Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex (Q44255903)

1 December 2017

title

Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex (English)

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1 December 2017

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Kalergis AM

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1 December 2017

Doucey MA

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1 December 2017

Palmieri E

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Goyarts EC

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1 December 2017

Vegh Z

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1 December 2017

Luescher IF

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Nathenson SG

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1 December 2017

language of work or name

English

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publication date

1 March 2001

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1 December 2017

number of pages

6

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inferred from page(s)

published in

Nature Immunology

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1 December 2017

volume

2

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1 December 2017

issue

3

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1 December 2017

page(s)

229-234

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Alloreactivity, antigen recognition and T-cell selection: three diverse T-cell recognition problems with a common solution

1 December 2017

cites work

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Structural basis of T cell recognition

21 January 2018

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Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton

21 January 2018

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Serial triggering of many T-cell receptors by a few peptide-MHC complexes

21 January 2018

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Ligand recognition by alpha beta T cell receptors

21 January 2018

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Breaking the affinity ceiling for antibodies and T cell receptors

21 January 2018

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Kinetic proofreading in T-cell receptor signal transduction

21 January 2018

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Kinetic discrimination in T-cell activation

21 January 2018

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The immunological synapse: a molecular machine controlling T cell activation

21 January 2018

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Fidelity of T cell activation through multistep T cell receptor zeta phosphorylation

21 January 2018

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T-cell-receptor affinity and thymocyte positive selection

21 January 2018

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Peptide antagonism and T cell receptor interactions with peptide-MHC complexes

21 January 2018

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Effects of epitope modification on T cell receptor-ligand binding and antigen recognition by seven H-2Kd-restricted cytotoxic T lymphocyte clones specific for a photoreactive peptide derivative

21 January 2018

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A functional hot spot for antigen recognition in a superagonist TCR/MHC complex

21 January 2018

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Conversion of a T cell antagonist into an agonist by repairing a defect in the TCR/peptide/MHC interface: implications for TCR signaling.

21 January 2018

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On defining the rules for interactions between the T cell receptor and its ligand: a critical role for a specific amino acid residue of the T cell receptor beta chain

21 January 2018

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Isolation of an endogenously processed immunodominant viral peptide from the class I H–2Kb molecule

21 January 2018

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Diversity of T cell receptors specific for the VSV antigenic peptide (N52-59) bound by the H-2Kb class I molecule

21 January 2018

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Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule

21 January 2018

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Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative

21 January 2018

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Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing

21 January 2018

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T cell recognition of hapten. Anatomy of T cell receptor binding of a H-2kd-associated photoreactive peptide derivative.

21 January 2018

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In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

21 January 2018

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Role of CD8 in aberrant function of cytotoxic T lymphocytes

21 January 2018

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T cell affinity maturation by selective expansion during infection

21 January 2018

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A kinetic basis for T cell receptor repertoire selection during an immune response

21 January 2018

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Selection of highly transfectable variant from mouse mastocytoma P815.

21 January 2018

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Mapping the orientation of an antigenic peptide bound in the antigen binding groove of H-2Kb using a monoclonal antibody.

21 January 2018

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Essential Role of CD8 Palmitoylation in CD8 Coreceptor Function

21 January 2018

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Detection of antigen-specific T cells with multivalent soluble class II MHC covalent peptide complexes

21 January 2018

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From TCR Engagement to T Cell Activation

21 January 2018

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Progression of autoimmune diabetes driven by avidity maturation of a T-cell population

21 January 2018

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Serine esterase in cytolytic T lymphocytes

21 January 2018

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Evidence that a single peptide-MHC complex on a target cell can elicit a cytolytic T cell response

21 January 2018

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7 January 2021

Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex proteins

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7 January 2021

High- and low-potency ligands with similar affinities for the TCR: the importance of kinetics in TCR signaling

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7 January 2021

Point mutations in the beta chain CDR3 can alter the T cell receptor recognition pattern on an MHC class I/peptide complex over a broad interface area

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7 January 2021

A simplified procedure for the preparation of MHC/peptide tetramers: chemical biotinylation of an unpaired cysteine engineered at the C-terminus of MHC-I

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7 January 2021

Altered peptide ligand-mediated TCR antagonism can be modulated by a change in a single amino acid residue within the CDR3 beta of an MHC class I-restricted TCR

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7 January 2021

Identifiers

DOI

10.1038/85286

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Dimensions Publication ID

1 December 2017

1002780739

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