A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis (Q33995709)

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English	A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis	scientific article

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scholarly article

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30 July 2017

A farnesyltransferase inhibitor induces tumor regression in transgenic mice harboring multiple oncogenic mutations by mediating alterations in both cell cycle control and apoptosis (English)

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30 July 2017

apoptotic process

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David J. Bearss

9

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30 July 2017

author name string

Barrington RE

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30 July 2017

Subler MA

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30 July 2017

Rands E

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30 July 2017

Omer CA

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30 July 2017

Miller PJ

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30 July 2017

Hundley JE

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30 July 2017

Koester SK

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30 July 2017

Troyer DA

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30 July 2017

Conner MW

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30 July 2017

Gibbs JB

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30 July 2017

Hamilton K

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30 July 2017

Koblan KS

13

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30 July 2017

Mosser SD

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O'Neill TJ

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30 July 2017

Schaber MD

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30 July 2017

Senderak ET

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30 July 2017

Windle JJ

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30 July 2017

Oliff A

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Kohl NE

20

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language of work or name

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publication date

1 January 1998

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30 July 2017

Molecular and Cellular Biology

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30 July 2017

18

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30 July 2017

1

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30 July 2017

85-92

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30 July 2017

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Farnesyl transferase inhibitors induce apoptosis of Ras-transformed cells denied substratum attachment.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

E2F-1 cooperates with topoisomerase II inhibition and DNA damage to selectively augment p53-independent apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Increased tumor proliferation and genomic instability without decreased apoptosis in MMTV-ras mice deficient in p53

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

An information-intensive approach to the molecular pharmacology of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

The p53 tumour suppressor gene: a mediator of a G1 growth arrest and of apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Protein prenylation: molecular mechanisms and functional consequences

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Cancer therapy and p53.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Evidence that farnesyltransferase inhibitors suppress Ras transformation by interfering with Rho activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

The multistep nature of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Susceptibility to apoptosis is differentially regulated by c-myc and mutated Ha-ras oncogenes and is associated with endonuclease availability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

PxF, a prenylated protein of peroxisomes.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Database of p53 gene somatic mutations in human tumors and cell lines

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Constitutive expression of the c-H-ras oncogene inhibits doxorubicin-induced apoptosis and promotes cell survival in a rhabdomyosarcoma cell line

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Introduction of an activated N-ras oncogene alters the growth characteristics of the interleukin 6-dependent myeloma cell line ANBL6.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Activated H-ras rescues E1A-induced apoptosis and cooperates with E1A to overcome p53-dependent growth arrest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

p53-independent death and p53-induced protection against apoptosis in fibroblasts treated with chemotherapeutic drugs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Mutation and cancer: statistical study of retinoblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

The ras gene family and human carcinogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

All ras proteins are polyisoprenylated but only some are palmitoylated

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

ras oncogenes in human cancer: a review

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Ras C-terminal processing enzymes--new drug targets?

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Induction of apoptosis in fibroblasts by c-myc protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

5 July 2018

Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

29 October 2018

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

29 October 2018

p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=121456

29 October 2018

Differential regulation of cell cycle characteristics and apoptosis in MMTV-myc and MMTV-ras mouse mammary tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

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Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

p53 status and the efficacy of cancer therapy in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemotherapy of mammary carcinomas arising in ras transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A peptidomimetic inhibitor of farnesyl:protein transferase blocks the anchorage-dependent and -independent growth of human tumor cell lines

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of human tumor xenograft growth by treatment with the farnesyl transferase inhibitor B956

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activated N-ras contributes to the chemoresistance of human melanoma in severe combined immunodeficiency (SCID) mice by blocking apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/9418856

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1128/MCB.18.1.85

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Europe PubMed Central

PubMed publication ID

30 July 2017

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Europe PubMed Central

PubMed publication ID

30 July 2017

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

30 July 2017

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