Functional characterization of BRCA1 and BRCA2: clues from their interacting proteins (Q33923818)

30 July 2017

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title

Functional characterization of BRCA1 and BRCA2: clues from their interacting proteins (English)

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30 July 2017

S K Sharan

1

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30 July 2017

A Bradley

series ordinal

2

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30 July 2017

language of work or name

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1 October 1998

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Journal of Mammary Gland Biology and Neoplasia

30 July 2017

published in

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30 July 2017

volume

3

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30 July 2017

issue

4

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30 July 2017

page(s)

413-421

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The BRC repeats in BRCA2 are critical for RAD51 binding and resistance to methyl methanesulfonate treatment

30 July 2017

cites work

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12 December 2020

The nuclear localization sequences of the BRCA1 protein interact with the importin-alpha subunit of the nuclear transport signal receptor

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12 December 2020

Helical interactions in homologous pairing and strand exchange driven by RecA protein

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12 December 2020

Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication

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12 December 2020

Identification of a novel cytoplasmic protein that specifically binds to nuclear localization signal motifs

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12 December 2020

S phase specific formation of the human Rad51 protein nuclear foci in lymphocytes

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12 December 2020

Mouse Brca1: localization sequence analysis and identification of evolutionarily conserved domains

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12 December 2020

Variation of risks of breast and ovarian cancer associated with different germline mutations of the BRCA2 gene

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12 December 2020

Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium

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12 December 2020

Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

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12 December 2020

Cell cycle-dependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains

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12 December 2020

A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53

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12 December 2020

The BRC repeats are conserved in mammalian BRCA2 proteins

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12 December 2020

RAB22 and RAB163/mouse BRCA2: proteins that specifically interact with the RAD51 protein

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12 December 2020

Location of BRCA1 in human breast and ovarian cancer cells

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12 December 2020

Rad51 protein involved in repair and recombination in S. cerevisiae is a RecA-like protein

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12 December 2020

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12 December 2020

Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA

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12 December 2020

BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases

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12 December 2020

BRCA1 is a component of the RNA polymerase II holoenzyme

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12 December 2020

Induction of phosphorylation on BRCA1 during the cell cycle and after DNA damage

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12 December 2020

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

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12 December 2020

Transcriptional activation by BRCA1

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12 December 2020

Detection of eight BRCA1 mutations in 10 breast/ovarian cancer families, including 1 family with male breast cancer

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12 December 2020

Murine Brca1: sequence and significance for human missense mutations

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12 December 2020

Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal phenotypes of Brca1, Brca2, Brca1/Brca2, Brca1/p53, and Brca2/p53 nullizygous embryos

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12 December 2020

Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage

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12 December 2020

Involvement of Brca2 in DNA repair

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12 December 2020

Internal repeats in the BRCA2 protein sequence

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12 December 2020

Inactivation of the mouse Brca1 gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development.

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12 December 2020

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

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12 December 2020

Murine Brca2: sequence, map position, and expression pattern

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12 December 2020

Developmental expression of Brca2 colocalizes with Brca1 and is associated with proliferation and differentiation in multiple tissues

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12 December 2020

Human Rad51 protein promotes ATP-dependent homologous pairing and strand transfer reactions in vitro

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12 December 2020

Cloning, chromosomal mapping and expression pattern of the mouse Brca2 gene

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12 December 2020

Human BRCA1 inhibits growth in yeast: potential use in diagnostic testing

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12 December 2020

BRCA1 is a 220-kDa nuclear phosphoprotein that is expressed and phosphorylated in a cell cycle-dependent manner

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12 December 2020

RAD51 interacts with the evolutionarily conserved BRC motifs in the human breast cancer susceptibility gene brca2

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12 December 2020

Breast cancer genes--what are the real risks?

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12 December 2020

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

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12 December 2020

Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families

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12 December 2020

Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation

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12 December 2020

DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

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12 December 2020

From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

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12 December 2020

BRCA1 is secreted and exhibits properties of a granin

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12 December 2020

Cancer-susceptibility genes. Gatekeepers and caretakers

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12 December 2020

Identification of a BRCA1-associated kinase with potential biological relevance.

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12 December 2020

A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins

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12 December 2020

The developmental pattern of Brca1 expression implies a role in differentiation of the breast and other tissues

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12 December 2020

Does this have a familiar RING?

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12 December 2020

Identification of a RING protein that can interact in vivo with the BRCA1 gene product

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12 December 2020

Isolation of the mouse homologue of BRCA1 and genetic mapping to mouse chromosome 11.

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12 December 2020

Distinct functions for the two importin subunits in nuclear protein import

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12 December 2020

Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelope

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12 December 2020

BRCA1 is a cell cycle-regulated nuclear phosphoprotein

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12 December 2020

Antisense RNA to the putative tumor suppressor gene BRCA1 transforms mouse fibroblasts.

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12 December 2020

Nuclear location and cell cycle regulation of the BRCA2 protein

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12 December 2020

BRCA1 protein products ... Functional motifs...

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12 December 2020

Response: Location of BRCA1 in Human Breast and Ovarian Cancer Cells

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12 December 2020

Nucleocytoplasmic transport

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12 December 2020

Association of BRCA1 with Rad51 in mitotic and meiotic cells

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12 December 2020

Linkage of early-onset familial breast cancer to chromosome 17q21

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12 December 2020

Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers

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12 December 2020

Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein

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12 December 2020

Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer

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12 December 2020

Multiple possible sites of BRCA2 interacting with DNA repair protein RAD51

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12 December 2020

Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells

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12 December 2020

Brca2 is required for embryonic cellular proliferation in the mouse

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12 December 2020

The complete BRCA2 gene and mutations in chromosome 13q-linked kindreds

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12 December 2020

Expression of Brca1 is associated with terminal differentiation of ectodermally and mesodermally derived tissues in mice

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12 December 2020

Transcriptional activation functions in BRCA2

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12 December 2020

Evidence for a transcriptional activation function of BRCA1 C-terminal region

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12 December 2020

Identifiers

DOI

10.1023/A:1018788132560

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Dimensions Publication ID

30 July 2017

1021088623

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