The role of dimer asymmetry and protomer dynamics in enzyme catalysis. (Q31155485)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28104837%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

The role of dimer asymmetry and protomer dynamics in enzyme catalysis (English)

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9 April 2020

3

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9 April 2020

Adnan Sljoka

4

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9 April 2020

Emil F. Pai

10

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9 April 2020

author name string

Tae Hun Kim

1

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9 April 2020

Pedram Mehrabi

2

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9 April 2020

Christopher Ing

5

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9 April 2020

Alexandr Bezginov

6

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9 April 2020

Libin Ye

7

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9 April 2020

Régis Pomès

8

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R Scott Prosser

9

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9 April 2020

language of work or name

English

0 references

publication date

1 January 2017

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9 April 2020

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9 April 2020

volume

355

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9 April 2020

issue

6322

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The role of dynamic conformational ensembles in biomolecular recognition

9 April 2020

cites work

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Application of a Theory of Enzyme Specificity to Protein Synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Energetic dissection of Gleevec's selectivity toward human tyrosine kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Intrinsic motions along an enzymatic reaction trajectory

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The dynamic energy landscape of dihydrofolate reductase catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Hidden alternative structures of proline isomerase essential for catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

A dynamically coupled allosteric network underlies binding cooperativity in Src kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

A backbone-based theory of protein folding

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Mapping the Reaction Coordinates of Enzymatic Defluorination

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The Carbon-Fluorine Bond in Compounds of Biological Interest

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Structure of a low-population intermediate state in the release of an enzyme product

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Allostery and cooperativity revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The ensemble nature of allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Dynamic activation of an allosteric regulatory protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Protein activity regulation by conformational entropy

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The dark energy of proteins comes to light: conformational entropy and its role in protein function revealed by NMR relaxation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

An excess of catalytically required motions inhibits the scavenger decapping enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The Moderately Efficient Enzyme: Futile Encounters and Enzyme Floppiness.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Solution structure of a minor and transiently formed state of a T4 lysozyme mutant

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Microscopic insights into the NMR relaxation-based protein conformational entropy meter

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

NMR Methods to Study Dynamic Allostery

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Structural Insights into the Dynamic Process of β2-Adrenergic Receptor Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

ON THE NATURE OF ALLOSTERIC TRANSITIONS: A PLAUSIBLE MODEL

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The Catalytic and Regulatory Properties of Enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Dissociation of enzyme oligomers: a mechanism for allosteric regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Structural symmetry and protein function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Direct demonstration of half-of-the-sites reactivity in the dimeric cytochrome bc1 complex: enzyme with one inactive monomer is fully active but unable to activate the second ubiquinol oxidation site in response to ligand binding at the ubiquinone r

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The structural basis of negative cooperativity: receptors and enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Direct structural observation of an acyl-enzyme intermediate in the hydrolysis of an ester substrate by elastase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Resolution of structural heterogeneity in dynamic crystallography

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

SPARTA+: a modest improvement in empirical NMR chemical shift prediction by means of an artificial neural network

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Stopped-flow NMR spectroscopy: real-time unfolding studies of 6-19F-tryptophan-labeled Escherichia coli dihydrofolate reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Current applications of 19F NMR to studies of protein structure and dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Dynamically driven protein allostery.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The catalytic mechanism of fluoroacetate dehalogenase: a computational exploration of biological dehalogenation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Protein flexibility predictions using graph theory

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Algorithms for three-dimensional rigidity analysis and a first-order percolation transition.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Allosteric proteins and cellular control systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Intrinsic dynamics of an enzyme underlies catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Enzyme millisecond conformational dynamics do not catalyze the chemical step

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Catalysis by dihydrofolate reductase and other enzymes arises from electrostatic preorganization, not conformational motions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Studying the role of protein dynamics in an SN2 enzyme reaction using free-energy surfaces and solvent coordinates

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Perspective: Defining and quantifying the role of dynamics in enzyme catalysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Protein solvation in allosteric regulation: a water effect on hemoglobin

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Conformational selection and functional dynamics of calmodulin: a (19)F nuclear magnetic resonance study

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Is allostery an intrinsic property of all dynamic proteins?

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Sequence- and activity-based screening of microbial genomes for novel dehalogenases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Phasercrystallographic software

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Features and development of Coot

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

REFMAC5 dictionary: organization of prior chemical knowledge and guidelines for its use

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Overview of the CCP4 suite and current developments

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

PHENIX: a comprehensive Python-based system for macromolecular structure solution

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Reaction trajectory revealed by a joint analysis of protein data bank

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Tracing an allosteric pathway regulating the activity of the HslV protease

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

NMR View: A computer program for the visualization and analysis of NMR data

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

The CCPN data model for NMR spectroscopy: development of a software pipeline

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Improved side-chain torsion potentials for the Amber ff99SB protein force field

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Comparison of simple potential functions for simulating liquid water

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

ACPYPE - AnteChamber PYthon Parser interfacE

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Automatic atom type and bond type perception in molecular mechanical calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Canonical dynamics: Equilibrium phase-space distributions

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Particle mesh Ewald: An N⋅log(N) method for Ewald sums in large systems

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

P-LINCS: A Parallel Linear Constraint Solver for Molecular Simulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

MDTraj: A Modern Open Library for the Analysis of Molecular Dynamics Trajectories.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

VMD: visual molecular dynamics

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Modeller: generation and refinement of homology-based protein structure models

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Nature of Forces between Large Molecules of Biological Interest*

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

Activation of the A2A adenosine G-protein-coupled receptor by conformational selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSCIENCE.AAG2355

21 January 2018

Identifiers

DOI

10.1126/SCIENCE.AAG2355

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28104837%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference