Design of novel sequence-specific DNA-binding proteins (Q33840380)

29 July 2017

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title

Design of novel sequence-specific DNA-binding proteins (English)

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29 July 2017

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Segal DJ

1

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29 July 2017

Barbas CF 3rd

series ordinal

2

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29 July 2017

publication date

1 February 2000

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Current Opinion in Chemical Biology

29 July 2017

published in

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29 July 2017

volume

4

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29 July 2017

issue

1

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29 July 2017

page(s)

34-39

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Towards the design of rare cutting restriction endonucleases: using directed evolution to generate variants of EcoRV differing in their substrate specificity by two orders of magnitude

29 July 2017

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The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex

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7 January 2021

In vivo selection of basic region-leucine zipper proteins with altered DNA-binding specificities

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7 January 2021

The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements

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7 January 2021

Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA

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7 January 2021

Analysis of estrogen response element binding by genetically selected steroid receptor DNA binding domain mutants exhibiting altered specificity and enhanced affinity.

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7 January 2021

Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices

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7 January 2021

Differences between plant and animal Myb domains are fundamental for DNA binding activity, and chimeric Myb domains have novel DNA binding specificities

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7 January 2021

Construction of an artificial tandem protein of the c-Myb DNA-binding domain and analysis of its DNA binding specificity

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7 January 2021

Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

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7 January 2021

Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5'-GNN-3' DNA target sequences

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7 January 2021

Selection of DNA binding sites for zinc fingers using rationally randomized DNA reveals coded interactions

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7 January 2021

Use of a zinc-finger consensus sequence framework and specificity rules to design specific DNA binding proteins

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7 January 2021

Binding properties of the artificial zinc fingers coding gene Sint1

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7 January 2021

Analysis of zinc fingers optimized via phage display: evaluating the utility of a recognition code

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7 January 2021

Synergy between adjacent zinc fingers in sequence-specific DNA recognition

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7 January 2021

Comprehensive DNA recognition through concerted interactions from adjacent zinc fingers

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7 January 2021

A zinc finger directory for high-affinity DNA recognition

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7 January 2021

A general strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites

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7 January 2021

Toward controlling gene expression at will: specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks

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7 January 2021

Transcriptional repression by zinc finger peptides. Exploring the potential for applications in gene therapy

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7 January 2021

High-resolution structures of variant Zif268-DNA complexes: implications for understanding zinc finger-DNA recognition

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7 January 2021

Differing roles for zinc fingers in DNA recognition: structure of a six-finger transcription factor IIIA complex

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7 January 2021

Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity

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7 January 2021

The role of zinc finger linkers in p43 and TFIIIA binding to 5S rRNA and DNA.

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7 January 2021

Design of polydactyl zinc-finger proteins for unique addressing within complex genomes

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7 January 2021

Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants.

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7 January 2021

Genetic selection of short peptides that support protein oligomerization in vivo

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7 January 2021

Targeting a truncated Ho-endonuclease of yeast to novel DNA sites with foreign zinc fingers

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7 January 2021

Chimeric restriction enzymes: what is next?

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7 January 2021

Cytosine methylation targetted to pre-determined sequences

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7 January 2021

Positive and negative regulation of endogenous genes by designed transcription factors

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7 January 2021

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Identifiers

DOI

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29 July 2017

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