Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching". (Q44089221)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

title

Rational cytokine design for increased lifetime and enhanced potency using pH-activated "histidine switching" (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

B Tidor

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Douglas A. Lauffenburger

6

object named as

Douglas A Lauffenburger

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

author name string

Casim A Sarkar

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Thomas Horan

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Thomas C Boone

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

language of work or name

1 reference

5 August 2002

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

volume

20

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

issue

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

page(s)

908-913

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12161759%20AND%20SRC:MED&resulttype=core&format=json

Two mutant alleles of the insulin receptor gene in a family with a genetic form of insulin resistance: a 10 base pair deletion in exon 1 and a mutation substituting serine for asparagine-462.

11 November 2019

cites work

1 reference

Alternative intracellular routing of ErbB receptors may determine signaling potency

21 January 2018

1 reference

Controlling receptor/ligand trafficking: Effects of cellular and molecular properties on endosomal sorting

21 January 2018

1 reference

Engineering epidermal growth factor for enhanced mitogenic potency

21 January 2018

1 reference

Increased endosomal sorting of ligand to recycling enhances potency of an interleukin-2 analog

21 January 2018

1 reference

Dimerization of the extracellular domain of granuloycte-colony stimulating factor receptor by ligand binding: a monovalent ligand induces 2:2 complexes

21 January 2018

1 reference

Dimerization of granulocyte-colony stimulating factor receptor: the Ig plus CRH construct of granulocyte-colony stimulating factor receptor forms a 2:2 complex with a ligand.

21 January 2018

1 reference

Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme

21 January 2018

1 reference

1H-NMR study on the tautomerism of the imidazole ring of histidine residues. I. Microscopic pK values and molar ratios of tautomers in histidine-containing peptides

21 January 2018

1 reference

On the pH dependence of protein stability.

21 January 2018

1 reference

Interaction of granulocyte colony-stimulating factor (G-CSF) with its receptor. Evidence that Glu19 of G-CSF interacts with Arg288 of the receptor

21 January 2018

1 reference

Identification of residues critical to the activity of human granulocyte colony-stimulating factor

21 January 2018

1 reference

Computational model for effects of ligand/receptor binding properties on interleukin-2 trafficking dynamics and T cell proliferation response.

21 January 2018

1 reference

21 January 2018

The Protein Data Bank

1 reference

Identification of ligand-binding site III on the immunoglobulin-like domain of the granulocyte colony-stimulating factor receptor.

21 January 2018

1 reference

Polar hydrogen positions in proteins: Empirical energy placement and neutron diffraction comparison

21 January 2018

1 reference

CHARMM: A program for macromolecular energy, minimization, and dynamics calculations

21 January 2018

1 reference

Backbone-dependent rotamer library for proteins. Application to side-chain prediction

21 January 2018

1 reference

Exploring the conformational space of protein side chains using dead-end elimination and the A* algorithm

21 January 2018

1 reference

Efficient rotamer elimination applied to protein side-chains and related spin glasses

21 January 2018

1 reference

Electrostatic interactions in the GCN4 leucine zipper: substantial contributions arise from intramolecular interactions enhanced on binding

21 January 2018

1 reference

Electrostatic interactions in macromolecules: theory and applications

21 January 2018

1 reference

Expression and dynamic modulation of the human granulocyte colony-stimulating factor receptor in immature and differentiated myeloid cells

21 January 2018

1 reference

Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons

21 January 2018

1 reference

Scratching the (cell) surface: cytokine engineering for improved ligand/receptor trafficking dynamics

21 January 2018

1 reference

The dead-end elimination theorem and its use in protein side-chain positioning

21 January 2018

1 reference

Calculation of electrostatic potentials in an enzyme active site

21 January 2018

1 reference

Intracellular trafficking of epidermal growth factor family ligands is directly influenced by the pH sensitivity of the receptor/ligand interaction

21 January 2018

1 reference

7 January 2021

Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes

1 reference

7 January 2021

Identification of a ligand-binding site on the granulocyte colony-stimulating factor receptor by molecular modeling and mutagenesis

1 reference

7 January 2021

Kinetic analysis of receptor-mediated endocytosis of G-CSF derivative, nartograstim, in rat bone marrow cells

1 reference

7 January 2021