Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects (Q33911298)

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English	Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

30 July 2017

Conditional ablation of the heparan sulfate-synthesizing enzyme Ext1 leads to dysregulation of bone morphogenic protein signaling and severe skeletal defects (English)

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Exostosin glycosyltransferase 1

1 reference

GOA release 2020-03-11

author name string

Yoshihiro Matsumoto

1

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Kazu Matsumoto

2

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Europe PubMed Central

PubMed publication ID

30 July 2017

Fumitoshi Irie

3

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

Jun-ichi Fukushi

4

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

William B Stallcup

5

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Europe PubMed Central

PubMed publication ID

30 July 2017

Yu Yamaguchi

6

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Europe PubMed Central

PubMed publication ID

30 July 2017

language of work or name

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publication date

19 April 2010

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Europe PubMed Central

PubMed publication ID

30 July 2017

Journal of Biological Chemistry

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Europe PubMed Central

PubMed publication ID

30 July 2017

285

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Europe PubMed Central

PubMed publication ID

30 July 2017

25

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

19227-19234

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2885201/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Proximal tibial osteochondromas in patients with fibrodysplasia ossificans progressiva

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Heparan sulphate proteoglycans fine-tune mammalian physiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Interactions between heparan sulfate and proteins: the concept of specificity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Microarray analyses of gene expression during chondrocyte differentiation identifies novel regulators of hypertrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Cellular and molecular interactions regulating skeletogenesis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Bmpr1a and Bmpr1b have overlapping functions and are essential for chondrogenesis in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Wnt/beta-catenin signaling is sufficient and necessary for synovial joint formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

VEGFA is necessary for chondrocyte survival during bone development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Mammalian Brain Morphogenesis and Midline Axon Guidance Require Heparan Sulfate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Heparan sulfate is required for bone morphogenetic protein-7 signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Developmental regulation of the growth plate

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Hereditary multiple exostoses and heparan sulfate polymerization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Functions of FGF signalling from the apical ectodermal ridge in limb development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Action range of BMP is defined by its N-terminal basic amino acid core

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Heparan sulfate proteoglycans retain Noggin at the cell surface: a potential mechanism for shaping bone morphogenetic protein gradients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Gene-trap mutagenesis: past, present and beyond

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Regulation of Wnt signaling and embryo patterning by an extracellular sulfatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

The whereabouts of a morphogen: direct evidence for short- and graded long-range activity of hedgehog signaling peptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Bone development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Inhibition of sonic hedgehog autoprocessing in cultured mammalian cells by sterol deprivation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

All for one and one for all: condensations and the initiation of skeletal development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Human bone morphogenetic protein 2 contains a heparin-binding site which modifies its biological activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Type X collagen gene expression in mouse chondrocytes immortalized by a temperature-sensitive simian virus 40 large tumor antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Hox genes and the evolution of vertebrate axial morphology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

5 July 2018

The link between heparan sulfate and hereditary bone disease: finding a function for the EXT family of putative tumor suppressor proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105338

21 January 2018

Expression of NG2 proteoglycan during endochondral and intramembranous ossification

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105338

21 January 2018

Teleost HoxD and HoxA genes: comparison with tetrapods and functional evolution of the HOXD complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105338

21 January 2018

Ext1-dependent heparan sulfate regulates the range of Ihh signaling during endochondral ossification

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105338

21 January 2018

All for one and one for all: condensations and the initiation of skeletal development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105338

21 January 2018

Overexpression of BMP-2 and BMP-4 alters the size and shape of developing skeletal elements in the chick limb

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105338

21 January 2018

Conditional inactivation of Fgfr1 in mouse defines its role in limb bud establishment, outgrowth and digit patterning.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105338

21 January 2018

Role of BMP-2 and OP-1 (BMP-7) in programmed cell death and skeletogenesis during chick limb development.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2885201

29 October 2018

Sonic hedgehog and Fgf-4 act through a signaling cascade and feedback loop to integrate growth and patterning of the developing limb bud

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M110.105338

21 January 2018

BMPs are required at two steps of limb chondrogenesis: formation of prechondrogenic condensations and their differentiation into chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20404326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of Cre recombinase in the developing mouse limb bud driven by aPrxl enhancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/20404326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bmp4 in limb bud mesoderm regulates digit pattern by controlling AER development

1 reference

https://pubmed.ncbi.nlm.nih.gov/20404326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heparan sulfate proteoglycans including syndecan-3 modulate BMP activity during limb cartilage differentiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20404326

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.105338

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

30 July 2017

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