Cytochrome P450 3A: ontogeny and drug disposition (Q33813327)

29 July 2017

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title

Cytochrome P450 3A: ontogeny and drug disposition (English)

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29 July 2017

2

Kearns GL

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29 July 2017

de Wildt SN

1

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29 July 2017

Leeder JS

series ordinal

3

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29 July 2017

van den Anker JN

series ordinal

4

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29 July 2017

publication date

1 December 1999

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Clinical Pharmacokinetics

29 July 2017

published in

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29 July 2017

volume

37

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29 July 2017

issue

6

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29 July 2017

page(s)

485-505

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Heterogeneity of CYP3A isoforms metabolizing erythromycin and cortisol

29 July 2017

cites work

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12 December 2020

Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test

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12 December 2020

Principles of drug biodisposition in the neonate. A critical evaluation of the pharmacokinetic-pharmacodynamic interface (Part II).

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12 December 2020

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

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12 December 2020

Selective expression of CYP3A5 and not CYP3A4 in human blood

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12 December 2020

Are cytochrome P450 3A enzymes in the small intestine responsible for different cyclosporine metabolite patterns in stable male and female renal allograft recipients after co-administration of diltiazem?

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12 December 2020

Perinatal expression and inducibility of human CYP3A7 in C57BL/6N transgenic mice.

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12 December 2020

Pharmacogenetics in pediatrics. Implications for practice

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12 December 2020

Pharmacokinetics and pharmacodynamics of FK 506 in pediatric patients receiving living-related donor liver transplantations

1 reference

12 December 2020

Steady-state levels and bone marrow toxicity of etoposide in children and infants: does etoposide require age-dependent dose calculation?

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12 December 2020

Steroid hydroxylation by human fetal CYP3A7 and human NADPH-cytochrome P450 reductase coexpressed in insect cells using baculovirus

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12 December 2020

CYP3A gene expression in human gut epithelium

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12 December 2020

Midazolam as an induction agent in children: a pharmacokinetic and clinical study.

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12 December 2020

Immunoquantification of epoxide hydrolase and cytochrome P-450 isozymes in fetal and adult human liver microsomes

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12 December 2020

CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans

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12 December 2020

The increase in urinary excretion of 6 beta-hydroxycortisol as a marker of human hepatic cytochrome P450IIIA induction

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12 December 2020

Association of CYP3A4 genotype with treatment-related leukemia

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12 December 2020

Changes in urinary 6beta-hydroxycortisol/cortisol ratio after birth in human neonates

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12 December 2020

Clinical experience with continuous intravenous sedation using midazolam and fentanyl in the paediatric intensive care unit.

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12 December 2020

Pharmacokinetics and pharmacodynamics of 21-day continuous oral etoposide in pediatric patients with solid tumors*

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12 December 2020

Simultaneous expression of human CYP3A7 and N-acetyltransferase in Chinese hamster CHL cells results in high cytotoxicity for carcinogenic heterocyclic amines.

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12 December 2020

Population pharmacokinetic modeling in very premature infants receiving midazolam during mechanical ventilation: midazolam neonatal pharmacokinetics.

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12 December 2020

Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes

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12 December 2020

Expression of CYP2D6 in developing human liver

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12 December 2020

Carbamazepine: Placental Transport, Tissue Concentrations in Foetus and Newborn, and Level in Milk

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12 December 2020

Biotransformation of caffeine in human liver microsomes from foetuses, neonates, infants and adults

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12 December 2020

Expression of Cytochrome-P450-3A5 in Escherichia Coli: Effects of 5′ Modification, Purification, Spectral Characterization, Reconstitution Conditions, and Catalytic Activities

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12 December 2020

P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature.

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12 December 2020

Molecular and physical mechanisms of first-pass extraction

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12 December 2020

Expression of CYP3A in the Human Liver — Evidence that the Shift between CYP3A7 and CYP3A4 Occurs Immediately After Birth

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12 December 2020

Characterization of microsomal cytochrome P450 enzymes involved in the oxidation of xenobiotic chemicals in human fetal liver and adult lungs.

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12 December 2020

Characterisation of CYP3A gene subfamily expression in human gastrointestinal tissues

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12 December 2020

Pharmacokinetics of tacrolimus (FK 506) in children and adolescents with renal transplants

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12 December 2020

Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of [...]

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12 December 2020

Expression and inducibility of P450 enzymes during liver ontogeny

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12 December 2020

Cyclosporin pharmacokinetics in paediatric transplant recipients

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12 December 2020

High-dose cyclosporin with etoposide--toxicity and pharmacokinetic interaction in children with solid tumours

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12 December 2020

The adverse impact of high cyclosporine. Clearance rates on the incidences of acute rejection and graft loss

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12 December 2020

Urinary excretion of 6 beta-hydroxycortisol as an in vivo marker for CYP3A induction: applications and recommendations

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12 December 2020

Establishment of transgenic mice carrying human fetus-specific CYP3A7.

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12 December 2020

Grapefruit juice-terfenadine single-dose interaction: magnitude, mechanism, and relevance

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12 December 2020

Expression of xenobiotic-metabolizing cytochrome P450 forms in human adult and fetal liver

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12 December 2020

In vitro metabolism of indinavir in the human fetal liver microsomes.

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12 December 2020

A size standard for pharmacokinetics.

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12 December 2020

The pharmacokinetics of midazolam in man.

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12 December 2020

Decreased intestinal CYP3A in celiac disease: Reversal after successful gluten-free diet: A potential source of interindividual variability in first-pass drug metabolism*

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12 December 2020

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

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12 December 2020

Identification of the fetal liver cytochrome CYP3A7 in human endometrium and placenta

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12 December 2020

Induction of mixed function oxidase activity in man by rifapentine (MDL 473), a long-acting rifamycin derivative

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12 December 2020

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine

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12 December 2020

Bimodal distribution of renal cytochrome P450 3A activity in humans.

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12 December 2020

Characterization of cytochrome P450 expression in human oesophageal mucosa.

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12 December 2020

Cyclosporin toxicity at therapeutic blood levels and cytochrome P-450 IIIA.

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12 December 2020

Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

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12 December 2020

Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

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12 December 2020

Clinical importance of non-genetic and genetic cytochrome P450 function tests in liver disease

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12 December 2020

CYP 3A proteins are expressed in human neutrophils and lymphocytes but are not induced by rifampicin

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12 December 2020

The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver.

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12 December 2020

Cytochrome P450 3A proteins are expressed in B lymphocytes but not in T lymphocytes

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12 December 2020

Selective expression of cytochrome P450 CYP3A mRNAs in embryonic and adult human liver

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12 December 2020

Astemizole-induced cardiac conduction disturbances in a child

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12 December 2020

Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

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12 December 2020

Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary culture

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12 December 2020

Pharmacokinetic interactions between antiepileptic drugs. Clinical considerations

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12 December 2020

Interactions of phenobarbital and phenytoin with carbamazepine and its metabolites' concentrations, concentration ratios, and level/dose ratios in epileptic children

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12 December 2020

Intralobular distribution and quantitation of cytochrome P-450 enzymes in human liver as a function of age

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12 December 2020

Use of midazolam as a human cytochrome P450 3A probe: II. Characterization of inter- and intraindividual hepatic CYP3A variability after liver transplantation.

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12 December 2020

Drug interactions and interindividual variability of ciclosporin metabolism in the small intestine

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12 December 2020

Population pharmacokinetics of midazolam in neonates.

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12 December 2020

The metabolization of carbamazepine to CBZ-10,11-epoxide in children from the newborn age to adolescence

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12 December 2020

Comparison of urinary 6beta-hydroxycortisol/cortisol ratio between neonates and their mothers

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12 December 2020

Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.

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12 December 2020

A comparison of hepatic cytochrome P450 protein expression between infancy and postinfancy

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12 December 2020

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

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12 December 2020

Midazolam: pharmacology and uses

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12 December 2020

Onset of xenobiotic metabolism in children: toxicological implications

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12 December 2020

The human hepatic cytochromes P450 involved in drug metabolism

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12 December 2020

Assignment of the human cytochrome P-450 nifedipine oxidase gene (CYP3A4) to chromosome 7 at band q22.1 by fluorescence in situ hybridization

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12 December 2020

A pharmacokinetic study of midazolam in paediatric patients undergoing cardiac surgery.

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12 December 2020

First-pass metabolism of midazolam by the human intestine.

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12 December 2020

Midazolam. A review of its pharmacological properties and therapeutic use.

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12 December 2020

Primary human hepatocytes as a tool for the evaluation of structure-activity relationship in cytochrome P450 induction potential of xenobiotics: evaluation of rifampin, rifapentine and rifabutin

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12 December 2020

Sequences of intestinal and hepatic cytochrome P450 3A4 cDNAs are identical

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12 December 2020

The use of other drugs to allow a lower dosage of cyclosporin to be used. Therapeutic and pharmacoeconomic considerations

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12 December 2020

A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes.

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12 December 2020

Induction of drug metabolizing enzyme activities in the human fetus and in the newborn infant

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12 December 2020

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism

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12 December 2020

Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation

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12 December 2020

Effects of cisapride on QTc interval in neonates

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12 December 2020

Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation

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12 December 2020

Cytochrome P 450 isoenzymes, epoxide hydrolase and glutathione transferases in rat and human hepatic and extrahepatic tissues

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12 December 2020

Cisapride high dosage and long QT interval

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12 December 2020

Steady-state plasma concentrations of midazolam in critically ill infants and children.

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12 December 2020

Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes

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12 December 2020

Carbamazepine age-dose ratio relationship in children

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12 December 2020

Haemodynamic responses and population pharmacokinetics of midazolam following administration to ventilated, preterm neonates.

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12 December 2020

No ethnic difference between Caucasian and Japanese hepatic samples in the expression frequency of CYP3A5 and CYP3A7 proteins

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12 December 2020

Cytochrome P450 CYP3A5 in the human anterior pituitary gland

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12 December 2020

The human drug metabolizing cytochromes P450.

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12 December 2020

Comparison of urinary 6-beta-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

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12 December 2020

Acetaminophen: Potentially Toxic Metabolite Formed by Human Fetal and Adult Liver Microsomes and Isolated Fetal Liver Cells

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12 December 2020

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

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12 December 2020

Pharmacokinetics of midazolam during continuous infusion in critically ill neonates

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12 December 2020

Placebo-controlled trial of midazolam sedation in mechanically ventilated newborn babies.

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12 December 2020

Pharmacokinetics of midazolam in critically ill neonates.

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12 December 2020

Identification of a novel dexamethasone responsive enhancer in the human CYP3A5 gene and its activation in human and rat liver cells

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12 December 2020

Pharmacokinetic interaction between ritonavir and clarithromycin

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12 December 2020

The area under the plasma concentration-time curve for oral midazolam is 400-fold larger during treatment with itraconazole than with rifampicin.

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12 December 2020

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice

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12 December 2020

Identification of a polymorphically expressed member of the human cytochrome P-450III family

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12 December 2020

Purification and properties of cytochrome P-450 from homogenates of human fetal livers

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12 December 2020

FK 506 in liver transplantation: correlation of whole blood levels with efficacy and toxicity. The US Multicenter FK 506 Dose Optimization

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12 December 2020

Developmental expression of cytochrome P450 enzymes in human liver

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12 December 2020

Lidocaine metabolism in human liver microsomes by cytochrome P450IIIA4.

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12 December 2020

Cyclosporine dosage according to pharmacokinetic profiles leads to better graft and patient survival rates and a decrease in cyclosporine consumption

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12 December 2020

Delayed ontogenesis of CYP1A2 in the human liver

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12 December 2020

Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450

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12 December 2020

Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam

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12 December 2020

Functional cytochrome P4503A isoforms in human embryonic tissues: expression during organogenesis.

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12 December 2020

Separate and interactive regulation of cytochrome P450 3A4 by triiodothyronine, dexamethasone, and growth hormone in cultured hepatocytes

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12 December 2020

Inhibition of cytochrome P-450 3A (CYP3A) in human intestinal and liver microsomes: comparison of Ki values and impact of CYP3A5 expression.

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12 December 2020

The erythromycin breath test selectively measures P450IIIA in patients with severe liver disease

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12 December 2020

Plasma concentrations and effects of oral methylprednisolone are considerably increased by itraconazole

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12 December 2020

Accidental astemizole overdose in young children

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12 December 2020

Absence of CYP3A genetic polymorphism assessed by urinary excretion of 6 beta-hydroxycortisol in 102 healthy subjects on rifampicin

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12 December 2020

Cyclosporin clinical pharmacokinetics

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12 December 2020

The pharmacokinetics of midazolam in paediatric patients.

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12 December 2020

Fetus-specific CYP3A7 and adult-specific CYP3A4 expressed in Chinese hamster CHL cells have similar capacity to activate carcinogenic mycotoxins

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12 December 2020

Human fetal and adult liver metabolism of ethylmorphine. Relation to immunodetected cytochrome P-450 PCN and interactions with important fetal corticosteroids.

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12 December 2020

Clinical pharmacokinetics in newborns and infants. Age-related differences and therapeutic implications

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12 December 2020

Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism.

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12 December 2020

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver

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12 December 2020

Drug metabolizing enzymes related to laboratory medicine: cytochromes P-450 and UDP-glucuronosyltransferases.

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12 December 2020

Significance of cytochrome P-450 (P-450 HFLa) of human fetal livers in the steroid and drug oxidations

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12 December 2020

Studies on the expression and metabolic capabilities of human liver cytochrome P450IIIA5 (HLp3)

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12 December 2020

The fetal specific gene CYP3A7 is inducible by rifampicin in adult human hepatocytes in primary culture.

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12 December 2020

Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture

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12 December 2020

Evidence for pre-hepatic metabolism of oral cyclosporine in children

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12 December 2020

Erythromycin breath test predicts oral clearance of cyclosporine in kidney transplant recipients

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12 December 2020

Pharmacogenetics and development: are infants and children at increased risk for adverse outcomes?

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12 December 2020

Interindividual variability in catalytic activity and immunoreactivity of three major human liver cytochrome P450 isozymes

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12 December 2020

Cardiotoxic effects of astemizole overdose in children

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12 December 2020

Screening for cytochrome P450 3A in man: studies with midazolam and nifedipine.

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12 December 2020

Noninvasive tests of CYP3A enzymes

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12 December 2020

Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.

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12 December 2020

Unconsciousness associated with midazolam and erythromycin

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12 December 2020

Expression of CYP3A4, CYP3A5 and CYP3A7 in human duodenal tissue

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12 December 2020

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients

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12 December 2020

Formation of carbamazepine epoxide in human fetal liver

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12 December 2020

Pharmacokinetics and pharmacodynamics of nifedipine in children with bronchopulmonary dysplasia and pulmonary hypertension.

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12 December 2020

Update: clinically significant cytochrome P-450 drug interactions

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12 December 2020

Differential catalytic properties in metabolism of endogenous and exogenous substrates among CYP3A enzymes expressed in COS-7 cells

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12 December 2020

Liver volume as a determinant of drug clearance in children and adolescents

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12 December 2020

Cytochrome P-450 expression in sudden infant death syndrome

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12 December 2020

Non invasive in vivo study of the maturation of CYP IIIA in neonates and infants

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12 December 2020

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

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12 December 2020

Disposition of placentally transferred carbamazepine (Tegretol�) in the newborn

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12 December 2020

Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7

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12 December 2020

P-450 HFLa, a form of cytochrome P-450 purified from human fetal livers, is the 16 alpha-hydroxylase of dehydroepiandrosterone 3-sulfate

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12 December 2020

Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man

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12 December 2020

10.2165/00003088-199937060-00004

Identifiers

DOI

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Dimensions Publication ID

29 July 2017

1023778408

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