Cancer cell-based genomic and small molecule screens (Q33266186)

24 July 2017

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title

Cancer cell-based genomic and small molecule screens (English)

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24 July 2017

Jeremy S Caldwell

1

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24 July 2017

publication date

1 January 2007

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Advances in Cancer Research

24 July 2017

published in

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24 July 2017

volume

96

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24 July 2017

page(s)

145-173

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Isolation and expression of functional high-affinity Fc receptor complementary DNAs

24 July 2017

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The end of the beginning for genomic medicine

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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Role for a bidentate ribonuclease in the initiation step of RNA interference

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Oncogenic kinase signalling

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7 January 2021

Eph receptor tyrosine kinases in tumor and tumor microenvironment

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7 January 2021

Induction of an interferon response by RNAi vectors in mammalian cells

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7 January 2021

Knowledge-based analysis of microarray gene expression data by using support vector machines

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7 January 2021

A system for stable expression of short interfering RNAs in mammalian cells

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7 January 2021

Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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7 January 2021

Phase I clinical trial of 7-cyanoquinocarcinol (DX-52-1) in adult patients with refractory solid malignancies

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7 January 2021

Systems biology in drug discovery

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Genome-scale functional profiling of the mammalian AP-1 signaling pathway

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7 January 2021

Site of action of two novel pyrimidine biosynthesis inhibitors accurately predicted by the compare program

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7 January 2021

Complex phenotypic assays in high-throughput screening

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7 January 2021

Application of high-throughput screening techniques to drug discovery.

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7 January 2021

Identification of candidate predictive markers of anticancer drug sensitivity using a panel of human cancer cell lines

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7 January 2021

Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins

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7 January 2021

A concise and traceless linker strategy toward combinatorial libraries of 2,6,9-substituted purines

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7 January 2021

Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells

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7 January 2021

Phase I clinical and pharmacokinetic investigation of didemnin B, a cyclic depsipeptide

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7 January 2021

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

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7 January 2021

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor

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7 January 2021

Flow cytometry for high-throughput, high-content screening

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7 January 2021

Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets

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7 January 2021

Web-based tools for mining the NCI databases for anticancer drug discovery.

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7 January 2021

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth.

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7 January 2021

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

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7 January 2021

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)

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7 January 2021

Missing pieces in the NF-kappaB puzzle

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7 January 2021

The Concept of the Penicillin Target from 1965 until Today: The Thirteenth Marjory Stephenson Memorial Lecture

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7 January 2021

p53: twenty five years understanding the mechanism of genome protection

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7 January 2021

Mapping chemical space using molecular descriptors and chemical genetics: deacetylase inhibitors

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Cyclophilin: a specific cytosolic binding protein for cyclosporin A

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells

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7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

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7 January 2021

A library of siRNA duplexes targeting the phosphoinositide 3-kinase pathway: determinants of gene silencing for use in cell-based screens

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7 January 2021

Identification of p53 regulators by genome-wide functional analysis

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7 January 2021

Design of a genome-wide siRNA library using an artificial neural network

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7 January 2021

Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

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7 January 2021

Cytotoxicity of a new IMP dehydrogenase inhibitor, benzamide riboside, to human myelogenous leukemia K562 cells

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7 January 2021

Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space

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7 January 2021

Comparison of SOM point densities based on different criteria.

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7 January 2021

Inhibition of NF-kappa B by sodium salicylate and aspirin

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7 January 2021

Mechanisms and functions of Eph and ephrin signalling

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7 January 2021

Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen

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7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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7 January 2021

Identification of the Wnt signaling activator leucine-rich repeat in Flightless interaction protein 2 by a genome-wide functional analysis

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7 January 2021

Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

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7 January 2021

Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways

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7 January 2021

An efficient rapid system for profiling the cellular activities of molecular libraries.

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7 January 2021

Visualization of data

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7 January 2021

Arrayed adenoviral expression libraries for functional screening

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7 January 2021

Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector

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7 January 2021

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Ras protein signalling

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7 January 2021

A resource for large-scale RNA-interference-based screens in mammals.

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7 January 2021

Nonspecific, concentration-dependent stimulation and repression of mammalian gene expression by small interfering RNAs (siRNAs).

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Method for analyzing signaling networks in complex cellular systems

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7 January 2021

PASS biological activity spectrum predictions in the enhanced open NCI database browser

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7 January 2021

Mining the National Cancer Institute's tumor-screening database: identification of compounds with similar cellular activities

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Biological Mechanism Profiling Using an Annotated Compound Library

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7 January 2021

A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

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7 January 2021

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

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7 January 2021

Why drugs fail--a study on side effects in new chemical entities.

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7 January 2021

Mechanisms of action of flavopiridol

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7 January 2021

Iridals are a novel class of ligands for phorbol ester receptors with modest selectivity for the RasGRP receptor subfamily

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7 January 2021

Mining the NCI anticancer drug discovery databases: genetic function approximation for the QSAR study of anticancer ellipticine analogues.

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7 January 2021

Mining the National Cancer Institute Anticancer Drug Discovery Database: cluster analysis of ellipticine analogs with p53-inverse and central nervous system-selective patterns of activity.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Mining and visualizing large anticancer drug discovery databases

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Activation of the interferon system by short-interfering RNAs

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

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7 January 2021

Lentivirus-delivered stable gene silencing by RNAi in primary cells

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

A gene atlas of the mouse and human protein-encoding transcriptomes

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7 January 2021

High-throughput and ultra-high-throughput screening: solution- and cell-based approaches

1 reference

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7 January 2021

Detection of bcr-abl fusion in chronic myelogeneous leukemia by in situ hybridization

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7 January 2021

Use of isogenic human cancer cells for high-throughput screening and drug discovery

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7 January 2021

Neural computing in cancer drug development: predicting mechanism of action

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7 January 2021

An information-intensive approach to the molecular pharmacology of cancer.

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7 January 2021

Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

COMPARE: a web accessible tool for investigating mechanisms of cell growth inhibition.

1 reference

https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

An approach to genomewide screens of expressed small interfering RNAs in mammalian cells.

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Role of AMP-activated protein kinase in mechanism of metformin action

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https://api.crossref.org/works/10.1016%2FS0065-230X%2806%2996006-0

7 January 2021

Combinatorial chemistry as a tool for drug discovery

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7 January 2021

10.1016/S0065-230X(06)96006-0

Identifiers

DOI

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release_drfhyxvfvjbahlbmsx26oye7nm

24 July 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/drfhyxvfvjbahlbmsx26oye7nm

24 November 2022

mapped directly with Wikidata item

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