A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity (Q44452050)

3 December 2017

title

A modular PIP2 binding site as a determinant of capsaicin receptor sensitivity (English)

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3 December 2017

2

David Julius

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3 December 2017

Elizabeth D Prescott

1

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3 December 2017

language of work or name

English

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publication date

1 May 2003

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3 December 2017

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3 December 2017

volume

300

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3 December 2017

issue

5623

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3 December 2017

page(s)

1284-1288

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Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

3 December 2017

cites work

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Receptor-mediated hydrolysis of plasma membrane messenger PIP2 leads to K+-current desensitization

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Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide

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Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma

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The capsaicin receptor: a heat-activated ion channel in the pain pathway

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Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia

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Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia

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Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions

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Induction of vanilloid receptor channel activity by protein kinase C

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Regulation of TRP channels via lipid second messengers.

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Impaired nociception and pain sensation in mice lacking the capsaicin receptor

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The TRPM7 channel is inactivated by PIP(2) hydrolysis

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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

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Chromaffin granule-associated phosphatidylinositol 4-kinase activity is required for stimulated secretion.

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A heat-sensitive TRP channel expressed in keratinocytes

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The cloned capsaicin receptor integrates multiple pain-producing stimuli

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Direct phosphorylation of capsaicin receptor VR1 by protein kinase Cepsilon and identification of two target serine residues

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Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

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Identifiers

DOI

10.1126/SCIENCE.1083646

1 reference

3 December 2017

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