Progress toward valid transgenic mouse models for Alzheimer's disease (Q33760959)

29 July 2017

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title

Progress toward valid transgenic mouse models for Alzheimer's disease (English)

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29 July 2017

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Guénette SY

1

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29 July 2017

Tanzi RE

series ordinal

2

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29 July 2017

publication date

1 March 1999

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29 July 2017

published in

Neurobiology of Aging

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29 July 2017

volume

20

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29 July 2017

issue

2

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29 July 2017

page(s)

201-211

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Mutant Mice and Neuroscience: Recommendations Concerning Genetic Background

29 July 2017

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Genetic modification of the phenotypes produced by amyloid precursor protein overexpression in transgenic mice.

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No association detected between very-low-density lipoprotein receptor (VLDL-R) and late-onset Alzheimer's disease in Hong Kong Chinese.

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid beta-protein in both transfected cells and transgenic mice

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Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease

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Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations

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7 January 2021

Proteolytical processing of mutated human amyloid precursor protein in transgenic mice

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7 January 2021

Association of apolipoprotein E4 with sporadic Alzheimer's disease is more pronounced in early onset type.

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7 January 2021

An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos.

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7 January 2021

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway

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Polygenic determinants of Alzheimer's disease: modulation of the risk by alpha-1-antichymotrypsin.

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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

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7 January 2021

Alpha-antichymotrypsin gene polymorphism and risk for Alzheimer's disease in the Spanish population.

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7 January 2021

Evidence for normal aging of the septo-hippocampal cholinergic system in apoE (-/-) mice but impaired clearance of axonal degeneration products following injury

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7 January 2021

No association between the very low density lipoprotein receptor gene and late-onset Alzheimer's disease nor interaction with the apolipoprotein E gene in population-based and clinic samples

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7 January 2021

M1 muscarinic agonist treatment reverses cognitive and cholinergic impairments of apolipoprotein E-deficient mice.

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7 January 2021

Differential effects of the swedish mutant amyloid precursor protein on beta-amyloid accumulation and secretion in neurons and nonneuronal cells

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7 January 2021

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

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7 January 2021

Abeta-peptide length and apolipoprotein E genotype in Alzheimer's disease

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7 January 2021

Tau mutations cause frontotemporal dementias

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7 January 2021

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

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7 January 2021

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.

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7 January 2021

No genetic effect of alpha1-antichymotrypsin in Alzheimer disease.

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7 January 2021

No association between alpha 1-antichymotrypsin and familial Alzheimer's disease.

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7 January 2021

Transgenic mouse brain histopathology resembles early Alzheimer's disease

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7 January 2021

Early Alzheimer disease-like histopathology increases in frequency with age in mice transgenic for beta-APP751.

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7 January 2021

The alternatively spliced Kunitz protease inhibitor domain alters amyloid beta protein precursor processing and amyloid beta protein production in cultured cells

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7 January 2021

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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7 January 2021

ApoE genotype is a risk factor in nonpresenilin early-onset Alzheimer's disease families

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7 January 2021

Mutant and native human beta-amyloid precursor proteins in transgenic mouse brain

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Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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7 January 2021

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7 January 2021

Abeta deposition is associated with neuropil changes, but not with overt neuronal loss in the human amyloid precursor protein V717F (PDAPP) transgenic mouse.

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7 January 2021

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

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7 January 2021

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7 January 2021

Peptides containing the RERMS sequence of amyloid beta/A4 protein precursor bind cell surface and promote neurite extension

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7 January 2021

Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease

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7 January 2021

Genetic association studies between Alzheimer's disease and two polymorphisms in the low density lipoprotein receptor-related protein gene.

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7 January 2021

Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain

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7 January 2021

The Alzheimer's A beta peptide induces neurodegeneration and apoptotic cell death in transgenic mice

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7 January 2021

Altered metabolism of familial Alzheimer's disease-linked amyloid precursor protein variants in yeast artificial chromosome transgenic mice.

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7 January 2021

Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice [corrected]

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7 January 2021

Synergy between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset confirmed Alzheimer's disease

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7 January 2021

Sequence of deposition of heterogeneous amyloid beta-peptides and APO E in Down syndrome: implications for initial events in amyloid plaque formation.

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7 January 2021

The E280A presenilin 1 Alzheimer mutation produces increased A beta 42 deposition and severe cerebellar pathology

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7 January 2021

Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease.

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7 January 2021

Confirmation of association between the e4 allele of apolipoprotein E and Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Lack of beta-amyloidosis in transgenic mice expressing low levels of familial Alzheimer's disease missense mutations

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7 January 2021

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease

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7 January 2021

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

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7 January 2021

Memory-enhancing effects of secreted forms of the beta-amyloid precursor protein in normal and amnestic mice.

1 reference

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7 January 2021

The amyloid protein precursor of Alzheimer's disease is a mediator of the effects of nerve growth factor on neurite outgrowth

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7 January 2021

Early phenotypic changes in transgenic mice that overexpress different mutants of amyloid precursor protein in brain

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7 January 2021

Expression in brain of amyloid precursor protein mutated in the alpha-secretase site causes disturbed behavior, neuronal degeneration and premature death in transgenic mice.

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7 January 2021

Relative increase in Alzheimer's disease of soluble forms of cerebral Abeta amyloid protein precursor containing the Kunitz protease inhibitory domain.

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7 January 2021

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7 January 2021

Synaptotrophic effects of human amyloid β protein precursors in the cortex of transgenic mice

1 reference

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7 January 2021

Alpha 1-antichymotrypsin gene polymorphism and risk for Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

No association between the alpha 1-antichymotrypsin A allele and Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Implication of α1-antichymotrypsin polymorphism in familial Alzheimer's disease

1 reference

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7 January 2021

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1 reference

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7 January 2021

Genetic association of the very low density lipoprotein (VLDL) receptor gene with sporadic Alzheimer's disease

1 reference

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7 January 2021

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

1 reference

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7 January 2021

Mutant presenilin 2 transgenic mouse: effect on an age-dependent increase of amyloid beta-protein 42 in the brain

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7 January 2021

Evidence for association of HLA-A2 allele with onset age of Alzheimer's disease.

1 reference

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7 January 2021

Basal forebrain neuronal loss in mice lacking neurotrophin receptor p75.

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7 January 2021

Alzheimer's disease: genetic studies and transgenic models

1 reference

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7 January 2021

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression

1 reference

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7 January 2021

Formation of beta-amyloid protein deposits in brains of transgenic mice

1 reference

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7 January 2021

Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of females

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7 January 2021

Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence

1 reference

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7 January 2021

Increase of synaptic density and memory retention by a peptide representing the trophic domain of the amyloid beta/A4 protein precursor

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the beta-amyloid protein precursor of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

The expression of amyloid beta protein precursor protects nerve cells from beta-amyloid and glutamate toxicity and alters their interaction with the extracellular matrix

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

No association between the K variant of the butyrylcholinesterase gene and pathologically confirmed Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

A severe loss of choline acetyltransferase in the frontal cortex of Alzheimer patients carrying apolipoprotein epsilon 4 allele

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1 reference

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7 January 2021

Stable association of presenilin derivatives and absence of presenilin interactions with APP.

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https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Survival of cholinergic forebrain neurons in developing p75NGFR-deficient mice

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7 January 2021

Deposits of Amyloid β Protein in the Central Nervous System of Transgenic Mice

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7 January 2021

Amyloidogenic role of cytokine TGF-beta1 in transgenic mice and in Alzheimer's disease

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https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

Alpha1-antichymotrypsin polymorphism in Japanese cases of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0197-4580%2899%2900042-1

7 January 2021

The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin

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7 January 2021

10.1016/S0197-4580(99)00042-1

Identifiers

DOI

1 reference

29 July 2017

1 reference