A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation (Q32884462)

11 July 2017

title

A Src family kinase-Shp2 axis controls RUNX1 activity in megakaryocyte and T-lymphocyte differentiation (English)

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Protein tyrosine phosphatase non-receptor type 11

11 July 2017

main subject

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protein tyrosine phosphatase activity

GOA release 2020-03-11

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GOA release 2020-03-11

Rous sarcoma oncogene

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GOA release 2020-03-11

author name string

Hui Huang

1

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11 July 2017

Andrew J Woo

2

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11 July 2017

Zachary Waldon

3

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11 July 2017

Yocheved Schindler

4

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11 July 2017

Tyler B Moran

5

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11 July 2017

Helen H Zhu

6

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11 July 2017

Gen-Sheng Feng

7

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11 July 2017

Hanno Steen

8

1 reference

11 July 2017

Alan B Cantor

9

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11 July 2017

language of work or name

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3 July 2012

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11 July 2017

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11 July 2017

volume

26

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11 July 2017

issue

14

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11 July 2017

page(s)

1587-1601

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describes a project that uses

11 July 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3404386/fullTextXML

inferred from PubMed Central ID database lookup

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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14 July 2018

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Conditional deletion of Shp2 tyrosine phosphatase in thymocytes suppresses both pre-TCR and TCR signals.

31 October 2018

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Increased megakaryocytopoiesis in Lyn-deficient mice

31 October 2018

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Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations.

31 October 2018

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Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing.

31 October 2018

1 reference

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Novel loss-of-function mutations of the haematopoiesis-related transcription factor, acute myeloid leukaemia 1/runt-related transcription factor 1, detected in acute myeloblastic leukaemia and myelodysplastic syndrome

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404386

Identification and activation of Src family kinases in primary megakaryocytes

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404386

Proviral insertion indicates a dominant oncogenic role for Runx1/AML-1 in T-cell lymphoma.

31 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3404386

Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development.

31 October 2018

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The AML1 transcription factor functions to develop and maintain hematogenic precursor cells in the embryonic aorta-gonad-mesonephros region.

31 October 2018

1 reference

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Overexpression of AML1 transcription factor drives thymocytes into the CD8 single-positive lineage

31 October 2018

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12 December 2020

Immature Megakaryocytes in the Mouse: Morphology and quantitation by acetylcholinesterase staining

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12 December 2020

Haploinsufficiency of AML1 results in a decrease in the number of LTR-HSCs while simultaneously inducing an increase in more mature progenitors

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12 December 2020

Activation of SHP2 protein-tyrosine phosphatase increases HoxA10-induced repression of the genes encoding gp91(PHOX) and p67(PHOX)

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12 December 2020

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo

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12 December 2020

Five new pedigrees with inherited RUNX1 mutations causing familial platelet disorder with propensity to myeloid malignancy

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12 December 2020

Diminution of the AML1 transcription factor function causes differential effects on the fates of CD4 and CD8 single-positive T cells

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12 December 2020

Haploinsufficiency of AML1 affects the temporal and spatial generation of hematopoietic stem cells in the mouse embryo

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12 December 2020

Identifiers

DOI

10.1101/GAD.192054.112

1 reference

11 July 2017

1 reference

11 July 2017

1 reference