The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors (Q44420427)

2 December 2017

title

The mechanism of gamma-secretase: multiple inhibitor binding sites for transition state analogs and small molecule inhibitors (English)

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2 December 2017

Gaochao Tian

1

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2 December 2017

Smita V Ghanekar

2

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2 December 2017

David Aharony

3

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2 December 2017

Ashok B Shenvi

4

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2 December 2017

Robert T Jacobs

5

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2 December 2017

Xiaodong Liu

6

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2 December 2017

Barry D Greenberg

7

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2 December 2017

language of work or name

English

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publication date

28 April 2003

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Journal of Biological Chemistry

2 December 2017

published in

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2 December 2017

volume

278

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2 December 2017

issue

31

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2 December 2017

page(s)

28968-28975

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Gamma-secretase: never more enigmatic

2 December 2017

cites work

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Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1

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21 January 2018

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21 January 2018

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A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions

21 January 2018

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21 January 2018

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Linear non-competitive inhibition of solubilized human gamma-secretase by pepstatin A methylester, L685458, sulfonamides, and benzodiazepines

21 January 2018

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L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity

21 January 2018

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Activity-dependent isolation of the presenilin- gamma -secretase complex reveals nicastrin and a gamma substrate

21 January 2018

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

21 January 2018

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A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

21 January 2018

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gamma-Secretase, evidence for multiple proteolytic activities and influence of membrane positioning of substrate on generation of amyloid beta peptides of varying length

21 January 2018

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Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.M300905200

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2 December 2017

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