Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance (Q33338248)

25 July 2017

title

Overexpression of Pax6 results in microphthalmia, retinal dysplasia and defective retinal ganglion cell axon guidance (English)

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25 July 2017

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retinal ganglion cell

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1

Martine Manuel

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25 July 2017

Thomas Pratt

2

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David J Price

object named as

David J Price

series ordinal

5

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author name string

Min Liu

series ordinal

3

1 reference

25 July 2017

Glen Jeffery

series ordinal

4

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25 July 2017

publication date

28 May 2008

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BMC Developmental Biology

25 July 2017

published in

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25 July 2017

volume

8

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25 July 2017

page(s)

59

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Creative Commons Attribution 2.0 Generic

25 July 2017

copyright license

start time

28 May 2008

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Slit proteins regulate distinct aspects of retinal ganglion cell axon guidance within dorsal and ventral retina

21 June 2018

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Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type

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Magnitude of binocular vision controlled by islet-2 repression of a genetic program that specifies laterality of retinal axon pathfinding

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Foxd1 is required for proper formation of the optic chiasm

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The winged helix transcription factor Foxg1 facilitates retinal ganglion cell axon crossing of the ventral midline in the mouse

21 June 2018

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R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons

21 June 2018

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Zic2 patterns binocular vision by specifying the uncrossed retinal projection

21 June 2018

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Ephrin-B2 and EphB1 mediate retinal axon divergence at the optic chiasm

21 June 2018

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Gap junctions mediate bystander cell death in developing retina

21 June 2018

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Regulation of proliferation, cell fate specification and differentiation by the homeodomain proteins Prox1, Six3, and Chx10 in the developing retina.

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Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development

21 June 2018

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Retinal pigmented epithelium determination requires the redundant activities of Pax2 and Pax6

21 June 2018

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A dorso-ventral gradient of Pax6 in the developing retina suggests a role in topographic map formation

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

The L1 cell adhesion molecule is essential for topographic mapping of retinal axons

21 June 2018

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Molecular mechanisms of axon guidance

21 June 2018

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Pax6; a pleiotropic player in development.

21 June 2018

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Development of normal retinal organization depends on Sonic hedgehog signaling from ganglion cells

21 June 2018

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Mutually regulated expression of Pax6 and Six3 and its implications for the Pax6 haploinsufficient lens phenotype

21 June 2018

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Six3-mediated auto repression and eye development requires its interaction with members of the Groucho-related family of co-repressors

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Slit1 and Slit2 cooperate to prevent premature midline crossing of retinal axons in the mouse visual system

21 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Primary defects in the lens underlie complex anterior segment abnormalities of the Pax6 heterozygous eye.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos

21 June 2018

1 reference

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Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Pax6 is required for the multipotent state of retinal progenitor cells

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Retinal changes in magnesium-deficient rats

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Overexpression of PAX6(5a) in lens fiber cells results in cataract and upregulation of (alpha)5(beta)1 integrin expression

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Kinase independent function of EphB receptors in retinal axon pathfinding to the optic disc from dorsal but not ventral retina.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1- and DCC-deficient mice

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Pax2 expression and retinal morphogenesis in the normal and Krd mouse

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Neural cell adhesion molecules of the immunoglobulin superfamily: role in axon growth and guidance

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Netrin-1 and DCC mediate axon guidance locally at the optic disc: loss of function leads to optic nerve hypoplasia

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Influence of PAX6 gene dosage on development: overexpression causes severe eye abnormalities

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Multiple functions for Pax6 in mouse eye and nasal development.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Developmental control of N-CAM expression by Hox and Pax gene products

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

The role of Pax-6 in eye and nasal development

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

The Brn-3 family of POU-domain factors: primary structure, binding specificity, and expression in subsets of retinal ganglion cells and somatosensory neurons

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Double labeling with iodo- and bromodeoxyuridine for cell kinetics studies

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Pax-6, a murine paired box gene, is expressed in the developing CNS

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Mouse small eye results from mutations in a paired-like homeobox-containing gene

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Heparan sulphation patterns generated by specific heparan sulfotransferase enzymes direct distinct aspects of retinal axon guidance at the optic chiasm.

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Brn3a-expressing retinal ganglion cells project specifically to thalamocortical and collicular visual pathways.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

A bHLH transcriptional network regulating the specification of retinal ganglion cells

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Functional equivalence of Brn3 POU-domain transcription factors in mouse retinal neurogenesis

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Ectopic Pax6 expression disturbs lens fiber cell differentiation.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Genetic analysis of the homeodomain transcription factor Chx10 in the retina using a novel multifunctional BAC transgenic mouse reporter

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Direct and concentration-dependent regulation of the proneural gene Neurogenin2 by Pax6.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Apoptotic death of beta cells after optic nerve transection in adult cats.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Corneal Abnormalities inPax6+/−Small Eye Mice Mimic Human Aniridia-Related Keratopathy

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Requirement for Pax6 in corneal morphogenesis: a role in adhesion

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Pax6 is required for establishing naso-temporal and dorsal characteristics of the optic vesicle.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Neuroprotective effects of lamotrigine and remacemide on excitotoxicity induced by glutamate agonists in isolated chick retina

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Target-derived neurotrophic factors regulate the death of developing forebrain neurons after a change in their trophic requirements.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Abnormal polarization and axon outgrowth in retinal ganglion cells lacking the POU-domain transcription factor Brn-3b.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Different roles for Pax6 in the optic vesicle and facial epithelium mediate early morphogenesis of the murine eye.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Apoptotic cell death of proliferating neuroepithelial cells in the embryonic retina is prevented by insulin.

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

An immunohistochemical study of an autosomal dominant feline rod/cone dysplasia (Rdy cats).

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2422841

Inherited retinal degeneration and apoptosis in mutant zebrafish

31 October 2018

1 reference

12 December 2020

Truncated forms of Pax-6 disrupt lens morphology in transgenic mice

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12 December 2020

Differential expression of cadherin adhesion receptors in neural retina of the postnatal mouse

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12 December 2020

Neural induction and patterning by fibroblast growth factor, notochord and somite tissue in Xenopus

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12 December 2020

Experimental induction of retinal ganglion cell death in adult mice

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12 December 2020

c-Fos protein in photoreceptor cell death after photic injury in rats

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12 December 2020

Lactate prevents the alterations in tissue amino acids, decline in ATP, and cell damage due to aglycemia in retina

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12 December 2020

Dosage requirement and allelic expression of PAX6 during lens placode formation

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12 December 2020

Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord

1 reference

12 December 2020

Pax6 heterozygous eyes show defects in chamber angle differentiation that are associated with a wide spectrum of other anterior eye segment abnormalities

1 reference

12 December 2020

Origins of crossed and uncrossed retinal projections in pigmented and albino mice

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12 December 2020

Small eyes (Sey): a homozygous lethal mutation on chromosome 2 which affects the differentiation of both lens and nasal placodes in the mouse

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12 December 2020

Role of N-cadherin cell adhesion molecules in the histogenesis of neural retina

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12 December 2020

Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis

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12 December 2020

The first retinal axon growth in the mouse optic chiasm: axon patterning and the cellular environment

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12 December 2020

Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2

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12 December 2020

Identifiers

DOI

10.1186/1471-213X-8-59

1 reference

25 July 2017

1 reference

25 July 2017

1 reference