Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema (Q44360463)

2 December 2017

title

Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema (English)

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2 December 2017

3

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2 December 2017

David G Morris

1

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2 December 2017

Xiaozhu Huang

2

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2 December 2017

Yanli Wang

4

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2 December 2017

Steven D Shapiro

5

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2 December 2017

Gregory Dolganov

6

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2 December 2017

Adam Glick

7

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2 December 2017

Dean Sheppard

8

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2 December 2017

language of work or name

English

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publication date

1 March 2003

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2 December 2017

number of pages

5

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inferred from page(s)

published in

Nature

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2 December 2017

volume

422

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2 December 2017

issue

6928

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2 December 2017

page(s)

169-173

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Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis

2 December 2017

cites work

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A point mutation in the integrin beta 6 subunit abolishes both alpha v beta 6 binding to fibronectin and receptor localization to focal contacts

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Expression of the human integrin beta6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in beta6 knockout mice

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Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice

21 January 2018

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21 January 2018

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21 January 2018

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Conditional epidermal expression of TGFbeta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia

21 January 2018

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A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects

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The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis

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TGF-beta is a critical mediator of acute lung injury

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7 January 2021

Elastase secretion by stimulated macrophages. Characterization and regulation

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7 January 2021

Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice

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7 January 2021

The alpha v beta 6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain

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7 January 2021

Inactivation of the integrin beta 6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin

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7 January 2021

Overexpression of tumor necrosis factor-alpha produces an increase in lung volumes and pulmonary hypertension

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7 January 2021

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema

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7 January 2021

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

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7 January 2021

Pathologic changes in the peripheral airways of young cigarette smokers

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7 January 2021

Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin alpha v beta 6 to focal contacts

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7 January 2021

FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo.

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7 January 2021

Quantitative methods in the study of pulmonary pathology

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7 January 2021

Identifiers

DOI

10.1038/NATURE01413

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Dimensions Publication ID

2 December 2017

1030984562

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