Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks (Q33781697)

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English	Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

29 July 2017

Neutrophils stimulated with a variety of chemoattractants exhibit rapid activation of p21-activated kinases (Paks): separate signals are required for activation and inactivation of paks (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

R Huang

1

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Europe PubMed Central

PubMed publication ID

29 July 2017

J P Lian

2

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Europe PubMed Central

PubMed publication ID

29 July 2017

D Robinson

3

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Europe PubMed Central

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29 July 2017

J A Badwey

4

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Europe PubMed Central

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29 July 2017

language of work or name

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publication date

1 December 1998

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Europe PubMed Central

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29 July 2017

Molecular and Cellular Biology

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29 July 2017

18

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Europe PubMed Central

PubMed publication ID

29 July 2017

12

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

7130-7138

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Rhodopsin-family receptors associate with small G proteins to activate phospholipase D.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

1 reference

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4 July 2018

A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways

1 reference

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4 July 2018

Interaction of a G-protein beta-subunit with a conserved sequence in Ste20/PAK family protein kinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Multistep navigation and the combinatorial control of leukocyte chemotaxis

1 reference

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4 July 2018

Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins

1 reference

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4 July 2018

Signalling through the lipid products of phosphoinositide-3-OH kinase

1 reference

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4 July 2018

A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis

1 reference

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4 July 2018

Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p38 mitogen-activated protein kinases

1 reference

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4 July 2018

Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.

1 reference

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4 July 2018

p21-activated kinase has substrate specificity similar to Acanthamoeba myosin I heavy chain kinase and activates Acanthamoeba myosin I

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Myosin I overexpression impairs cell migration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Regulation of phosphorylation pathways by p21 GTPases. The p21 Ras-related Rho subfamily and its role in phosphorylation signalling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Activation of myosin-I by members of the Ste20p protein kinase family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

The renaturable 69- and 63-kDa protein kinases that undergo rapid activation in chemoattractant-stimulated guinea pig neutrophils are p21-activated kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Signal transduction and actin filament organization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Tyrosine phosphorylation and activation of a new mitogen-activated protein (MAP)-kinase cascade in human neutrophils stimulated with various agonists

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Synergistic activation of PtdIns 3-kinase by tyrosine-phosphorylated peptide and beta gamma-subunits of GTP-binding proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Specific interactions of chemoattractant factor receptors with G-proteins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Neutrophils stimulated with a chemotactic peptide or a phorbol ester exhibit different alterations in the activities of a battery of protein kinases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

A brain serine/threonine protein kinase activated by Cdc42 and Rac1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases

1 reference

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C5A anaphylatoxin and its seven transmembrane-segment receptor

1 reference

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4 July 2018

A novel serine kinase activated by rac1/CDC42Hs-dependent autophosphorylation is related to PAK65 and STE20

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Regulation of leukocyte rolling and adhesion to high endothelial venules through the cytoplasmic domain of L-selectin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors

1 reference

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4 July 2018

Rho Family GTPases Regulate p38 Mitogen-activated Protein Kinase through the Downstream Mediator Pak1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Signaling functions of L-selectin. Enhancement of tyrosine phosphorylation and activation of MAP kinase

1 reference

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4 July 2018

Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

NADH oxidase from guinea pig polymorphonuclear leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

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Platelet activating factor: a biologically active phosphoglyceride

1 reference

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4 July 2018

Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Irreversible inhibition of v-src tyrosine kinase activity by herbimycin A and its abrogation by sulfhydryl compounds

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Chemoattractant-stimulated GTPase activity is decreased on membranes from polymorphonuclear leukocytes incubated in chemoattractant.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Direct demonstration of the lectin activity of gp90MEL, a lymphocyte homing receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Receptor class desensitization of leukocyte chemoattractant receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

1-O-hexadecyl-2-acetyl-sn-glycero-3-phospho (N,N,N trimethyl) hexanolamine: an analogue of platelet-activating factor with partial agonist activity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

4 July 2018

A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

30 October 2018

Contrasting responses to multiple chemotactic stimuli in transendothelial migration: heterologous desensitization in neutrophils and augmentation of migration in eosinophils.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=109294

30 October 2018

Importance of MEK in neutrophil microbicidal responsiveness

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: lack of requirements of calcium mobilization and protein kinase C activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation of neutrophils with a chemoattractant activates several novel protein kinases that can catalyze the phosphorylation of peptides derived from the 47-kDa protein component of the phagocyte oxidase and myristoylated alanine-rich C kinase su

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Receptor-mediated activation of multiple serine/threonine kinases in human leukocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of two different forms of mitogen-activated protein kinase kinase induced in polymorphonuclear leukocytes following stimulation by N-formylmethionyl-leucyl-phenylalanine or granulocyte-macrophage colony-stimulating factor

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Serine/threonine kinase activation in human neutrophils: relationship to tyrosine phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of p21-CDC42/Rac-activated kinases by CD28 signaling: p21-activated kinase (PAK) and MEK kinase 1 (MEKK1) may mediate the interplay between CD3 and CD28 signals

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Products of sphingolipid catabolism block activation of the p21-activated protein kinases in neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of the p21-activated protein kinases from neutrophils with an antibody that reacts with the N-terminal region of Pak 1

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential effects of a mitogen-activated protein kinase kinase inhibitor on human neutrophil responses to chemotactic factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The phosphatidylinositol 3-kinase inhibitor wortmannin markedly reduces chemotactic peptide-induced locomotion and increases in cytoskeletal actin in human neutrophils

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p38 mitogen-activated protein kinase activation is required for human neutrophil function triggered by TNF-alpha or FMLP stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/9819399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1128/MCB.18.12.7130

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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