Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis (Q33925651)

30 July 2017

title

Anti-ADAMTS5 monoclonal antibodies: implications for aggrecanase inhibition in osteoarthritis (English)

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30 July 2017

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Suneel S Apte

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30 July 2017

language of work or name

English

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publication date

1 January 2016

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30 July 2017

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30 July 2017

volume

473

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30 July 2017

issue

1

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30 July 2017

page(s)

e1-4

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Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)

30 July 2017

cites work

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Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification

5 July 2018

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5 July 2018

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Current and emerging therapeutic strategies for preventing inflammation and aggrecanase-mediated cartilage destruction in arthritis

5 July 2018

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5 July 2018

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Targeting of ADAMTS5's ancillary domain with the recombinant mAb CRB0017 ameliorates disease progression in a spontaneous murine model of osteoarthritis

5 July 2018

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The different roles of aggrecan interaction domains

5 July 2018

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5 July 2018

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Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease

5 July 2018

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Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling

5 July 2018

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5 July 2018

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5 July 2018

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A disintegrin-like and metalloprotease (reprolysin-type) with thrombospondin type 1 motif (ADAMTS) superfamily: functions and mechanisms

5 July 2018

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Adamts5, the gene encoding a proteoglycan-degrading metalloprotease, is expressed by specific cell lineages during mouse embryonic development and in adult tissues.

5 July 2018

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5 July 2018

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5 July 2018

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Will the real aggrecanase(s) step up: evaluating the criteria that define aggrecanase activity in osteoarthritis.

5 July 2018

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Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity

5 July 2018

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Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5

5 July 2018

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High resolution crystal structure of the catalytic domain of ADAMTS-5 (aggrecanase-2)

5 July 2018

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Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair

5 July 2018

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Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.

5 July 2018

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Aggrecan degradation in human articular cartilage explants is mediated by both ADAMTS-4 and ADAMTS-5.

5 July 2018

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Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V

5 July 2018

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ADAMTS5 is the major aggrecanase in mouse cartilage in vivo and in vitro

5 July 2018

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Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

5 July 2018

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Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13.

5 July 2018

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Sites of aggrecan cleavage by recombinant human aggrecanase-1 (ADAMTS-4)

5 July 2018

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ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases. General features and genomic distribution of the ADAM-TS family

5 July 2018

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Cloning and characterization of ADAMTS11, an aggrecanase from the ADAMTS family

5 July 2018

1 reference

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Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins

5 July 2018

1 reference

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Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints

5 July 2018

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Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain

5 July 2018

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Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5525052

The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5525052

Fibronectin fragments cause release and degradation of collagen-binding molecules from equine explant cultures.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5525052

Aggrecan protects cartilage collagen from proteolytic cleavage

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5525052

Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5525052

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)

29 October 2018

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12 December 2020

Aggregation of cartilage proteoglycans. I. The role of hyaluronic acid

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12 December 2020

Generation and characterization of aggrecanase. A soluble, cartilage-derived aggrecan-degrading activity

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12 December 2020

Analysis of the catabolism of aggrecan in cartilage explants by quantitation of peptides from the three globular domains

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12 December 2020

Fibronectin fragments cause chondrolysis of bovine articular cartilage slices in culture

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12 December 2020

Isolation and characterization of proteoglycans

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12 December 2020

Identifiers

DOI

10.1042/BJ20151072

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30 July 2017

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30 July 2017

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