Presenilins: molecular switches between proteolysis and signal transduction (Q33730415)

29 July 2017

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title

Presenilins: molecular switches between proteolysis and signal transduction (English)

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29 July 2017

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Annaert W

1

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29 July 2017

De Strooper B

series ordinal

2

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29 July 2017

language of work or name

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1 October 1999

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29 July 2017

published in

Trends in Neurosciences

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29 July 2017

volume

22

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29 July 2017

issue

10

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29 July 2017

page(s)

439-443

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

29 July 2017

cites work

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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7 January 2021

Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants.

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Presenilin is required for activity and nuclear access of Notch in Drosophila

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7 January 2021

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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7 January 2021

Phosphorylation, subcellular localization, and membrane orientation of the Alzheimer's disease-associated presenilins.

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7 January 2021

Protein topology of presenilin 1

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7 January 2021

Evidence for a six-transmembrane domain structure of presenilin 1.

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7 January 2021

Membrane topology of the C. elegans SEL-12 presenilin

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7 January 2021

Additional evidence for an eight-transmembrane-domain topology for Caenorhabditis elegans and human presenilins

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7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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7 January 2021

Destabilization of beta-catenin by mutations in presenilin-1 potentiates neuronal apoptosis

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7 January 2021

Direct association of presenilin-1 with beta-catenin

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7 January 2021

Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

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7 January 2021

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

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7 January 2021

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

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7 January 2021

Alzheimer presenilins in the nuclear membrane, interphase kinetochores, and centrosomes suggest a role in chromosome segregation

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7 January 2021

Aggresomes: a cellular response to misfolded proteins

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7 January 2021

Proteolytic fragments of Alzheimer's disease-associated presenilin 1 are present in synaptic organelles and growth cone membranes of rat brain

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7 January 2021

Enrichment of presenilin 1 peptides in neuronal large dense-core and somatodendritic clathrin-coated vesicles

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7 January 2021

Light and electron microscopic localization of presenilin-1 in primate brain.

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7 January 2021

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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7 January 2021

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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7 January 2021

Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide

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7 January 2021

The Notch1 receptor is cleaved constitutively by a furin-like convertase

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7 January 2021

Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis

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7 January 2021

The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease

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7 January 2021

Seeding "one-dimensional crystallization" of amyloid: a pathogenic mechanism in Alzheimer's disease and scrapie?

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7 January 2021

Alzheimer's disease: genotypes, phenotypes, and treatments

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7 January 2021

Effects of PS1 deficiency on membrane protein trafficking in neurons

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7 January 2021

Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene

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7 January 2021

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

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7 January 2021

LIN-12/Notch signaling: lessons from worms and flies

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7 January 2021

Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos

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7 January 2021

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

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7 January 2021

Nuclear access and action of notch in vivo

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7 January 2021

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7 January 2021

Skeletal and CNS defects in Presenilin-1-deficient mice

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7 January 2021

Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

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7 January 2021

Presenilin-1 deficiency leads to loss of Cajal-Retzius neurons and cortical dysplasia similar to human type 2 lissencephaly

1 reference

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7 January 2021

Transgenic Drosophila expressing human amyloid precursor protein show gamma-secretase activity and a blistered-wing phenotype

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7 January 2021

Fe65 and the protein network centered around the cytosolic domain of the Alzheimer's beta-amyloid precursor protein

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7 January 2021

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

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7 January 2021

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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7 January 2021

Intracellular generation and accumulation of amyloid beta-peptide terminating at amino acid 42.

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7 January 2021

Alzheimer's A beta(1-42) is generated in the endoplasmic reticulum/intermediate compartment of NT2N cells

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https://api.crossref.org/works/10.1016%2FS0166-2236%2899%2901455-1

7 January 2021

Interaction between amyloid precursor protein and presenilins in mammalian cells: Implications for the pathogenesis of Alzheimer disease

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2899%2901455-1

7 January 2021

Formation of stable complexes between two Alzheimer's disease gene products: presenilin-2 and beta-amyloid precursor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2899%2901455-1

7 January 2021

Evidence for a physical interaction between presenilin and Notch

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2899%2901455-1

7 January 2021

Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2899%2901455-1

7 January 2021

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2899%2901455-1

7 January 2021

Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs

1 reference

https://api.crossref.org/works/10.1016%2FS0166-2236%2899%2901455-1

7 January 2021

Molecular identification of the sterol-regulated luminal protease that cleaves SREBPs and controls lipid composition of animal cells

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7 January 2021

10.1016/S0166-2236(99)01455-1

Identifiers

DOI

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29 July 2017

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