α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry. (Q33926400)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24960410%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

title

α-Synuclein-induced membrane remodeling is driven by binding affinity, partition depth, and interleaflet order asymmetry (English)

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21 March 2020

1 reference

2

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21 March 2020

author name string

Anthony R Braun

1

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21 March 2020

Vanessa C Ducas

3

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21 March 2020

Elizabeth Rhoades

4

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21 March 2020

Jonathan N Sachs

5

1 reference

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21 March 2020

language of work or name

English

0 references

publication date

7 July 2014

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Journal of the American Chemical Society

21 March 2020

published in

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21 March 2020

volume

136

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21 March 2020

issue

28

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21 March 2020

page(s)

9962-9972

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GROMACS 4: Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

21 March 2020

cites work

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5 July 2018

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5 July 2018

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5 July 2018

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Membrane curvature sensing by amphipathic helices: a single liposome study using α-synuclein and annexin B12

5 July 2018

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Determination of electron density profiles and area from simulations of undulating membranes.

5 July 2018

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5 July 2018

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Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein alpha-synuclein

5 July 2018

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5 July 2018

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Effects of Curvature and Composition on α-Synuclein Binding to Lipid Vesicles

5 July 2018

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Direct Simulation of Protein-Mediated Vesicle Fusion: Lung Surfactant Protein B

5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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5 July 2018

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Amphipathic motifs in BAR domains are essential for membrane curvature sensing

5 July 2018

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New insights into BAR domain-induced membrane remodeling

5 July 2018

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Simulations of membrane tubulation by lattices of amphiphysin N-BAR domains

5 July 2018

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5 July 2018

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The influence of vesicle size and composition on alpha-synuclein structure and stability

5 July 2018

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Alpha-synuclein binds large unilamellar vesicles as an extended helix

5 July 2018

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Clustering of alpha-synuclein on supported lipid bilayers: role of anionic lipid, protein, and divalent ion concentration

5 July 2018

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Curvature dynamics of alpha-synuclein familial Parkinson disease mutants: molecular simulations of the micelle- and bilayer-bound forms

5 July 2018

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Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement

5 July 2018

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Four-scale description of membrane sculpting by BAR domains

5 July 2018

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The hydrophobic insertion mechanism of membrane curvature generation by proteins

5 July 2018

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5 July 2018

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5 July 2018

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A general amphipathic alpha-helical motif for sensing membrane curvature.

5 July 2018

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5 July 2018

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Direct observation of Bin/amphiphysin/Rvs (BAR) domain-induced membrane curvature by means of molecular dynamics simulations

5 July 2018

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5 July 2018

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Structure and dynamics of micelle-bound human alpha-synuclein

5 July 2018

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A broken alpha -helix in folded alpha -Synuclein

5 July 2018

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5 July 2018

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Characterization of a novel protein regulated during the critical period for song learning in the zebra finch.

5 July 2018

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Spontaneous tubulation of membranes and vesicles reveals membrane tension generated by spontaneous curvature.

5 July 2018

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Nigrostriatal overabundance of α-synuclein leads to decreased vesicle density and deficits in dopamine release that correlate with reduced motor activity.

29 October 2018

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The amphipathic helix of an enzyme that regulates phosphatidylcholine synthesis remodels membranes into highly curved nanotubules.

29 October 2018

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Interleaflet interaction and asymmetry in phase separated lipid bilayers: molecular dynamics simulations

29 October 2018

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Membrane-bound alpha-synuclein forms an extended helix: long-distance pulsed ESR measurements using vesicles, bicelles, and rodlike micelles

29 October 2018

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Role of helix 0 of the N-BAR domain in membrane curvature generation.

29 October 2018

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29 October 2018

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Tilted properties of the 67-78 fragment of α-synuclein are responsible for membrane destabilization and neurotoxicity

29 October 2018

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12 December 2020

Membrane-bound structure and energetics of alpha-synuclein

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12 December 2020

Modulation of the spontaneous curvature and bending rigidity of lipid membranes by interfacially adsorbed amphipathic peptides

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Is lipid translocation involved during endo- and exocytosis?

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Probing conformational change of intrinsically disordered α-synuclein to helical structures by distinctive regional interactions with lipid membranes

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How curved membranes recruit amphipathic helices and protein anchoring motifs

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Identifiers

DOI

10.1021/JA5016958

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24960410%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24960410%20AND%20SRC:MED&resulttype=core&format=json

21 March 2020

PubMed publication ID

24960410

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24960410%20AND%20SRC:MED&resulttype=core&format=json