2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity. (Q33698756)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

title

2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

4

1 reference

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9 April 2020

Karin Purshouse

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Gregory A Breuer

11

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Peter M Glazer

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

author name string

Parker L Sulkowski

1

1 reference

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9 April 2020

Christopher D Corso

2

1 reference

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9 April 2020

Nathaniel D Robinson

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Hanwen Bai

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Yanfeng Liu

7

1 reference

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9 April 2020

Ranjini K Sundaram

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Denise C Hegan

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Nathan R Fons

10

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Yuanbin Song

12

1 reference

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9 April 2020

Ketu Mishra-Gorur

13

1 reference

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9 April 2020

Henk M De Feyter

14

1 reference

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9 April 2020

Robin A de Graaf

15

1 reference

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9 April 2020

Yulia V Surovtseva

16

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Maureen Kachman

17

1 reference

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9 April 2020

Stephanie Halene

18

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Murat Günel

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

Ranjit S Bindra

21

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

language of work or name

English

0 references

publication date

1 February 2017

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

9 April 2020

published in

1 reference

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9 April 2020

volume

9

1 reference

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9 April 2020

issue

375

1 reference

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KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis

9 April 2020

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Regulation of the Nampt-mediated NAD salvage pathway and its therapeutic implications in pancreatic cancer.

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Distinct binding of BRCA2 BRC repeats to RAD51 generates differential DNA damage sensitivity

28 July 2018

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IDH mutations in cancer and progress toward development of targeted therapeutics

28 July 2018

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Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay

28 July 2018

1 reference

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miR-155 Overexpression Promotes Genomic Instability by Reducing High-fidelity Polymerase Delta Expression and Activating Error-Prone DSB Repair

28 July 2018

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Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer

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Noninvasive Quantification of 2-Hydroxyglutarate in Human Gliomas with IDH1 and IDH2 Mutations.

28 July 2018

1 reference

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Integrated genomic characterization of IDH1-mutant glioma malignant progression

28 July 2018

1 reference

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Treatment with a Small Molecule Mutant IDH1 Inhibitor Suppresses Tumorigenic Activity and Decreases Production of the Oncometabolite 2-Hydroxyglutarate in Human Chondrosarcoma Cells

28 July 2018

1 reference

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Hypoxia Induces Production of L-2-Hydroxyglutarate.

28 July 2018

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Hypoxia-Mediated Increases in L-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress

28 July 2018

1 reference

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YU238259 Is a Novel Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and Radiosensitization in Repair-Deficient Tumors.

28 July 2018

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Drugging ATR: progress in the development of specific inhibitors for the treatment of cancer.

28 July 2018

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Targeting cancer with kinase inhibitors

28 July 2018

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Isocitrate dehydrogenase 1 and 2 mutations induce BCL-2 dependence in acute myeloid leukemia

28 July 2018

1 reference

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Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors

28 July 2018

1 reference

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Synthetic lethal vulnerabilities of cancer

28 July 2018

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L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer.

28 July 2018

1 reference

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A phase I trial of veliparib (ABT-888) and temozolomide in children with recurrent CNS tumors: a pediatric brain tumor consortium report

28 July 2018

1 reference

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Tracing compartmentalized NADPH metabolism in the cytosol and mitochondria of mammalian cells

28 July 2018

1 reference

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The contribution of ketone bodies to basal and activity-dependent neuronal oxidation in vivo

28 July 2018

1 reference

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Hypoxic stress facilitates acute activation and chronic downregulation of fanconi anemia proteins.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5435119

OpenComet: an automated tool for comet assay image analysis.

28 July 2018

1 reference

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Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH.

28 July 2018

1 reference

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Increased sensitivity to radiochemotherapy in IDH1 mutant glioblastoma as demonstrated by serial quantitative MR volumetry

28 July 2018

1 reference

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Exome sequencing identifies frequent inactivating mutations in BAP1, ARID1A and PBRM1 in intrahepatic cholangiocarcinomas

28 July 2018

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What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

28 July 2018

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Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells

28 July 2018

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Enzymatic assay for quantitative analysis of (D)-2-hydroxyglutarate

28 July 2018

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Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma

28 July 2018

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Mutations in isocitrate dehydrogenase 1 and 2 occur frequently in intrahepatic cholangiocarcinomas and share hypermethylation targets with glioblastomas

28 July 2018

1 reference

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RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

28 July 2018

1 reference

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IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

28 July 2018

1 reference

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Hypoxia-induced epigenetic regulation and silencing of the BRCA1 promoter

28 July 2018

1 reference

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Nonhomologous end joining drives poly(ADP-ribose) polymerase (PARP) inhibitor lethality in homologous recombination-deficient cells.

28 July 2018

1 reference

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Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

28 July 2018

1 reference

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NAD+ depletion is necessary and sufficient for poly(ADP-ribose) polymerase-1-mediated neuronal death

28 July 2018

1 reference

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The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma

28 July 2018

1 reference

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Recurring mutations found by sequencing an acute myeloid leukemia genome

28 July 2018

1 reference

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Plasma and cerebrospinal fluid pharmacokinetics of ABT-888 after oral administration in non-human primates

28 July 2018

1 reference

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IDH1 and IDH2 mutations in gliomas

28 July 2018

1 reference

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The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells

28 July 2018

1 reference

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ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models

28 July 2018

1 reference

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Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining

28 July 2018

1 reference

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Molecular and biochemical characterization of xrs mutants defective in Ku80.

28 July 2018

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Inhibition of prolyl 4-hydroxylase by oxalyl amino acid derivatives in vitro, in isolated microsomes and in embryonic chicken tissues

28 July 2018

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DNA REPAIR. Drugging DNA repair.

28 July 2018

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Comparative Analysis of Methods for Detecting Isocitrate Dehydrogenase 1 and 2 Mutations and Their Metabolic Consequence, 2-Hydroxyglutarate, in Different Neoplasms.

30 October 2018

1 reference

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Extreme Vulnerability of IDH1 Mutant Cancers to NAD+ Depletion.

30 October 2018

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Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells.

30 October 2018

1 reference

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Olaparib combined with chemotherapy for recurrent platinum-sensitive ovarian cancer: a randomised phase 2 trial.

30 October 2018

1 reference

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KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor

30 October 2018

1 reference

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Phase I/Ib study of olaparib and carboplatin in BRCA1 or BRCA2 mutation-associated breast or ovarian cancer with biomarker analyses

30 October 2018

1 reference

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The combination of IDH1 mutations and MGMT methylation status predicts survival in glioblastoma better than either IDH1 or MGMT alone.

30 October 2018

1 reference

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MYC-driven accumulation of 2-hydroxyglutarate is associated with breast cancer prognosis.

30 October 2018

1 reference

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Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function

30 October 2018

1 reference

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Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation

30 October 2018

1 reference

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An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

30 October 2018

1 reference

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IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

30 October 2018

1 reference

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Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

30 October 2018

1 reference

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Functional restoration of BRCA2 protein by secondary BRCA2 mutations in BRCA2-mutated ovarian carcinoma

30 October 2018

1 reference

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An integrated genomic analysis of human glioblastoma multiforme

30 October 2018

1 reference

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Basal repression of BRCA1 by multiple E2Fs and pocket proteins at adjacent E2F sites

30 October 2018

1 reference

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Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

30 October 2018

1 reference

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XRCC3 promotes homology-directed repair of DNA damage in mammalian cells

30 October 2018

1 reference

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Tumor growth inhibition by olaparib in BRCA2 germline-mutated patient-derived ovarian cancer tissue xenografts

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28148839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The comet assay: a method to measure DNA damage in individual cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/28148839

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.AAL2463

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:28148839%20AND%20SRC:MED&resulttype=core&format=json

9 April 2020

PubMed publication ID

28148839

1 reference