Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system (Q33829619)

29 July 2017

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title

Polyploidy: occurrence in nature, mechanisms, and significance for the megakaryocyte-platelet system (English)

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29 July 2017

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Zimmet J

1

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29 July 2017

Ravid K

series ordinal

2

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29 July 2017

publication date

1 January 2000

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29 July 2017

published in

Experimental Hematology

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29 July 2017

volume

28

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29 July 2017

issue

1

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29 July 2017

page(s)

3-16

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Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles

29 July 2017

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Abnormal cellular DNA content as a marker of neoplasia

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7 January 2021

Prognostic significance of DNA ploidy in patients with stage II and stage III colon carcinoma: a prospective flow cytometric study

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7 January 2021

DNA flow cytometric analysis and prognosis of axillary lymph node-negative breast carcinoma

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7 January 2021

Correlation of DNA ploidy and histologic diagnosis from prostate core-needle biopsies: is DNA ploidy more sensitive than histology for the diagnosis of carcinoma in small specimens?

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Mechanisms restricting DNA replication to once per cell cycle: MCMS, pre-replicative complexes and kinases

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7 January 2021

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

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7 January 2021

The nuclear membrane prevents replication of human G2 nuclei but not G1 nuclei in Xenopus egg extract

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7 January 2021

A role for the nuclear envelope in controlling DNA replication within the cell cycle

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7 January 2021

The role of MCM proteins in the cell cycle control of genome duplication

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7 January 2021

The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts

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7 January 2021

Licensing of DNA replication by a multi-protein complex of MCM/P1 proteins in Xenopus eggs

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7 January 2021

DNA polymerase alpha associated protein P1, a murine homolog of yeast MCM3, changes its intranuclear distribution during the DNA synthetic period.

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7 January 2021

Cell cycle regulation of the replication licensing system: involvement of a Cdk-dependent inhibitor

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7 January 2021

Ordering S phase and M phase in the cell cycle

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7 January 2021

G1 phase progression: cycling on cue

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7 January 2021

Cyclins and their associated cyclin-dependent kinases in the human cell cycle

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7 January 2021

Cyclin a is required for the onset of DNA replication in mammalian fibroblasts

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7 January 2021

Cyclin A is required at two points in the human cell cycle

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7 January 2021

Association of human cyclin E with a periodic G1-S phase protein kinase

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7 January 2021

Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycle

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7 January 2021

Identification of G1 kinase activity for cdk6, a novel cyclin D partner

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7 January 2021

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

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7 January 2021

D type cyclins associate with multiple protein kinases and the DNA replication and repair factor PCNA

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7 January 2021

Cdc2 regulatory factors

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7 January 2021

Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15.

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

p21 inhibits cyclin shock

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7 January 2021

Feedback control of mitosis in budding yeast

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7 January 2021

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function

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7 January 2021

Identification of a human mitotic checkpoint gene: hsMAD2

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7 January 2021

Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage

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7 January 2021

Fission yeast Slp1: an effector of the Mad2-dependent spindle checkpoint

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7 January 2021

Budding yeast Cdc20: a target of the spindle checkpoint.

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7 January 2021

A p53-dependent mouse spindle checkpoint

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7 January 2021

Characterization of the p53-dependent postmitotic checkpoint following spindle disruption

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7 January 2021

Uncoupled cell cycle without mitosis induced by a protein kinase inhibitor, K-252a

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7 January 2021

A protein kinase-dependent block to reinitiation of DNA replication in G2 phase in mammalian cells

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7 January 2021

Reprogramming the cell cycle for endoreduplication in rodent trophoblast cells

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7 January 2021

Chromatid segregation at anaphase requires the barren product, a novel chromosome-associated protein that interacts with Topoisomerase II.

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7 January 2021

Block in anaphase chromosome separation caused by a telomerase template mutation.

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7 January 2021

Bypassing anaphase by fission yeast cut9 mutation: requirement of cut9+ to initiate anaphase

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7 January 2021

Plk is an M-phase-specific protein kinase and interacts with a kinesin-like protein, CHO1/MKLP-1

1 reference

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7 January 2021

Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

A cytokinesis checkpoint requiring the yeast homologue of an APC-binding protein.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Rng2p, a protein required for cytokinesis in fission yeast, is a component of the actomyosin ring and the spindle pole body

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Defect in cytokinesis of fission yeast induced by mutation in the WD40 repeat motif of a TFIID subunit

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Megakaryocytopoiesis in the human fetus

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Analysis of megakaryocyte ploidy in fetal bone marrow biopsies using a new adaptation of the feulgen technique to measure DNA content and estimate megakaryocyte ploidy from biopsy specimens

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor Mpl.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

cMpl ligand is a humoral regulator of megakaryocytopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Thrombocytopenia in c-mpl-deficient mice

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

The cell cycle in polyploid megakaryocytes is associated with reduced activity of cyclin B1-dependent cdc2 kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Significance of polyploidy in megakaryocytes and other cells in health and tumor disease

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Novel alterations in CDK1/cyclin B1 kinase complex formation occur during the acquisition of a polyploid DNA content

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Ubiquitin-dependent degradation of cyclin B is accelerated in polyploid megakaryocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

TPR proteins required for anaphase progression mediate ubiquitination of mitotic B-type cyclins in yeast

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

A role for cyclin D3 in the endomitotic cell cycle

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Megakaryocytes in states of altered platelet production: cell numbers, size and DNA content

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Megakaryocytes and the heterogeneity of circulating platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

The relation of megakaryocyte ploidy to platelet volume

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Ultrastructural analysis of acute immune thrombocytopenia in mice: dissociation between alterations in megakaryocytes and platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Prediction of haemorrhagic diathesis in thrombocytopenia by mean platelet volume

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

The biological significance of platelet volume: its relationship to bleeding time, platelet thromboxane B2 production and megakaryocyte nuclear DNA concentration

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Arachidonic acid metabolism by platelets of differing size

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Depression of the Megakaryocyte-Platelet System in Rats by Transfusion of Platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Regulation of thrombopoiesis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Evidence that stimulation of megakaryocytopoiesis by low dose vincristine results from an effect on platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

The effects of low-dose vincristine on megakaryocyte colony-forming cells and megakaryocyte ploidy

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7 January 2021

Disruption of microtubules in vivo by vincristine induces large membrane complexes and other cytoplasmic abnormalities in megakaryocytes and platelets of normal rats like those in human and Wistar Furth rat hereditary macrothrombocytopenias

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Megakaryocyte Quantifications in Relation to Thrombokinetics in Primary Thrombocythaemia and Allied Diseases

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Megakaryocytes and platelets in myeloproliferative disorders

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Flow cytometric analysis of megakaryocyte ploidy in chronic myeloproliferative disorders and reactive thrombocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Analysis of megakaryocyte ploidy in patients with thrombocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Megakaryocyte polyploidy and maturation in chronic granulocytic leukemia

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Overexpression of granulocyte colony-stimulating factor in vivo decreases the level of polyploidization of mouse bone marrow megakaryocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Dual-color flow cytometric analysis of megakaryocytic DNA ploidy in the investigation of blastic phase chronic myelogenous leukemia with rearrangement of 3q26

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Review of the cytogenetic changes in acute megakaryoblastic leukemia: one disease or several?

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7 January 2021

Acute Megakaryoblastic Leukemia

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7 January 2021

Megakaryocyte ploidy and platelet changes in human diabetes and atherosclerosis

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Accelerated atherogenesis occurs following platelet destruction and increases in megakaryocyte size and DNA content

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

The effect of hypercholesterolemia on guinea pig platelets, erythrocytes and megakaryocytes

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Platelet and megakaryocyte changes in cholesterol-induced experimental atherosclerosis

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Megakaryocyte and vascular changes in rabbits on a short-term high cholesterol diet

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

The megakaryocyte platelet system and vascular disease

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Ploidy regulation of gene expression

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Regulation of thrombopoietin levels by c-mpl-mediated binding to platelets

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

Thrombopoietin: the primary regulator of platelet production [see comments]

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https://api.crossref.org/works/10.1016%2FS0301-472X%2899%2900124-1

7 January 2021

10.1016/S0301-472X(99)00124-1

Identifiers

DOI

1 reference

29 July 2017

1 reference