Antifungals: mechanism of action and resistance, established and novel drugs (Q33538696)

27 July 2017

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title

Antifungals: mechanism of action and resistance, established and novel drugs (English)

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27 July 2017

Georgopapadakou NH

1

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27 July 2017

publication date

1 October 1998

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Current Opinion in Microbiology

27 July 2017

published in

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27 July 2017

volume

1

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27 July 2017

issue

5

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27 July 2017

page(s)

547-557

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Opportunistic mycoses in the immunocompromised host: experience at a cancer center and review

27 July 2017

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Novel aspect of amphotericin B action: accumulation in human monocytes potentiates killing of phagocytosed Candida albicans

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7 January 2021

Effects of naftifine and terbinafine, two allylamine antifungal drugs, on selected functions of human polymorphonuclear leukocytes

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Molecular mechanisms of drug resistance in fungi

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Lipid formulations for amphotericin B: does the emperor need new clothes?

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7 January 2021

Role of cell defense against oxidative damage in the resistance of Candida albicans to the killing effect of amphotericin B.

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7 January 2021

Trichosporon beigelii, an emerging pathogen resistant to amphotericin B

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7 January 2021

Overview of medically important antifungal azole derivatives

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7 January 2021

Antifungal agents: chemotherapeutic targets and immunologic strategies

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7 January 2021

Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans

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7 January 2021

Increased sensitivity of Candida albicans cells accumulating 14 alpha-methylated sterols to active oxygen: possible relevance to in vivo efficacies of azole antifungal agents

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7 January 2021

Emergence of azole drug resistance in Candida species from HIV-infected patients receiving prolonged fluconazole therapy for oral candidosis

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7 January 2021

Resistance of Candida species to fluconazole

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7 January 2021

Failure of fluconazole treatment in cryptococcal meningitis despite adequate CSF levels

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7 January 2021

Molecular genetic studies on the mode of action of azole antifungal agents

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7 January 2021

Clinical, cellular, and molecular factors that contribute to antifungal drug resistance.

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7 January 2021

Resistance of Candida albicans to azole antifungal agents

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7 January 2021

Multiple resistance mechanisms to azole antifungals in yeast clinical isolates.

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7 January 2021

Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.

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7 January 2021

Saccharomyces cerevisiae ABC proteins and their relevance to human health and disease

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7 January 2021

Multidrug-resistant transport proteins in yeast: complete inventory and phylogenetic characterization of yeast open reading frames with the major facilitator superfamily

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7 January 2021

Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals

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7 January 2021

Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene.

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7 January 2021

The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter

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7 January 2021

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters

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7 January 2021

Mechanism of action and biochemical selectivity of allylamine antimycotic agents

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7 January 2021

Squalene epoxidase as a target for the allylamines

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7 January 2021

Effects of squalene epoxidase inhibitors on Candida albicans

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7 January 2021

Evolving role of flucytosine in immunocompromised patients: new insights into safety, pharmacokinetics, and antifungal therapy

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7 January 2021

Flucytosine--what is its future?

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7 January 2021

A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase

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7 January 2021

Cell wall integrity modulates RHO1 activity via the exchange factor ROM2

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7 January 2021

Rho1p, a yeast protein at the interface between cell polarization and morphogenesis

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7 January 2021

Identification of yeast Rho1p GTPase as a regulatory subunit of 1,3-beta-glucan synthase.

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7 January 2021

A conserved kinase cascade for MAP kinase activation in yeast.

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7 January 2021

A downstream target of RHO1 small GTP-binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.

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7 January 2021

Mutants in the S. cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect

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7 January 2021

The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1,3-beta-D-glucan synthase

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7 January 2021

Differential expression and function of two homologous subunits of yeast 1,3-beta-D-glucan synthase

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7 January 2021

The fungal cell wall as a drug target

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7 January 2021

Critical steps in fungal cell wall synthesis: strategies for their inhibition.

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7 January 2021

Antibiotics that inhibit fungal cell wall development

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7 January 2021

Evaluation of water-soluble pneumocandin analogs L-733560, L-705589, and L-731373 with mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis

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7 January 2021

Echinocandins and pneumocandins--a new antifungal class with a novel mode of action

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7 January 2021

Photoaffinity analog of the semisynthetic echinocandin LY303366: identification of echinocandin targets in Candida albicans

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7 January 2021

Genetics and molecular biology of chitin synthesis in fungi

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7 January 2021

Differential inhibition of chitin synthetases 1 and 2 from Saccharomyces cerevisiae by polyoxin D and nikkomycins

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7 January 2021

Nikkomycin Z is a specific inhibitor of Saccharomyces cerevisiae chitin synthase isozyme Chs3 in vitro and in vivo

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7 January 2021

Attenuated virulence of chitin-deficient mutants of Candida albicans

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7 January 2021

In vitro and in vivo antifungal activities of BMS-181184

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7 January 2021

In vitro antifungal and fungicidal spectra of a new pradimicin derivative, BMS-181184

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7 January 2021

Studies on the mode of antifungal action of pradimicin antibiotics. II. D-mannopyranoside-binding site and calcium-binding site.

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7 January 2021

Antifungals targeted to the cell wall

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7 January 2021

Inhibitors of sterol biosynthesis and their applications

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7 January 2021

The search for new triazole antifungal agents

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7 January 2021

Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation

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7 January 2021

Translation elongation factor 3: a fungus-specific translation factor?

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7 January 2021

The Elongation Factor 3 Unique in Higher Fungi and Essential for Protein Biosynthesis Is an E Site Factor

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7 January 2021

Identification and kinetic analysis of a functional homolog of elongation factor 3, YEF3 in Saccharomyces cerevisiae

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7 January 2021

Isolation and Characterisation of an Antifungal Antibiotic (GR135402) with Protein Synthesis Inhibition.

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7 January 2021

Genetic and biochemical studies of protein N-myristoylation

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7 January 2021

Targeted gene replacement demonstrates that myristoyl-CoA: protein N-myristoyltransferase is essential for viability of Cryptococcus neoformans.

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7 January 2021

Genetic studies reveal that myristoylCoA:protein N-myristoyltransferase is an essential enzyme in Candida albicans

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7 January 2021

Crystal structure of the anti-fungal target N-myristoyl transferase

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7 January 2021

Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifung

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7 January 2021

Novel biologically active nonpeptidic inhibitors of myristoylCoA:protein N-myristoyltransferase

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7 January 2021

Is there a role for GPIs in yeast cell-wall assembly?

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7 January 2021

In silicio identification of glycosyl-phosphatidylinositol-anchored plasma-membrane and cell wall proteins of Saccharomyces cerevisiae

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7 January 2021

Fumonisins: fungal toxins that shed light on sphingolipid function

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7 January 2021

The discovery of australifungin, a novel inhibitor of sphinganine N-acyltransferase from Sporormiella australis. Producing organism, fermentation, isolation, and biological activity

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7 January 2021

Sphingolipid synthesis as a target for antifungal drugs. Complementation of the inositol phosphorylceramide synthase defect in a mutant strain of Saccharomyces cerevisiae by the AUR1 gene

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7 January 2021

The AUR1 gene in Saccharomyces cerevisiae encodes dominant resistance to the antifungal agent aureobasidin A (LY295337).

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7 January 2021

Structure of aureobasidin A

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7 January 2021

Khafrefungin, a novel inhibitor of sphingolipid synthesis

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7 January 2021

The galbonolides. Novel, powerful antifungal macrolides from Streptomyces galbus ssp. eurythermus

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7 January 2021

Rustmicin, a potent antifungal agent, inhibits sphingolipid synthesis at inositol phosphoceramide synthase

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7 January 2021

Antimitotic agents: chemistry and recognition of tubulin molecule

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7 January 2021

DNA topoisomerases from pathogenic fungi: targets for the discovery of antifungal drugs

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7 January 2021

Selective inhibition of topoisomerases from Pneumocystis carinii compared with that of topoisomerases from mammalian cells

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7 January 2021

Identification of the aminocatechol A-3253 as an in vitro poison of DNA topoisomerase I from Candida albicans

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7 January 2021

Structure-activity and structure-selectivity studies on diaminoquinazolines and other inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase

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7 January 2021

The gene encoding phosphoribosylaminoimidazole carboxylase (ADE2) is essential for growth of Cryptococcus neoformans in cerebrospinal fluid.

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7 January 2021

Identification of a new antifungal target site through a dual biochemical and molecular-genetics approach

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7 January 2021

Cispentacin, a new antifungal antibiotic. I. Production, isolation, physico-chemical properties and structure

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7 January 2021

Cispentacin, a new antifungal antibiotic. II. In vitro and in vivo antifungal activities

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7 January 2021

Anti-Candida activity of cispentacin: the active transport by amino acid permeases and possible mechanisms of action

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7 January 2021

The mechanism of antifungal action of (S)-2-amino-4-oxo-5-hydroxypentanoic acid, RI-331: the inhibition of homoserine dehydrogenase in Saccharomyces cerevisiae

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7 January 2021

A new methionine antagonist that has antifungal activity: mode of action.

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7 January 2021

Ornithine decarboxylase as an enzyme target for therapy

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7 January 2021

Ornithine decarboxylase in Pneumocystis carinii and implications for therapy

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7 January 2021

Fungal plasma membrane proton pumps as promising new antifungal targets

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7 January 2021

Genetics and biochemistry of yeast multidrug resistance

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7 January 2021

Emerging targets for the development of novel antifungal therapeutics

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7 January 2021

10.1016/S1369-5274(98)80087-8

Identifiers

DOI

1 reference

27 July 2017

1 reference