Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents (Q33833531)

29 July 2017

title

Macrocyclic pyridyl polyoxazoles: selective RNA and DNA G-quadruplex ligands as antitumor agents (English)

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29 July 2017

Suzanne G Rzuczek

1

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29 July 2017

Daniel S Pilch

2

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29 July 2017

Angela Liu

3

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29 July 2017

Leroy Liu

4

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29 July 2017

Edmond J LaVoie

5

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29 July 2017

Joseph E Rice

6

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29 July 2017

language of work or name

English

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publication date

1 May 2010

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Journal of Medicinal Chemistry

29 July 2017

published in

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29 July 2017

volume

53

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29 July 2017

issue

9

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29 July 2017

page(s)

3632-3644

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DNA loop sequence as the determinant for chiral supramolecular compound G-quadruplex selectivity

29 July 2017

cites work

1 reference

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A G-quadruplex stabilizer induces M-phase cell cycle arrest

4 July 2018

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Chiral metallo-supramolecular complexes selectively recognize human telomeric G-quadruplex DNA.

4 July 2018

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Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency

4 July 2018

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Targeting human telomeric G-quadruplex DNA with oxazole-containing macrocyclic compounds.

4 July 2018

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Lysinyl macrocyclic hexaoxazoles: synthesis and selective G-quadruplex stabilizing properties

4 July 2018

1 reference

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Defining the mode, energetics and specificity with which a macrocyclic hexaoxazole binds to human telomeric G-quadruplex DNA

4 July 2018

1 reference

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Beta-aminoethyltrifluoroborates: efficient aminoethylations via Suzuki-Miyaura cross-coupling

4 July 2018

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Structure of the human telomere in K+ solution: an intramolecular (3 + 1) G-quadruplex scaffold

4 July 2018

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Binding of G-quadruplex-interactive agents to distinct G-quadruplexes induces different biological effects in MiaPaCa cells

4 July 2018

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Telomerase inhibition, telomere shortening, cell growth suppression and induction of apoptosis by telomestatin in childhood neuroblastoma cells

4 July 2018

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Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug.

4 July 2018

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DNA tetraplex-binding drugs: structure-selective targeting is critical for antitumour telomerase inhibition

4 July 2018

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G-quadruplexes as therapeutic targets

4 July 2018

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Telomestatin, a novel telomerase inhibitor from Streptomyces anulatus

4 July 2018

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Ethidium derivatives bind to G-quartets, inhibit telomerase and act as fluorescent probes for quadruplexes

4 July 2018

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G-quadruplex DNA: a potential target for anti-cancer drug design

4 July 2018

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G-quadruplexes as targets for drug design

4 July 2018

1 reference

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NMR-Based model of a telomerase-inhibiting compound bound to G-quadruplex DNA.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865558

Statistical thermodynamics of nucleic acid melting transitions with coupled binding equilibria

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865558

Characterization of a mammalian mutant with a camptothecin-resistant DNA topoisomerase I.

4 July 2018

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Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy

4 July 2018

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Theoretical calculations of the helix-coil transition of DNA in the presence of large, cooperatively binding ligands

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865558

Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles.

4 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865558

G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865558

Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular g-quadruplex

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2865558

Design and synthesis of fluoroquinophenoxazines that interact with human telomeric G-quadruplexes and their biological effects

29 October 2018

1 reference

12 December 2020

Inhibition of human telomerase by a G-quadruplex-interactive compound

1 reference

12 December 2020

Human telomerase inhibition by substituted acridine derivatives

1 reference

12 December 2020

Telomerase inhibition with a novel G-quadruplex-interactive agent, telomestatin: in vitro and in vivo studies in acute leukemia

1 reference

12 December 2020

Scope of the Suzuki-Miyaura aminoethylation reaction using organotrifluoroborates

1 reference

12 December 2020

Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor

1 reference

12 December 2020

Identifiers

DOI

10.1021/JM1000612

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29 July 2017

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29 July 2017

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