Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro (Q33908885)

29 July 2017

title

Hypoxia modulates EWS-FLI1 transcriptional signature and enhances the malignant properties of Ewing's sarcoma cells in vitro (English)

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29 July 2017

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11

Christopher Poremba

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29 July 2017

Heinrich Kovar

13

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author name string

Dave N T Aryee

1

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29 July 2017

Stephan Niedan

2

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29 July 2017

Maximilian Kauer

3

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29 July 2017

Raphaela Schwentner

4

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29 July 2017

Idriss M Bennani-Baiti

5

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29 July 2017

Jozef Ban

6

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29 July 2017

Karin Muehlbacher

7

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29 July 2017

Michael Kreppel

8

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29 July 2017

Robert L Walker

9

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29 July 2017

Paul Meltzer

10

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29 July 2017

Reinhard Kofler

12

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29 July 2017

language of work or name

English

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publication date

4 May 2010

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29 July 2017

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29 July 2017

volume

70

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29 July 2017

issue

10

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29 July 2017

page(s)

4015-4023

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A molecular function map of Ewing's sarcoma

29 July 2017

cites work

1 reference

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The oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation function

5 July 2018

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GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.

5 July 2018

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Monocytes and dendritic cells in a hypoxic environment: Spotlights on chemotaxis and migration

5 July 2018

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Genetically defined EWS/FLI1 model system suggests mesenchymal origin of Ewing's family tumors

5 July 2018

1 reference

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Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death

5 July 2018

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Regulation of gene expression by hypoxia.

5 July 2018

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IGF1 is a common target gene of Ewing's sarcoma fusion proteins in mesenchymal progenitor cells.

5 July 2018

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5 July 2018

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A transcriptional profiling meta-analysis reveals a core EWS-FLI gene expression signature

5 July 2018

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Hypoxia and the presence of human vascular endothelial cells affect prostate cancer cell invasion and metabolism.

5 July 2018

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Hypoxia-driven selection of the metastatic phenotype

5 July 2018

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Effects of hypoxia on tumor metabolism

5 July 2018

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Single-chain antibodies to the EWS NH(2) terminus structurally discriminate between intact and chimeric EWS in Ewing's sarcoma and interfere with the transcriptional activity of EWS in vivo

5 July 2018

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Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma.

5 July 2018

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Ewing's sarcoma oncoprotein EWS-FLI1: the perfect target without a therapeutic agent

5 July 2018

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Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles

5 July 2018

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PAGE: parametric analysis of gene set enrichment

5 July 2018

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Context matters: the hen or egg problem in Ewing's sarcoma.

5 July 2018

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DNA microarrays reveal relationship of Ewing family tumors to both endothelial and fetal neural crest-derived cells and define novel targets

5 July 2018

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5 July 2018

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The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis

5 July 2018

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O2-regulated gene expression: transcriptional control of cardiorespiratory physiology by HIF-1.

5 July 2018

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Potentials for RNAi in sarcoma research and therapy: Ewing's sarcoma as a model.

5 July 2018

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Targeting HIF-1 for cancer therapy

5 July 2018

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Investigating hypoxic tumor physiology through gene expression patterns

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes

5 July 2018

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Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells

5 July 2018

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Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly

5 July 2018

1 reference

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The Ewing's sarcoma oncoprotein EWS/FLI induces a p53-dependent growth arrest in primary human fibroblasts

5 July 2018

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HIF-1 and tumor progression: pathophysiology and therapeutics

5 July 2018

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Hypoxia--a key regulatory factor in tumour growth

5 July 2018

1 reference

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Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

Hypoxia inducible factor (HIF-1a and HIF-2a) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy

5 July 2018

1 reference

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Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases

5 July 2018

1 reference

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Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

EWS/FLI function varies in different cellular backgrounds.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

Anchorage-independent multi-cellular spheroids as an in vitro model of growth signaling in Ewing tumors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2884367

Increased expression of hypoxia inducible factor-1alpha in rat and human prostate cancer

29 October 2018

1 reference

12 December 2020

The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α

1 reference

12 December 2020

Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer

1 reference

12 December 2020

Hyperinducibility of hypoxia-responsive genes without p53/p21-dependent checkpoint in aggressive prostate cancer

1 reference

12 December 2020

10.1158/0008-5472.CAN-09-4333

Identifiers

DOI

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29 July 2017

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29 July 2017

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