Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development (Q33669393)

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English	Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

1 reference

Europe PubMed Central

Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development (English)

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Europe PubMed Central

PubMed publication ID

28 July 2017

neurodegeneration

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based on heuristic

inferred from title

explanatory hypothesis

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based on heuristic

inferred from title

author name string

Floyd RA

1

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Europe PubMed Central

PubMed publication ID

28 July 2017

publication date

1 May 1999

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Europe PubMed Central

PubMed publication ID

28 July 2017

Free Radical Biology and Medicine

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Europe PubMed Central

PubMed publication ID

28 July 2017

26

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Europe PubMed Central

PubMed publication ID

28 July 2017

9-10

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Europe PubMed Central

PubMed publication ID

28 July 2017

1346-1355

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

Guam amyotrophic lateral sclerosis-parkinsonism-dementia linked to a plant excitant neurotoxin

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Enhanced production of superoxide anion by microglia from trisomy 16 mice

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of cytokines in acute neurodegeneration in the CNS.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Anti-inflammatory drugs and Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Reactive microglia express class I and class II major histocompatibility complex antigens in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Complement activation by beta-amyloid in Alzheimer disease

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Inflammatory cytokines within the central nervous system: sources, function, and mechanism of action

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: normal and pathological

1 reference

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7 January 2021

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inferred from DOI database lookup

Interleukin (IL) 1beta, IL-1 receptor antagonist, IL-10, and IL-13 gene expression in the central nervous system and anterior pituitary during systemic inflammation: pathophysiological implications

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

TNF-alpha- and IFN-gamma-mediated signal transduction pathways: effects on glial cell gene expression and function

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Amyloid-beta peptide-receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Detection of the membrane inhibitor of reactive lysis (CD59) in diseased neurons of Alzheimer brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

SP-40,40 is a constituent of Alzheimer's amyloid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

beta-Amyloid converts an acute phase injury response to chronic injury responses

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Regional accumulation of amyloid beta/A4 protein precursor in the gerbil brain following transient cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Posttraumatic premature Alzheimer's disease. Neuropathologic findings and pathogenetic considerations

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A case-control study of dementia of the Alzheimer type

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Head injury as a risk factor for Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative stress hypothesis in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Anoxia/reoxygenation induces hydroxyl free radical formation in brain microvessels

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inducible nitric oxide synthase gene expression in vascular cells after transient focal cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Nitric oxide synthase activity is elevated in brain microvessels in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Age influence on oxidative events during brain ischemia/reperfusion

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of free radicals in dementia of the Alzheimer type: a hypothesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Free radical damage, iron, and Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Radical AGEing in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Carbonyl-related posttranslational modification of neurofilament protein in the neurofibrillary pathology of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid beta-peptide.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative damage in Alzheimer's

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The oxidant stress hypothesis in Parkinson's disease: evidence supporting it

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7 January 2021

based on heuristic

inferred from DOI database lookup

Did radicals strike Lou Gehrig?

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Chronic Focal Epileptiform Discharges Induced by Injection of Iron Into Rat and Cat Cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Recurrent seizures induced by cortical iron injection: A model of posttraumatic epilepsy

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The effect of tocopherol and dimethyl sulfoxide on focal edema and lipid peroxidation induced by isocortical injection of ferrous chloride

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative mechanisms involved in kainate-induced cytotoxicity in cortical neurons

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxygen free radicals in rat limbic structures after kainate-induced seizures.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitochondrial DNA deletions in human brain: regional variability and increase with advanced age

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Aging, energy, and oxidative stress in neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Oxygen free radical involvement in ischemia and reperfusion injury to brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Central nervous system trauma and stroke. I. Biochemical considerations for oxygen radical formation and lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Central nervous system trauma and stroke. II. Physiological and pharmacological evidence for involvement of oxygen radicals and lipid peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Brain hydroxyl radical generation in acute experimental head injury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Hydroxyl radical production and lipid peroxidation parallels selective post-ischemic vulnerability in gerbil brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of free radicals in excitotoxicity in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Age-related regional changes in hydroxyl radical stress and antioxidants in gerbil brain

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Bioenergetic and oxidative stress in neurodegenerative diseases

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Bright and dark sides of nitric oxide in ischemic brain injury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inducible nitric oxide synthase gene expression in brain following cerebral ischemia

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Age effect on brain pH during ischemia/reperfusion and pH influence on peroxidation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumour necrosis factor-α induces superoxide anion generation in mitochondria of L929 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-inductive effects of TNF.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct evidence for tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Activation of human immunodeficiency virus long terminal repeat by arachidonic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Direct Effect of Ceramide on the Mitochondrial Electron Transport Chain Leads to Generation of Reactive Oxygen Species

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Rapid proteolysis of I kappa B-alpha is necessary for activation of transcription factor NF-kappa B

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Selective killing of cholinergic neurons by microglial activation in basal forebrain mixed neuronal/glial cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Induction of calcium-independent nitric oxide synthase activity in primary rat glial cultures.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanisms of nitric oxide-mediated neurotoxicity in primary brain cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Requirement for transcription factor IRF-1 in NO synthase induction in macrophages.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Cytokine-treated human neutrophils contain inducible nitric oxide synthase that produces nitration of ingested bacteria.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Alternative Splicing of Human Inducible Nitric-Oxide Synthase mRNA

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Apoptosis and necrosis: two distinct events induced, respectively, by mild and intense insults with N-methyl-D-aspartate or nitric oxide/superoxide in cortical cell cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Pathological implications of nitric oxide, superoxide and peroxynitrite formation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Widespread peroxynitrite-mediated damage in Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Nitric oxide-mediated mitochondrial damage in the brain: mechanisms and implications for neurodegenerative diseases.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased cerebrospinal fluid concentration of nitrite in Parkinson's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Decreased cerebrospinal fluid nitrate levels in Parkinson's disease, Alzheimer's disease and multiple system atrophy patients

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Immunologic NO synthase: elevation in severe AIDS dementia and induction by HIV-1 gp41.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

In vivo trapping of nitric oxide in the brain of neonatal rats treated with the HIV-1 envelope protein gp 120: protective effects of alpha-phenyl-tert-butylnitrone.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inverse association of anti-inflammatory treatments and Alzheimer's disease: initial results of a co-twin control study.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Inflammation and Alzheimer's disease pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2898%2900293-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Microglial cell activation in aging and Alzheimer disease: partial linkage with neurofibrillary tangle burden in the hippocampus

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1016/S0891-5849(98)00293-7

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

28 July 2017

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