Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6. (Q33419081)

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23 January 2020

title

Inhibition of GSK3 phosphorylation of beta-catenin via phosphorylated PPPSPXS motifs of Wnt coreceptor LRP6 (English)

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23 January 2020

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2

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23 January 2020

author name string

Geng Wu

series ordinal

1

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23 January 2020

Jose Garcia Abreu

series ordinal

3

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23 January 2020

Xi He

series ordinal

4

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language of work or name

English

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publication date

18 March 2009

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23 January 2020

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23 January 2020

volume

4

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23 January 2020

issue

3

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23 January 2020

page(s)

e4926

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Creative Commons Attribution 4.0 International

23 January 2020

copyright license

start time

18 March 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6.

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Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction

21 June 2018

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Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase

21 June 2018

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21 June 2018

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You Wnt some, you lose some: oncogenes in the Wnt signaling pathway

21 June 2018

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Axin-mediated CKI phosphorylation of beta-catenin at Ser 45: a molecular switch for the Wnt pathway

21 June 2018

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Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism

21 June 2018

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Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila

21 June 2018

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Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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21 June 2018

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An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of beta-catenin

21 June 2018

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21 June 2018

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The F-box protein beta-TrCP associates with phosphorylated beta-catenin and regulates its activity in the cell.

21 June 2018

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The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin.

21 June 2018

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The SCFbeta-TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in IkappaBalpha and beta-catenin and stimulates IkappaBalpha ubiquitination in vitro

21 June 2018

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Identification of c-MYC as a target of the APC pathway

21 June 2018

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Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta-catenin and promotes GSK-3beta-dependent phosphorylation of beta-catenin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

Formation and function of Spemann's organizer

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

beta-catenin is a target for the ubiquitin-proteasome pathway

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

Nuclear localization of beta-catenin by interaction with transcription factor LEF-1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

Functional interaction of beta-catenin with the transcription factor LEF-1

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2654145

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos

21 June 2018

1 reference

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Glycogen synthase kinase-3 and dorsoventral patterning in Xenopus embryos

21 June 2018

1 reference

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Role of glycogen synthase kinase 3 beta as a negative regulator of dorsoventral axis formation in Xenopus embryos.

21 June 2018

1 reference

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Axis determination in Xenopus involves biochemical interactions of axin, glycogen synthase kinase 3 and beta-catenin.

21 June 2018

1 reference

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Threonine 41 in beta-catenin serves as a key phosphorylation relay residue in beta-catenin degradation

31 October 2018

1 reference

12 December 2020

Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts

1 reference

12 December 2020

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau

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12 December 2020

Regulation of Spemann organizer formation by the intracellular kinase Xgsk-3

1 reference

12 December 2020

Serine phosphorylation-regulated ubiquitination and degradation of beta-catenin

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0004926

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19293931%20AND%20SRC:MED&resulttype=core&format=json

23 January 2020

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1 reference

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23 January 2020

PubMed publication ID

19293931

1 reference