Effects of the calcium sensitizer OR-1896, a metabolite of levosimendan, on post-infarct heart failure and cardiac remodelling in diabetic Goto-Kakizaki rats (Q33812788)

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English	Effects of the calcium sensitizer OR-1896, a metabolite of levosimendan, on post-infarct heart failure and cardiac remodelling in diabetic Goto-Kakizaki rats	scientific article

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Effects of the calcium sensitizer OR-1896, a metabolite of levosimendan, on post-infarct heart failure and cardiac remodelling in diabetic Goto-Kakizaki rats (English)

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

author name string

Marjut Louhelainen

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Saara Merasto

2

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Piet Finckenberg

3

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Erik Vahtola

4

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Petri Kaheinen

5

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Jouko Levijoki

6

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Eero Mervaala

7

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

language of work or name

0 references

publication date

1 May 2010

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

British Journal of Pharmacology

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Europe PubMed Central

PubMed publication ID

29 July 2017

160

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Europe PubMed Central

PubMed publication ID

29 July 2017

1

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

142-152

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

Effects of levosimendan on the energy balance: preclinical and clinical evidence

1 reference

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4 July 2018

Cardiac Ca2+ signaling and Ca2+ sensitizers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860214

4 July 2018

Oral levosimendan in patients with severe chronic heart failure --the PERSIST study

1 reference

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4 July 2018

Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency

1 reference

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4 July 2018

Genetic polymorphisms and human aging: association studies deliver

1 reference

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4 July 2018

A role for the RISK pathway and K(ATP) channels in pre- and post-conditioning induced by levosimendan in the isolated guinea pig heart

1 reference

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4 July 2018

NR4A nuclear orphan receptors: protective in vascular disease?

1 reference

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How stem cells age and why this makes us grow old.

1 reference

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4 July 2018

Clinical pharmacology of levosimendan

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860214

4 July 2018

The levosimendan metabolite OR-1896 elicits vasodilation by activating the K(ATP) and BK(Ca) channels in rat isolated arterioles

1 reference

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4 July 2018

The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells.

1 reference

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4 July 2018

The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860214

4 July 2018

Levosimendan: a review of its use in the management of acute decompensated heart failure

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860214

4 July 2018

Vascular endothelial growth factor-regulated gene expression in endothelial cells: KDR-mediated induction of Egr3 and the related nuclear receptors Nur77, Nurr1, and Nor1.

1 reference

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4 July 2018

Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5

1 reference

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4 July 2018

Endothelial dysfunction and salt-sensitive hypertension in spontaneously diabetic Goto-Kakizaki rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860214

4 July 2018

Binding of levosimendan, a calcium sensitizer, to cardiac troponin C.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860214

4 July 2018

E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control

1 reference

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4 July 2018

Troponin C–Mediated Calcium Sensitization Induced by Levosimendan Does Not Impair Relaxation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860214

4 July 2018

Myocardial infarct size and ventricular function in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2860214

4 July 2018

Comparative effects of levosimendan, OR-1896, OR-1855, dobutamine, and milrinone on vascular resistance, indexes of cardiac function, and O2 consumption in dogs

1 reference

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21 January 2018

Molecular analysis of the Ink4a/Rb1-Arf/Tp53 pathways in radon-induced rat lung tumors.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Depressed mitochondrial transcription factors and oxidative capacity in rat failing cardiac and skeletal muscles.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Sustained hemodynamic effects of intravenous levosimendan

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Potassium-specific effects of levosimendan on heart mitochondria

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Improved survival with simendan after experimental myocardial infarction in rats

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Effects of levosimendan on cardiac remodeling and cardiomyocyte apoptosis in hypertensive Dahl/Rapp rats.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Oral levosimendan prevents postinfarct heart failure and cardiac remodeling in diabetic Goto-Kakizaki rats

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Evoked changes in cardiovascular function in rats by infusion of levosimendan, OR-1896 [(R)-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl)acetamide], OR-1855 [(R)-6-(4-aminophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one], dobutamine,

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Effects of OR-1896, a metabolite of levosimendan, on force of contraction and Ca2+ transients under acidotic condition in aequorin-loaded canine ventricular myocardium

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

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Forkhead class O transcription factor 3a activation and Sirtuin1 overexpression in the hypertrophied myocardium of the diabetic Goto-Kakizaki rat.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Cardiac gene expression profile in rats with terminal heart failure and cachexia

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a

1 reference

https://api.crossref.org/works/10.1111%2FJ.1476-5381.2010.00680.X

21 January 2018

Inotropic effects of OR-1896, an active metabolite of levosimendan, on canine ventricular myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cardiomyocyte apoptosis and ventricular remodeling after myocardial infarction in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

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inferred from PubMed ID database lookup

Structural, functional, and molecular characterization of the SHHF model of heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

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inferred from PubMed ID database lookup

Pharmacokinetics of levosimendan in healthy volunteers and patients with congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Levosimendan, a calcium sensitizer in cardiac muscle, induces relaxation in coronary smooth muscle through calcium desensitization

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of potassium channels in relaxant effect of levosimendan in rat small mesenteric arteries

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66 shc Gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of mitochondrial biogenesis by hormesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pathophysiological and genetic characterization of the major diabetes locus in GK rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/20412071

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1476-5381.2010.00680.X

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

29 July 2017

ResearchGate publication ID

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