Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling. (Q33724411)

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English	Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling.	scientific article

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10 January 2020

Akt-dependent cell size regulation by the adhesion molecule on glia occurs independently of phosphatidylinositol 3-kinase and Rheb signaling (English)

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10 January 2020

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David H. Gutmann

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10 January 2020

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Danielle K Scheidenhelm

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10 January 2020

Jennifer Cresswell

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10 January 2020

Carrie A Haipek

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10 January 2020

Timothy P Fleming

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10 January 2020

Robert W Mercer

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10 January 2020

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1 April 2005

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10 January 2020

Molecular and Cellular Biology

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10 January 2020

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10 January 2020

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10 January 2020

3151-3162

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10 January 2020

Tsc2 is not a critical target of Akt during normal Drosophila development

1 reference

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21 June 2018

Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity

1 reference

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21 June 2018

Loss of tuberous sclerosis complex 1 (Tsc1) expression results in increased Rheb/S6K pathway signaling important for astrocyte cell size regulation

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21 June 2018

Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway

1 reference

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21 June 2018

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21 June 2018

Advances in protein kinase B signalling: AKTion on multiple fronts

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21 June 2018

PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion

1 reference

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21 June 2018

mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo

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PI3 kinase enhancer–Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis

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21 June 2018

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

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21 June 2018

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

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21 June 2018

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

1 reference

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21 June 2018

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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21 June 2018

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

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21 June 2018

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

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21 June 2018

Molecular mechanisms of Na/K-ATPase-mediated signal transduction

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21 June 2018

T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression

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21 June 2018

Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

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21 June 2018

Cell adhesion regulates platelet-derived growth factor-induced MAP kinase and PI-3 kinase activation in stellate cells

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21 June 2018

Akt regulates growth by directly phosphorylating Tsc2

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21 June 2018

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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21 June 2018

Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin

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21 June 2018

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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21 June 2018

Mouse glioma gene expression profiling identifies novel human glioma-associated genes

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21 June 2018

Activation of the PKB/AKT pathway by ICAM-2.

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21 June 2018

Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members

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21 June 2018

Characterization of Rheb functions using yeast and mammalian systems

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21 June 2018

Identification of cadherin-11 down-regulation as a common response of astrocytoma cells to transforming growth factor-alpha

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21 June 2018

Growth factor-stimulated phosphorylation of Akt and p70(S6K) is differentially inhibited by LY294002 and Wortmannin

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21 June 2018

Pike. A nuclear gtpase that enhances PI3kinase activity and is regulated by protein 4.1N

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Involvement of Src and epidermal growth factor receptor in the signal-transducing function of Na+/K+-ATPase

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21 June 2018

The PI3K-PDK1 connection: more than just a road to PKB

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21 June 2018

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

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21 June 2018

Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB.

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21 June 2018

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor

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21 June 2018

NCAM stimulates the Ras-MAPK pathway and CREB phosphorylation in neuronal cells

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21 June 2018

Overexpression of a transmembrane isoform of neural cell adhesion molecule alters the invasiveness of rat CNS-1 glioma

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21 June 2018

Phosphorylation and activation of p70s6k by PDK1

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3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

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21 June 2018

The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation.

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21 June 2018

E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms

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21 June 2018

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

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21 June 2018

Expression of the beta 1 and beta 2(AMOG) subunits of the Na,K-ATPase in neural tissues: cellular and developmental distribution patterns.

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21 June 2018

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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21 June 2018

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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21 June 2018

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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21 June 2018

Gene expression of neural cell adhesion molecule L1 in malignant gliomas and biological significance of L1 in glioma invasion.

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A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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21 June 2018

The neural cell adhesion molecule (N-CAM) inhibits proliferation in primary cultures of rat astrocytes

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21 June 2018

Degeneration of neural cells in the central nervous system of mice deficient in the gene for the adhesion molecule on Glia, the beta 2 subunit of murine Na,K-ATPase

1 reference

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21 June 2018

Functional characterization of beta isoforms of murine Na,K-ATPase. The adhesion molecule on glia (AMOG/beta 2), but not beta 1, promotes neurite outgrowth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

21 June 2018

A role for the beta-subunit in the expression of functional Na+-K+-ATPase in Xenopus oocytes

1 reference

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21 June 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

21 June 2018

The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

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Reciprocal regulation of MelCAM and AKT in human melanoma

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30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

30 October 2018

Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

30 October 2018

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

30 October 2018

The Adhesion Molecule on Glia (AMOG) Is Widely Expressed by Astrocytes in Developing and Adult Mouse Brain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

30 October 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

30 October 2018

L1 expressed by glioma cells promotes adhesion but not migration

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30 October 2018

Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases

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30 October 2018

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

30 October 2018

Failure to farnesylate Rheb protein contributes to the enrichment of G0/G1 phase cells in the Schizosaccharomyces pombe farnesyltransferase mutant

1 reference

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30 October 2018

Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size

1 reference

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30 October 2018

The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation

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30 October 2018

Gab1 mediates neurite outgrowth, DNA synthesis, and survival in PC12 cells

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30 October 2018

Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4.

1 reference

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30 October 2018

Multiple signal transduction pathways link Na+/K+-ATPase to growth-related genes in cardiac myocytes. The roles of Ras and mitogen-activated protein kinases

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30 October 2018

Structure and expression of the human Na,K-ATPase beta 2-subunit gene

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30 October 2018

Partial inhibition of Na+/K+-ATPase by ouabain induces the Ca2+-dependent expressions of early-response genes in cardiac myocytes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

30 October 2018

The Drosophila insulin receptor is required for normal growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1069598

30 October 2018

The adhesion molecule on glia (AMOG) incorporated into lipid vesicles binds to subpopulations of neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/15798201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential regulation of Na/K-ATPase alpha-subunit isoform gene expressions in cardiac myocytes by ouabain and other hypertrophic stimuli

1 reference

https://pubmed.ncbi.nlm.nih.gov/15798201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Opinion: Searching for the elusive targets of farnesyltransferase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15798201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intracellular reactive oxygen species mediate the linkage of Na+/K+-ATPase to hypertrophy and its marker genes in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/15798201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ouabain interaction with cardiac Na+/K+-ATPase initiates signal cascades independent of changes in intracellular Na+ and Ca2+ concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/15798201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

N-cadherin influences migration of oligodendrocytes on astrocyte monolayers

1 reference

https://pubmed.ncbi.nlm.nih.gov/15798201

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.25.8.3151-3162.2005

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798201%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

release_qnxjmi2o35ddhcyapt3vvcujmu

1 reference

https://api.fatcat.wiki/v0/release/qnxjmi2o35ddhcyapt3vvcujmu

24 November 2022

based on heuristic

mapped directly with Wikidata item

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798201%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15798201%20AND%20SRC:MED&resulttype=core&format=json

10 January 2020

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