Mammalian nitric oxide synthases (Q33631306)

28 July 2017

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title

Mammalian nitric oxide synthases (English)

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28 July 2017

D J Stuehr

1

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28 July 2017

language of work or name

English

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publication date

1 May 1999

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Biochimica et Biophysica Acta

28 July 2017

published in

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28 July 2017

volume

1411

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28 July 2017

issue

2-3

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28 July 2017

page(s)

217-230

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Nitric oxide: a new paradigm for second messengers.

28 July 2017

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Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotozin contributes to islet cell DNA damage.

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Long-term potentiation is reduced in mice that are doubly mutant in endothelial and neuronal nitric oxide synthase

7 January 2021

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Multiple NF-kappaB enhancer elements regulate cytokine induction of the human inducible nitric oxide synthase gene

7 January 2021

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7 January 2021

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Simulation of the diffusion and reaction of endogenously produced nitric oxide

7 January 2021

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Neuronal nitric oxide synthase, a modular enzyme formed by convergent evolution: structure studies of a cysteine thiolate-liganded heme protein that hydroxylates L-arginine to produce NO. as a cellular signal.

7 January 2021

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Structure-function aspects in the nitric oxide synthases

7 January 2021

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Calmodulin is a subunit of nitric oxide synthase from macrophages

7 January 2021

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Endothelial nitric-oxide synthase. Expression in Escherichia coli, spectroscopic characterization, and role of tetrahydrobiopterin in dimer formation.

7 January 2021

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Human endothelial nitric oxide synthase: expression in Escherichia coli, coexpression with calmodulin, and characterization

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Expression of human inducible nitric oxide synthase in Escherichia coli

7 January 2021

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High-level expression of mouse inducible nitric oxide synthase in Escherichia coli requires coexpression with calmodulin

7 January 2021

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Prokaryotic expression of the heme- and flavin-binding domains of rat neuronal nitric oxide synthase as distinct polypeptides: identification of the heme-binding proximal thiolate ligand as cysteine-415.

7 January 2021

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Characterization of the inducible nitric oxide synthase oxygenase domain identifies a 49 amino acid segment required for subunit dimerization and tetrahydrobiopterin interaction

7 January 2021

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Oligomerization of endothelial nitric oxide synthase. Evidence for a dominant negative effect of truncation mutants

7 January 2021

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Calmodulin promotes dimerization of the oxygenase domain of human endothelial nitric-oxide synthase

7 January 2021

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Haem insertion, dimerization and reactivation of haem-free rat neuronal nitric oxide synthase.

7 January 2021

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Characterization of bovine endothelial nitric oxide synthase as a homodimer with down-regulated uncoupled NADPH oxidase activity: tetrahydrobiopterin binding kinetics and role of haem in dimerization

7 January 2021

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Characterization of the reductase domain of rat neuronal nitric oxide synthase generated in the methylotrophic yeast Pichia pastoris. Calmodulin response is complete within the reductase domain itself

7 January 2021

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The structure of nitric oxide synthase oxygenase domain and inhibitor complexes

7 January 2021

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Structure of nitric oxide synthase oxygenase dimer with pterin and substrate

7 January 2021

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An unusual yet strongly conserved flavoprotein reductase in bacteria and mammals

7 January 2021

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Characterization of bovine endothelial nitric oxide synthase expressed in E. coli.

7 January 2021

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Substrate binding and calmodulin binding to endothelial nitric oxide synthase coregulate its enzymatic activity

7 January 2021

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Comparative functioning of dihydro- and tetrahydropterins in supporting electron transfer, catalysis, and subunit dimerization in inducible nitric oxide synthase

7 January 2021

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Neuronal nitric-oxide synthase interaction with calmodulin-troponin C chimeras

7 January 2021

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Electron transfer and catalytic activity of nitric oxide synthases. Chimeric constructs of the neuronal, inducible, and endothelial isoforms

7 January 2021

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Three-dimensional structure of NADPH-cytochrome P450 reductase: prototype for FMN- and FAD-containing enzymes

7 January 2021

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Reconstitution of the second step in NO synthesis using the isolated oxygenase and reductase domains of macrophage NO synthase

7 January 2021

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Cytochrome P450cam: crystallography, oxygen activation, and electron transfer

7 January 2021

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Crystal structure of hemoprotein domain of P450BM-3, a prototype for microsomal P450's

7 January 2021

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Tetrahydrobiopterin binding to macrophage inducible nitric oxide synthase: heme spin shift and dimer stabilization by the potent pterin antagonist 4-amino-tetrahydrobiopterin.

7 January 2021

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Endothelial Nitric Oxide Synthase: Modulations of the Distal Heme Site Produced by Progressive N-Terminal Deletions

7 January 2021

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Delineation of the arginine- and tetrahydrobiopterin-binding sites of neuronal nitric oxide synthase

7 January 2021

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The crucial roles of Asp-314 and Thr-315 in the catalytic activation of molecular oxygen by neuronal nitric-oxide synthase. A site-directed mutagenesis study.

7 January 2021

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Mutagenesis of acidic residues in the oxygenase domain of inducible nitric-oxide synthase identifies a glutamate involved in arginine binding.

7 January 2021

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Mutation of Glu-361 in human endothelial nitric-oxide synthase selectively abolishes L-arginine binding without perturbing the behavior of heme and other redox centers

7 January 2021

1 reference

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Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin

7 January 2021

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Macrophage nitric oxide synthase: relationship between enzyme-bound tetrahydrobiopterin and synthase activity

7 January 2021

1 reference

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Tetrahydrobiopterin-Free Neuronal Nitric Oxide Synthase: Evidence for Two Identical Highly Anticooperative Pteridine Binding Sites†

7 January 2021

1 reference

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Particular ability of liver P450s3A to catalyze the oxidation of N omega-hydroxyarginine to citrulline and nitrogen oxides and occurrence in no synthases of a sequence very similar to the heme-binding sequence in P450s

7 January 2021

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Complementation analysis of mutants of nitric oxide synthase reveals that the active site requires two hemes

7 January 2021

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Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity

7 January 2021

1 reference

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Cysteine-200 of human inducible nitric oxide synthase is essential for dimerization of haem domains and for binding of haem, nitroarginine and tetrahydrobiopterin

7 January 2021

1 reference

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Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms

7 January 2021

1 reference

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Inducible nitric oxide synthase requires both the canonical calmodulin-binding domain and additional sequences in order to bind calmodulin and produce nitric oxide in the absence of free Ca2+

7 January 2021

1 reference

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Heme iron reduction and catalysis by a nitric oxide synthase heterodimer containing one reductase and two oxygenase domains

7 January 2021

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Effects of pH on the structure and function of neuronal nitric oxide synthase

7 January 2021

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Domain swapping in inducible nitric-oxide synthase. Electron transfer occurs between flavin and heme groups located on adjacent subunits in the dimer.

7 January 2021

1 reference

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The influence of chaotropic reagents on neuronal nitric oxide synthase and its flavoprotein module. Urea and guanidine hydrochloride stimulate NADPH-cytochrome c reductase activity of both proteins

7 January 2021

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EPR spectroscopic characterization of neuronal NO synthase

7 January 2021

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Endothelial nitric oxide synthase-dependent superoxide generation from adriamycin.

7 January 2021

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Active site topologies and cofactor-mediated conformational changes of nitric-oxide synthases

7 January 2021

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Calcium binding sites of calmodulin and electron transfer by neuronal nitric oxide synthase.

7 January 2021

1 reference

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The calmodulin-nitric oxide synthase interaction. Critical role of the calmodulin latch domain in enzyme activation

7 January 2021

1 reference

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The fourth EF-hand of calmodulin and its helix-loop-helix components: impact on calcium binding and enzyme activation

7 January 2021

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The calmodulin-binding domain of the inducible (macrophage) nitric oxide synthase

7 January 2021

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Different mechanisms for Ca2+ dissociation from complexes of calmodulin with nitric oxide synthase or myosin light chain kinase

7 January 2021

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The calmodulin binding domain of nitric oxide synthase and adenylyl cyclase

7 January 2021

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Distinct molecular recognition of calmodulin-binding sites in the neuronal and macrophage nitric oxide synthases: a surface plasmon resonance study.

7 January 2021

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Interaction of calmodulin with the inducible murine macrophage nitric oxide synthase

7 January 2021

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Circular dichroism and 1H NMR studies on the structures of peptides derived from the calmodulin-binding domains of inducible and endothelial nitric-oxide synthase in solution and in complex with calmodulin. Nascent alpha-helical structures are stabi

7 January 2021

1 reference

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Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial and inducible nitric oxide synthases

7 January 2021

1 reference

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An autoinhibitory control element defines calcium-regulated isoforms of nitric oxide synthase

7 January 2021

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The ferrous-dioxy complex of neuronal nitric oxide synthase. Divergent effects of L-arginine and tetrahydrobiopterin on its stability

7 January 2021

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Reaction of neuronal nitric-oxide synthase with oxygen at low temperature. Evidence for reductive activation of the oxy-ferrous complex by tetrahydrobiopterin.

7 January 2021

1 reference

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Expression in yeast and purification of functional macrophage nitric oxide synthase. Evidence for cysteine-194 as iron proximal ligand.

7 January 2021

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Electron paramagnetic resonance spectroscopy of the heme domain of inducible nitric oxide synthase: binding of ligands at the arginine site induces changes in the heme ligation geometry

7 January 2021

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Characterization by electron paramagnetic resonance of the interactions of L-arginine and L-thiocitrulline with the heme cofactor region of nitric oxide synthase

7 January 2021

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Stopped-flow analysis of CO and NO binding to inducible nitric oxide synthase

7 January 2021

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Heme coordination of NO in NO synthase

7 January 2021

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Interactions between substrate analogues and heme ligands in nitric oxide synthase

7 January 2021

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Characteristics of the nitric oxide synthase-catalyzed conversion of arginine to N-hydroxyarginine, the first oxygenation step in the enzymic synthesis of nitric oxide

7 January 2021

1 reference

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Reactivity of the flavin semiquinone of nitric oxide synthase in the oxygenation of arginine to NG-hydroxyarginine, the first step of nitric oxide synthesis.

7 January 2021

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Reduction of quinonoid dihydrobiopterin to tetrahydrobiopterin by nitric oxide synthase

7 January 2021

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Hydrogen peroxide-supported oxidation of NG-hydroxy-L-arginine by nitric oxide synthase

7 January 2021

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Formation of N delta-cyanoornithine from NG-hydroxy-L-arginine and hydrogen peroxide by neuronal nitric oxide synthase: implications for mechanism

7 January 2021

1 reference

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Analysis of neuronal NO synthase under single-turnover conditions: conversion of Nomega-hydroxyarginine to nitric oxide and citrulline

7 January 2021

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Nitric oxide complexes of inducible nitric oxide synthase: spectral characterization and effect on catalytic activity

7 January 2021

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Neuronal nitric oxide synthase self-inactivates by forming a ferrous-nitrosyl complex during aerobic catalysis

7 January 2021

1 reference

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Nitric oxide binding to the heme of neuronal nitric-oxide synthase links its activity to changes in oxygen tension

7 January 2021

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Characterization of neuronal nitric oxide synthase and a C415H mutant, purified from a baculovirus overexpression system

7 January 2021

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Nitric oxide in the sensory function of the carotid body

7 January 2021

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Substrate binding-induced changes in the EPR spectra of the ferrous nitric oxide complexes of neuronal nitric oxide synthase

7 January 2021

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Intracellular assembly of inducible NO synthase is limited by nitric oxide-mediated changes in heme insertion and availability

7 January 2021

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A synthetic peptide corresponding to the putative dihydrofolate reductase domain of nitric oxide synthase inhibits uncoupled NADPH oxidation

7 January 2021

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Cellular and molecular mechanisms of endothelial cell dysfunction

7 January 2021

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The first 35 amino acids and fatty acylation sites determine the molecular targeting of endothelial nitric oxide synthase into the Golgi region of cells: a green fluorescent protein study

7 January 2021

1 reference

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Nitric oxide synthases: which, where, how, and why?

7 January 2021

1 reference

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Immunosuppressant FK506 enhances phosphorylation of nitric oxide synthase and protects against glutamate neurotoxicity

7 January 2021

1 reference

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PDZ domain of neuronal nitric oxide synthase recognizes novel C-terminal peptide sequences

7 January 2021

1 reference

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Neuronal nitric oxide synthase and dystrophin-deficient muscular dystrophy

7 January 2021

1 reference

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PIN: an associated protein inhibitor of neuronal nitric oxide synthase

7 January 2021

1 reference

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Interaction of neuronal nitric-oxide synthase with caveolin-3 in skeletal muscle. Identification of a novel caveolin scaffolding/inhibitory domain

7 January 2021

1 reference

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Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling

7 January 2021

1 reference

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Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin

7 January 2021

1 reference

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Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity

7 January 2021

1 reference

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Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

7 January 2021

1 reference

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Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase

7 January 2021

1 reference

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Interaction between caveolin-1 and the reductase domain of endothelial nitric-oxide synthase. Consequences for catalysis

7 January 2021

1 reference

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Dynamic activation of endothelial nitric oxide synthase by Hsp90.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2899%2900016-X

Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats

7 January 2021

1 reference

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Structural analysis of porcine brain nitric oxide synthase reveals a role for tetrahydrobiopterin and L-arginine in the formation of an SDS-resistant dimer.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2899%2900016-X

Superoxide and peroxynitrite generation from inducible nitric oxide synthase in macrophages

7 January 2021

1 reference

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Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors

7 January 2021

1 reference

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Solution structure of a protein inhibitor of neuronal nitric oxide synthase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2899%2900016-X

7 January 2021

Why tetrahydrobiopterin?

1 reference

https://api.crossref.org/works/10.1016%2FS0005-2728%2899%2900016-X

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0005-2728(99)00016-X

1 reference

28 July 2017

1 reference