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General aspects of anti-angiogenesis and cancer therapy

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Bone marrow angiogenesis and progression in multiple myeloma.

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Angiogenesis in myelodysplastic syndromes

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Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

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Vascular endothelial growth factor (VEGF) is an autocrine growth factor for VEGF receptor-positive human tumors.

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Vascular endothelial cell growth factor is an autocrine promoter of abnormal localized immature myeloid precursors and leukemia progenitor formation in myelodysplastic syndromes.

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Expression of vascular endothelial growth factor and its receptors in multiple myeloma and other hematopoietic malignancies

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Vascular endothelial growth factor signaling pathway as an emerging target in hematologic malignancies

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Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

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Stable remission after administration of the receptor tyrosine kinase inhibitor SU5416 in a patient with refractory acute myeloid leukemia

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The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts

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Clinical trials of antibody therapy

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Inhibition of vascular endothelial growth factor induced mitogenesis of human endothelial cells by a chimeric anti-kinase insert domain-containing receptor antibody

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Selection of high affinity human neutralizing antibodies to VEGFR2 from a large antibody phage display library for antiangiogenesis therapy

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Identification of the residues in the extracellular region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR antibodies

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A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies

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Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment

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Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

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Monoclonal antibodies targeting the VEGF receptor-2 (Flk1/KDR) as an anti-angiogenic therapeutic strategy

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Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

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Anti-tumor and anti-metastatic effects of human-vascular-endothelial-growth-factor-neutralizing antibody on human colon and gastric carcinoma xenotransplanted orthotopically into nude mice

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VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402831

7 January 2021

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KDR receptor: a key marker defining hematopoietic stem cells

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https://api.crossref.org/works/10.1038%2FSJ.LEU.2402831

7 January 2021

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Roles of two VEGF receptors, Flt-1 and KDR, in the signal transduction of VEGF effects in human vascular endothelial cells

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Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype

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Expression of vascular endothelial growth factor and its receptors flt and KDR in ovarian carcinoma.

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Concomitant over-expression of vascular endothelial growth factor and its receptors in pancreatic cancer

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Human melanoma cells secrete and respond to placenta growth factor and vascular endothelial growth factor.

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Of mice and men: hybridoma and recombinant antibodies

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Natural and designer binding sites made by phage display technology

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7 January 2021

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10.1038/SJ.LEU.2402831

1 reference

Europe PubMed Central

PubMed publication ID

29 June 2017

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PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 June 2017

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