Construction and characterization of a temperature-sensitive human immunodeficiency virus type 1 reverse transcriptase mutant (Q33782366)

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10 November 2019

title

Construction and characterization of a temperature-sensitive human immunodeficiency virus type 1 reverse transcriptase mutant (English)

1 reference

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10 November 2019

author name string

M Huang

1

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10 November 2019

R Zensen

2

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10 November 2019

M Cho

3

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10 November 2019

M A Martin

4

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10 November 2019

publication date

1 March 1998

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10 November 2019

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10 November 2019

volume

72

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10 November 2019

issue

3

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10 November 2019

page(s)

2047-2054

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Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization

10 November 2019

cites work

1 reference

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(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants [...]

4 July 2018

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Human immunodeficiency virus reverse transcriptase. Functional mutants obtained by random mutagenesis coupled with genetic selection in Escherichia coli

4 July 2018

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Viral resistance and the selection of antiretroviral combinations

4 July 2018

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Requirements for incorporation of Pr160gag-pol from human immunodeficiency virus type 1 into virus-like particles.

4 July 2018

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The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

4 July 2018

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Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents

4 July 2018

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Clustered charged-to-alanine mutagenesis of poliovirus RNA-dependent RNA polymerase yields multiple temperature-sensitive mutants defective in RNA synthesis

4 July 2018

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Targeted construction of temperature-sensitive mutations in vaccinia virus by replacing clustered charged residues with alanine

4 July 2018

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Evidence for a functional interaction between the V1/V2 and C4 domains of human immunodeficiency virus type 1 envelope glycoprotein gp120.

4 July 2018

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The activity of the protease of human immunodeficiency virus type 1 is initiated at the membrane of infected cells before the release of viral proteins and is required for release to occur with maximum efficiency.

4 July 2018

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Identification and characterization of a temperature-sensitive mutant of human immunodeficiency virus type 1 by alanine scanning mutagenesis of the integrase gene

4 July 2018

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Crystal structure of human immunodeficiency virus type 1 reverse transcriptase complexed with double-stranded DNA at 3.0 A resolution shows bent DNA

4 July 2018

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Mutational sensitivity patterns define critical residues in the palm subdomain of the reverse transcriptase of human immunodeficiency virus type 1.

4 July 2018

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The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1

4 July 2018

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The K65R mutant reverse transcriptase of HIV-1 cross-resistant to 2', 3'-dideoxycytidine, 2',3'-dideoxy-3'-thiacytidine, and 2',3'-dideoxyinosine shows reduced sensitivity to specific dideoxynucleoside triphosphate inhibitors in vitro

4 July 2018

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Site-directed mutagenesis of HIV reverse transcriptase to probe enzyme processivity and drug binding

4 July 2018

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Structural basis of asymmetry in the human immunodeficiency virus type 1 reverse transcriptase heterodimer

4 July 2018

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Sensitivity of wild-type human immunodeficiency virus type 1 reverse transcriptase to dideoxynucleotides depends on template length; the sensitivity of drug-resistant mutants does not.

4 July 2018

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Resistance to 2',3'-dideoxycytidine conferred by a mutation in codon 65 of the human immunodeficiency virus type 1 reverse transcriptase

4 July 2018

1 reference

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Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

4 July 2018

1 reference

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HIV resistance to reverse transcriptase inhibitors

4 July 2018

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p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing protease

4 July 2018

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Rapid and efficient site-specific mutagenesis without phenotypic selection

4 July 2018

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In vitro mutagenesis identifies a region within the envelope gene of the human immunodeficiency virus that is critical for infectivity

4 July 2018

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Biosynthesis, cleavage, and degradation of the human immunodeficiency virus 1 envelope glycoprotein gp160.

4 July 2018

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Co-expression of the subunits of the heterodimer of HIV-1 reverse transcriptase in Escherichia coli.

4 July 2018

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Infectious potential of human immunodeficiency virus type 1 reverse transcriptase mutants with altered inhibitor sensitivity

4 July 2018

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HIV-1 reverse transcriptase: crystallization and analysis of domain structure by limited proteolysis.

4 July 2018

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Expression of soluble, enzymatically active, human immunodeficiency virus reverse transcriptase in Escherichia coli and analysis of mutants

4 July 2018

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AIDS virus reverse transcriptase defined by high level expression in Escherichia coli

4 July 2018

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4 July 2018

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Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.

4 July 2018

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Contribution of NF-kappa B and Sp1 binding motifs to the replicative capacity of human immunodeficiency virus type 1: distinct patterns of viral growth are determined by T-cell types

4 July 2018

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A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor

4 July 2018

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Mutations within the human immunodeficiency virus type 1 gp160 envelope glycoprotein alter its intracellular transport and processing

4 July 2018

1 reference

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Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase

4 July 2018

1 reference

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HIV reverse transcriptase structure-function relationships

4 July 2018

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Mutational analysis of two conserved sequence motifs in HIV-1 reverse transcriptase

4 July 2018

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HIV-1 reverse transcriptase purified from a recombinant strain of Escherichia coli.

4 July 2018

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Dimerization of human immunodeficiency virus type 1 reverse transcriptase. A target for chemotherapeutic intervention.

4 July 2018

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Stabilization and activation of recombinant human immunodeficiency virus-1 reverse transcriptase-P66

4 July 2018

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Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI.

4 July 2018

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Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene

4 July 2018

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Systematic mutational analysis of the yeast ACT1 gene

4 July 2018

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The nonmyristylated Pr160gag-pol polyprotein of human immunodeficiency virus type 1 interacts with Pr55gag and is incorporated into viruslike particles

4 July 2018

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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor

4 July 2018

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Cassette mutagenesis of the reverse transcriptase of human immunodeficiency virus type 1

4 July 2018

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Mutational analysis of the fingers domain of human immunodeficiency virus type 1 reverse transcriptase

4 July 2018

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Mutational analysis of the fingers and palm subdomains of human immunodeficiency virus type-1 (HIV-1) reverse transcriptase

4 July 2018

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30 October 2018

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Structural requirements for bacterial expression of stable, enzymatically active fusion proteins containing the human immunodeficiency virus reverse transcriptase

30 October 2018

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Mutating the “primer grip” of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization

30 October 2018

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12 December 2020

Role of the "helix clamp" in HIV-1 reverse transcriptase catalytic cycling as revealed by alanine-scanning mutagenesis

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Complete mutagenesis of the HIV-1 protease

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Form, function, and use of retroviral gag proteins

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