Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors (Q33844595)

29 July 2017

title

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors (English)

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14

Benjamin F Cravatt

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Chu Wang

4

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author name string

Daniel A Bachovchin

1

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Justin T Mohr

2

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Anna E Speers

3

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Jacob M Berlin

5

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Timothy P Spicer

6

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Virneliz Fernandez-Vega

7

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Peter Chase

8

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Peter S Hodder

9

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Stephan C Schürer

10

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Daniel K Nomura

11

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Hugh Rosen

12

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Gregory C Fu

13

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language of work or name

English

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publication date

11 March 2011

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Proceedings of the National Academy of Sciences of the United States of America

29 July 2017

published in

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volume

108

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issue

17

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page(s)

6811-6816

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Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

29 July 2017

cites work

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Regulation of protein phosphatase 2A methylation by LCMT1 and PME-1 plays a critical role in differentiation of neuroblastoma cells

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Acylating drugs: redesigning natural covalent inhibitors

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Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

5 July 2018

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PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma

5 July 2018

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Targeted disruption of the PME-1 gene causes loss of demethylated PP2A and perinatal lethality in mice

5 July 2018

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5 July 2018

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5 July 2018

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A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

5 July 2018

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5 July 2018

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Assessing enzyme activities using stable isotope labeling and mass spectrometry

5 July 2018

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Profiling enzyme activities in vivo using click chemistry methods

5 July 2018

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An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator

5 July 2018

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Structure of protein phosphatase methyltransferase 1 (PPM1), a leucine carboxyl methyltransferase involved in the regulation of protein phosphatase 2A activity

5 July 2018

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Discovering potent and selective reversible inhibitors of enzymes in complex proteomes

5 July 2018

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5 July 2018

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Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

5 July 2018

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Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits

5 July 2018

1 reference

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Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo

5 July 2018

1 reference

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Activity-based protein profiling: the serine hydrolases

5 July 2018

1 reference

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A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A

5 July 2018

1 reference

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Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit

5 July 2018

1 reference

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Physiologic importance of protein phosphatase inhibitors

5 July 2018

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Protein phosphatase methyltransferase 1 (Ppm1p) is the sole activity responsible for modification of the major forms of protein phosphatase 2A in yeast

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1015248108

Direct visualization of serine hydrolase activities in complex proteomes using fluorescent active site-directed probes

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1015248108

Functional and quantitative proteomics using SILAC

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.1015248108

21 January 2018

Identifiers

DOI

10.1073/PNAS.1015248108

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29 July 2017

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29 July 2017

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