Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease (Q33908944)

29 July 2017

title

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease (English)

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29 July 2017

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Chen M

1

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Ona VO

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Li M

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Ferrante RJ

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Fink KB

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Zhu S

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Bian J

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Guo L

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Farrell LA

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Hersch SM

10

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Hobbs W

11

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Vonsattel JP

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Cha JH

13

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Friedlander RM

14

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language of work or name

English

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publication date

1 July 2000

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volume

6

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issue

7

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page(s)

797-801

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

29 July 2017

cites work

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7 January 2021

Human ICE/CED-3 protease nomenclature

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7 January 2021

ICE, neuronal apoptosis and neurodegeneration

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7 January 2021

Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease

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7 January 2021

Cleavage of huntingtin by apopain, a proapoptotic cysteine protease, is modulated by the polyglutamine tract

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7 January 2021

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

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7 January 2021

Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia

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7 January 2021

A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic window

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7 January 2021

Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse

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7 January 2021

Biochemical abnormalities and excitotoxicity in Huntington's disease brain.

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7 January 2021

Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice

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7 January 2021

Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation

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7 January 2021

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human huntington disease gene

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7 January 2021

Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock

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7 January 2021

Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme

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7 January 2021

Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

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7 January 2021

Inhibition of interleukin 1beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

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7 January 2021

Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion

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7 January 2021

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

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7 January 2021

Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control

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7 January 2021

Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosis

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7 January 2021

Functional Role of Caspase-1 and Caspase-3 in an ALS Transgenic Mouse Model

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7 January 2021

Oxidative damage and metabolic dysfunction in Huntington's disease: selective vulnerability of the basal ganglia.

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7 January 2021

Mitochondrial dysfunction in neurodegenerative disorders

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7 January 2021

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

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7 January 2021

Safety of long-term high-dose minocycline in the treatment of acne

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7 January 2021

Safety of minocycline for acne

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7 January 2021

Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme

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7 January 2021

Induction of nitric oxide synthase activity in rodent brain following middle cerebral artery occlusion

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7 January 2021

Heterogeneous topographic and cellular distribution of huntingtin expression in the normal human neostriatum.

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7 January 2021

Identifiers

DOI

10.1038/77528

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29 July 2017

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