A mammalianized synthetic nitroreductase gene for high-level expression (Q33497608)

27 July 2017

title

A mammalianized synthetic nitroreductase gene for high-level expression (English)

1 reference

27 July 2017

Josef Priller

5

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author name string

Maik Grohmann

1

1 reference

27 July 2017

Nils Paulmann

2

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27 July 2017

Sebastian Fleischhauer

3

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27 July 2017

Jakob Vowinckel

4

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27 July 2017

Diego J Walther

6

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27 July 2017

language of work or name

English

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publication date

27 August 2009

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27 July 2017

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27 July 2017

volume

9

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27 July 2017

issue

1

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22 June 2019

page(s)

301

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Suicide genes for cancer therapy

27 July 2017

cites work

1 reference

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Direct positive selection for improved nitroreductase variants using SOS triggering of bacteriophage lambda lytic cycle

21 June 2018

1 reference

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Tissue-specific differences in human transfer RNA expression

21 June 2018

1 reference

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Codon optimization of bacterial luciferase (lux) for expression in mammalian cells.

21 June 2018

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Timeline: Chemotherapy and the war on cancer.

21 June 2018

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Tissue-specific codon usage and the expression of human genes

21 June 2018

1 reference

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Generation of Escherichia coli nitroreductase mutants conferring improved cell sensitization to the prodrug CB1954.

21 June 2018

1 reference

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Conditional ablation of neurones in transgenic mice.

21 June 2018

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Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors

21 June 2018

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Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

21 June 2018

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Codon usage tabulated from international DNA sequence databases: status for the year 2000

21 June 2018

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Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

21 June 2018

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p53--an acrobat in tumorigenesis

21 June 2018

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The bystander effect of the nitroreductase/CB1954 enzyme/prodrug system is due to a cell-permeable metabolite

21 June 2018

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The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).

21 June 2018

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Codon usage and tRNA content in unicellular and multicellular organisms

21 June 2018

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Codon usage patterns in Escherichia coli, Bacillus subtilis, Saccharomyces cerevisiae, Schizosaccharomyces pombe, Drosophila melanogaster and Homo sapiens; a review of the considerable within-species diversity

21 June 2018

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Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: a negative selection system

21 June 2018

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Comparison of cell proliferation kinetics in human and experimental tumors: response to irradiation

21 June 2018

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7-Hydroxytryptophan, a novel, specific, cytotoxic agent for carcinoids and other serotonin-producing tumors

21 June 2018

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2,4-dinitro-5-ethyleneiminobenzamide (CB 1954): a potent and selective inhibitor of the growth of the Walker carcinoma 256.

21 January 2018

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Selective cell ablation in transgenic mice expression E. coli nitroreductase

21 January 2018

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Nitroreductase-mediated cell ablation is very rapid and mediated by a p53-independent apoptotic pathway

21 January 2018

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Selective ablation of olfactory receptor neurons without functional impairment of vomeronasal receptor neurons in OMP-ntr transgenic mice

21 January 2018

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The expression of bacterial nitroreductase in transgenic mice results in specific cell killing by the prodrug CB1954.

21 January 2018

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Inducible ablation of astrocytes shows that these cells are required for neuronal survival in the adult brain

21 January 2018

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Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer

21 January 2018

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Virus-directed, enzyme prodrug therapy with nitroimidazole reductase: a phase I and pharmacokinetic study of its prodrug, CB1954.

21 January 2018

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Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954

31 October 2018

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12 December 2020

Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system

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12 December 2020

Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy

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12 December 2020

Codon optimization, genetic insulation, and an rtTA reporter improve performance of the tetracycline switch

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12 December 2020

Identifiers

DOI

10.1186/1471-2407-9-301

1 reference

Dimensions Publication ID

27 July 2017

0 references

1 reference

27 July 2017

1 reference