Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers (Q33979799)

30 July 2017

title

Pharmacokinetics and safety of AMD-3100, a novel antagonist of the CXCR-4 chemokine receptor, in human volunteers (English)

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30 July 2017

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C W Hendrix

1

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30 July 2017

C Flexner

2

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30 July 2017

R T MacFarland

3

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30 July 2017

C Giandomenico

4

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30 July 2017

E J Fuchs

5

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30 July 2017

E Redpath

6

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30 July 2017

G Bridger

7

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30 July 2017

G W Henson

8

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30 July 2017

language of work or name

English

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publication date

1 June 2000

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Antimicrobial Agents and Chemotherapy

30 July 2017

published in

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30 July 2017

volume

44

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30 July 2017

issue

6

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30 July 2017

page(s)

1667-1673

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Chemokine receptor antagonists: novel therapeutics for inflammation and AIDS.

30 July 2017

cites work

1 reference

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5 July 2018

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V3 recombinants indicate a central role for CCR5 as a coreceptor in tissue infection by human immunodeficiency virus type 1.

5 July 2018

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Activity of different bicyclam derivatives against human immunodeficiency virus depends on their interaction with the CXCR4 chemokine receptor

5 July 2018

1 reference

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The human immunodeficiency virus (HIV)-type 1 coreceptor CXCR-4 (fusin) is preferentially expressed on the more immature CD34+ hematopoietic stem cells

5 July 2018

1 reference

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Determinants for sensitivity of human immunodeficiency virus coreceptor CXCR4 to the bicyclam AMD3100

5 July 2018

1 reference

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Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1 alpha is mediated by the chemokine receptor CXCR4.

5 July 2018

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Chemokines and leukocyte traffic

5 July 2018

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AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

5 July 2018

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Analysis of the temporal relationship between human immunodeficiency virus type 1 quasispecies in sequential blood samples and various organs obtained at autopsy

5 July 2018

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Expression and function of CCR5 and CXCR4 on human Langerhans cells and macrophages: implications for HIV primary infection

5 July 2018

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Inhibition of T-tropic HIV strains by selective antagonization of the chemokine receptor CXCR4

5 July 2018

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CXCR-4 (Fusin), a co-receptor for the type 1 human immunodeficiency virus (HIV-1), is expressed in the human brain in a variety of cell types, including microglia and neurons.

5 July 2018

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Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4.

5 July 2018

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A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

5 July 2018

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In vivo compartmentalization of human immunodeficiency virus: evidence from the examination of pol sequences from autopsy tissues

5 July 2018

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CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons

5 July 2018

1 reference

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The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilization of CD34+ progenitors to peripheral blood.

5 July 2018

1 reference

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Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry

5 July 2018

1 reference

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Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry

5 July 2018

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CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1

5 July 2018

1 reference

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HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5

5 July 2018

1 reference

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Identification of a major co-receptor for primary isolates of HIV-1

5 July 2018

1 reference

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Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89930

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=89930

Toward improved anti-HIV chemotherapy: therapeutic strategies for intervention with HIV infections

5 July 2018

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Human immunodeficiency virus type 1 variants with increased replicative capacity develop during the asymptomatic stage before disease progression

5 July 2018

1 reference

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Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex

5 July 2018

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Distinct replicative and cytopathic characteristics of human immunodeficiency virus isolates

5 July 2018

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Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population

5 July 2018

1 reference

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Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines

5 July 2018

1 reference

12 December 2020

Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4

1 reference

12 December 2020

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA

1 reference

12 December 2020

Chemokine receptor CXCR4 expression in endothelium

1 reference

12 December 2020

10.1128/AAC.44.6.1667-1673.2000

Identifiers

DOI

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30 July 2017

1 reference

30 July 2017

1 reference