The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization (Q33800561)

29 July 2017

title

The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization (English)

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29 July 2017

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7

V Michael Holers

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29 July 2017

Bärbel Rohrer

1

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29 July 2017

Beth Coughlin

2

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29 July 2017

Kannan Kunchithapautham

3

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29 July 2017

Qin Long

4

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29 July 2017

Stephen Tomlinson

5

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29 July 2017

Kazue Takahashi

6

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29 July 2017

publication date

22 January 2011

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29 July 2017

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29 July 2017

volume

48

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29 July 2017

issue

6-7

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29 July 2017

page(s)

e1-8

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Genetic and therapeutic targeting of properdin in mice prevents complement-mediated tissue injury

29 July 2017

cites work

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Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice.

4 July 2018

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Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis

4 July 2018

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The effect of genetic variants in SERPING1 on the risk of neovascular age-related macular degeneration

4 July 2018

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Microglia in the mouse retina alter the structure and function of retinal pigmented epithelial cells: a potential cellular interaction relevant to AMD.

4 July 2018

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An essential role for RPE-derived soluble VEGF in the maintenance of the choriocapillaris

4 July 2018

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Vascular endothelial growth factor as an autocrine survival factor for retinal pigment epithelial cells under oxidative stress via the VEGF-R2/PI3K/Akt

4 July 2018

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Myocardial ischemia and reperfusion injury is dependent on both IgM and mannose-binding lectin

4 July 2018

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Plasma complement components and activation fragments: associations with age-related macular degeneration genotypes and phenotypes

4 July 2018

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Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury.

4 July 2018

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A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration

4 July 2018

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Evaluation of clustering and genotype distribution for replication in genome wide association studies: the age-related eye disease study

4 July 2018

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Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors

4 July 2018

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Inhibitors of vascular endothelial growth factor (VEGF) in the management of neovascular age-related macular degeneration: a review of current practice.

4 July 2018

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Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

4 July 2018

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Effects of an anti-VEGF-A monoclonal antibody on laser-induced choroidal neovascularization in mice: optimizing methods to quantify vascular changes.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Properdin and complement activation: a fresh perspective

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Multiple, parallel cellular suicide mechanisms participate in photoreceptor cell death

4 July 2018

1 reference

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Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration

4 July 2018

1 reference

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Drusen complement components C3a and C5a promote choroidal neovascularization

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

The central role of the alternative complement pathway in human disease

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

The role of the mannose-binding lectin in innate immunity

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

4 July 2018

1 reference

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Circulating anti-retinal antibodies as immune markers in age-related macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

4 July 2018

1 reference

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Complement factor H polymorphism in age-related macular degeneration

4 July 2018

1 reference

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Complement factor H polymorphism and age-related macular degeneration

4 July 2018

1 reference

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Complement factor H variant increases the risk of age-related macular degeneration

4 July 2018

1 reference

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Mannose-binding lectin-deficient mice display defective apoptotic cell clearance but no autoimmune phenotype

4 July 2018

1 reference

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Photoreceptor synapses degenerate early in experimental choroidal neovascularization

4 July 2018

1 reference

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Decreased thickness and integrity of the macular elastic layer of Bruch's membrane correspond to the distribution of lesions associated with age-related macular degeneration.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

The relative contributions of each subset of ocular infiltrated cells in experimental choroidal neovascularisation

4 July 2018

1 reference

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Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome

4 July 2018

1 reference

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Collections and ficolins: humoral lectins of the innate immune defense

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

A role for local inflammation in the formation of drusen in the aging eye.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Age as an independent risk factor for severity of experimental choroidal neovascularization.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Complement activation and inflammatory processes in Drusen formation and age related macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related macular degeneration

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Host recognition and target differentiation by factor H, a regulator of the alternative pathway of complement

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Abrogation of the alternative complement pathway by targeted deletion of murine factor B

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Evidence for protection against age-related macular degeneration by carotenoids and antioxidant vitamins

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Molecular organization and function of the complement system

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Retinal autoantibody profile in early age-related macular degeneration: preliminary findings from the Blue Mountains Eye Study

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Gastrointestinal ischemia-reperfusion injury is lectin complement pathway dependent without involving C1q.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Structure-function analysis of rods and cones in juvenile, adult, and aged C57bl/6 and Balb/c mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

The role of apoptosis in age-related macular degeneration

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

Pigment epithelium-derived factor is deficient in the vitreous of patients with choroidal neovascularization due to age-related macular degeneration.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3063365

The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation

30 October 2018

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12 December 2020

Long-term ERG analysis in the partially light-damaged mouse retina reveals regressive and compensatory changes

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12 December 2020

Design of a complement mannose-binding lectin pathway-specific activation system applicable at low serum dilutions

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12 December 2020

Mannose-binding lectin binds IgM to activate the lectin complement pathway in vitro and in vivo

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12 December 2020

Pathogenic complement activation in collagen antibody-induced arthritis in mice requires amplification by the alternative pathway

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12 December 2020

C1q-deficiency is neuroprotective against hypoxic-ischemic brain injury in neonatal mice

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12 December 2020

Complement activation pathways in murine immune complex-induced arthritis and in C3a and C5a generation in vitro

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12 December 2020

10.1016/J.MOLIMM.2010.12.016

Identifiers

DOI

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29 July 2017

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29 July 2017

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