A phase 1/2 study of oral panobinostat combined with melphalan for patients with relapsed or refractory multiple myeloma (Q33410997)

26 July 2017

title

A phase 1/2 study of oral panobinostat combined with melphalan for patients with relapsed or refractory multiple myeloma (English)

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26 July 2017

James R Berenson

1

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26 July 2017

James D Hilger

2

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Ori Yellin

3

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Ralph V Boccia

4

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Jeffrey Matous

5

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Kenneth Dressler

6

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Hassan H Ghazal

7

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Saad Jamshed

8

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Edwin C Kingsley

9

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Wael A Harb

10

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Stephen J Noga

11

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Youram Nassir

12

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Regina A Swift

13

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Robert Vescio

14

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publication date

18 October 2013

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26 July 2017

volume

93

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issue

1

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page(s)

89-98

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The histone deacetylase inhibitor LBH589 enhances the anti-myeloma effects of chemotherapy in vitro and in vivo

26 July 2017

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Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes

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A phase I study of intravenous LBH589, a novel cinnamic hydroxamic acid analogue histone deacetylase inhibitor, in patients with refractory hematologic malignancies

21 January 2018

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NVP-LAQ824 is a potent novel histone deacetylase inhibitor with significant activity against multiple myeloma

21 January 2018

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Bortezomib alone or in combination with the histone deacetylase inhibitor JNJ-26481585: effect on myeloma bone disease in the 5T2MM murine model of myeloma.

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Vorinostat enhances the antimyeloma effects of melphalan and bortezomib

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Phase I study of vorinostat in combination with bortezomib for relapsed and refractory multiple myeloma

21 January 2018

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A phase II multiple dose clinical trial of histone deacetylase inhibitor ITF2357 in patients with relapsed or progressive multiple myeloma

21 January 2018

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The histone deacetylase inhibitor LBH589 is a potent antimyeloma agent that overcomes drug resistance.

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Development of the pan-DAC inhibitor panobinostat (LBH589): successes and challenges

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Panobinostat (LBH589): a potent pan-deacetylase inhibitor with promising activity against hematologic and solid tumors

21 January 2018

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Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma.

21 January 2018

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Phase II study of the histone deacetylase inhibitor panobinostat (LBH589) in patients with low or intermediate-1 risk myelodysplastic syndrome

21 January 2018

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Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma

21 January 2018

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Results of a phase 2 trial of the single-agent histone deacetylase inhibitor panobinostat in patients with relapsed/refractory Waldenström macroglobulinemia

21 January 2018

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Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies.

21 January 2018

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Aggresome induction by proteasome inhibitor bortezomib and alpha-tubulin hyperacetylation by tubulin deacetylase (TDAC) inhibitor LBH589 are synergistic in myeloma cells

21 January 2018

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In vitro and in vivo rationale for the triple combination of panobinostat (LBH589) and dexamethasone with either bortezomib or lenalidomide in multiple myeloma

21 January 2018

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PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00277-013-1910-2

Phase II study of melphalan, thalidomide and prednisone combined with oral panobinostat in patients with relapsed/refractory multiple myeloma

21 January 2018

1 reference

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Criteria for evaluating disease response and progression in patients with multiple myeloma treated by high-dose therapy and haemopoietic stem cell transplantation. Myeloma Subcommittee of the EBMT. European Group for Blood and Marrow Transplant

21 January 2018

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10.1007/S00277-013-1910-2

21 January 2018

Identifiers

DOI

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26 July 2017

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