Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase (Q33890035)

29 July 2017

title

Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase (English)

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ribosomal protein S6 kinase activity

29 July 2017

main subject

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Gene Ontology release 2020-05-02

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Shima H

1

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29 July 2017

Pende M

2

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29 July 2017

Chen Y

3

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29 July 2017

Fumagalli S

4

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29 July 2017

Thomas G

5

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29 July 2017

Kozma SC

6

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29 July 2017

language of work or name

English

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publication date

1 November 1998

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full work available at URL

29 July 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1171010

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published in

The EMBO Journal

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29 July 2017

volume

17

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29 July 2017

issue

22

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29 July 2017

page(s)

6649-6659

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A rapid purification protocol for the mitogen-activated p70 S6 kinase

29 July 2017

cites work

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

5 July 2018

1 reference

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Translation control: connecting mitogens and the ribosome

5 July 2018

1 reference

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Disruption of IRS-2 causes type 2 diabetes in mice

5 July 2018

1 reference

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Phosphorylation and activation of p70s6k by PDK1

5 July 2018

1 reference

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Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

5 July 2018

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Dual requirement for a newly identified phosphorylation site in p70s6k

5 July 2018

1 reference

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The insulin-induced signalling pathway leading to S6 and initiation factor 4E binding protein 1 phosphorylation bifurcates at a rapamycin-sensitive point immediately upstream of p70s6k

5 July 2018

1 reference

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The modular phosphorylation and activation of p70s6k.

5 July 2018

1 reference

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Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

MLP-deficient mice exhibit a disruption of cardiac cytoarchitectural organization, dilated cardiomyopathy, and heart failure

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Germ line chimeras from female ES cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

5 July 2018

1 reference

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5 July 2018

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The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases

5 July 2018

1 reference

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The Drosophila p70s6k homolog exhibits conserved regulatory elements and rapamycin sensitivity

5 July 2018

1 reference

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The role of the genome project in determining gene function: insights from model organisms

5 July 2018

1 reference

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The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression

5 July 2018

1 reference

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The 70 kDa S6 kinase: regulation of a kinase with multiple roles in mitogenic signalling

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Simple and efficient production of embryonic stem cell-embryo chimeras by coculture

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

dbEST--database for "expressed sequence tags"

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Elongation factor-1 alpha mRNA is selectively translated following mitogenic stimulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Attenuation of ribosomal protein S6 phosphatase activity in chicken embryo fibroblasts transformed by Rous sarcoma virus.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Nuclear localization of p85s6k: functional requirement for entry into S phase.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Activation of p70/p85 S6 kinase by a pathway independent of p21ras

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Multiple independent inputs are required for activation of the p70 S6 kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

The v-Src SH3 Domain Binds Phosphatidylinositol 3'-Kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

The principal target of rapamycin-induced p70s6k inactivation is a novel phosphorylation site within a conserved hydrophobic domain.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Identification and characterization of a mitogen-activated S6 kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Purification and characterization of a 40 S ribosomal protein S6 kinase from vanadate-stimulated Swiss 3T3 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Differential regulation of S6 phosphorylation by insulin and epidermal growth factor in Swiss mouse 3T3 cells: insulin activation of type 1 phosphatase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

A stimulated S6 kinase from rat liver: identity with the mitogen activated S6 kinase of 3T3 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Altering the genome by homologous recombination

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Purification and properties of mitogen-activated S6 kinase from rat liver and 3T3 cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Cloning of the mitogen-activated S6 kinase from rat liver reveals an enzyme of the second messenger subfamily

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Activation of p70s6k is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1171010

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

5 July 2018

1 reference

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Identification and early activation of a Xenopus laevis p70s6k following progesterone-induced meiotic maturation

5 July 2018

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5 July 2018

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TOR signalling and control of cell growth

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Lipid-Regulated Kinases: Some Common Themes at Last

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Phosphorylation of ribosomal protein S6. Relationship to protein synthesis in HeLa cells

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p70s6k function is essential for G1 progression

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The effect of rapamycin on T cell development in mice

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Identifiers

DOI

10.1093/EMBOJ/17.22.6649

1 reference

29 July 2017

1 reference

29 July 2017

1 reference