Reconstitution of gamma-secretase activity (Q44393107)

2 December 2017

title

Reconstitution of gamma-secretase activity (English)

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6

Christian Haass

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Joerg T Regula

object named as

Joerg T Regula

3

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Dieter Edbauer

1

object named as

Dieter Edbauer

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2 December 2017

Edith Winkler

2

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2 December 2017

Brigitte Pesold

4

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Harald Steiner

5

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publication date

1 May 2003

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2 December 2017

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2 December 2017

volume

5

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2 December 2017

issue

5

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2 December 2017

page(s)

486-488

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Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases

2 December 2017

cites work

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7 January 2021

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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7 January 2021

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

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7 January 2021

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

1 reference

7 January 2021

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

1 reference

7 January 2021

APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes

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7 January 2021

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

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7 January 2021

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

1 reference

7 January 2021

Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

1 reference

7 January 2021

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

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7 January 2021

An in vivo assay for the identification of target proteases which cleave membrane-associated substrates

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7 January 2021

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

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7 January 2021

Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

1 reference

7 January 2021

Characterization of a presenilin-mediated amyloid precursor protein carboxyl-terminal fragment gamma. Evidence for distinct mechanisms involved in gamma -secretase processing of the APP and Notch1 transmembrane domains

1 reference

7 January 2021

Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch

1 reference

7 January 2021

Identifiers

DOI

10.1038/NCB960

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2 December 2017

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