Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance (Q44804450)

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scientific article published on December 1, 1977

Language	Label	Description	Also known as
English	Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance	scientific article published on December 1, 1977

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A599411

14 July 2022

author name string

K. S. Pang

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A599411

14 July 2022

M. Rowland

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A599411

14 July 2022

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publication date

1 December 1977

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Europe PubMed Central

PubMed publication ID

6 December 2017

Journal of Pharmacokinetics and Pharmacodynamics

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

5

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

6

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

625-653

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

STUDIES OF UREA EXCRETION. II: Relationship Between Urine Volume and the Rate of Urea Excretion by Normal Adults

1 reference

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Influence of First-Pass Effect on Availability of Drugs on Oral Administration

1 reference

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Influence of route of administration on drug availability

1 reference

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Pharmacokinetics of Drug Disposition: Hemodynamic Considerations

1 reference

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Clearance concepts in pharmacokinetics

1 reference

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Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey. Relative contributions of enzyme induction and increased hepatic blood flow

1 reference

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Commentary: a physiological approach to hepatic drug clearance

1 reference

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Effect of Plasma Protein Binding on Elimination of Warfarin

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The effect of the upright posture upon hepatic blood flow in normotensive and hypertensive subjects

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Interrelationships of Hepatic Blood Flow, Cardiac Output, and Blood Levels of Lidocaine in Man

1 reference

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Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

1 reference

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Nonlinear Tissue Disposition: Salicylic Acid in Rat Brain

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Blood Levels of Drug at the Equilibrium State after Multiple Dosing

1 reference

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21 January 2018

Clearance and biologic half-life as indices of intrinsic hepatic metabolism

1 reference

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12 December 2020

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Absorption kinetics of aspirin in man following oral administration of an aqueous solution

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disposition of propranolol. 8. General implications of the effects of liver blood flow on elimination from the perfused rat liver

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Capillary-tissue exchange kinetics: diffusional interactions between adjacent capillaries

1 reference

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based on heuristic

inferred from PubMed ID database lookup

Perfusion-limited of plasma drug binding on hepatic drug extraction

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic elimination kinetics: the influence of hepatic blood flow on clearance determination

1 reference

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The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog

1 reference

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Hepatic vascular bed.

1 reference

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inferred from PubMed ID database lookup

Michaelis-Menten kinetics of galactose elimination by the isolated perfused pig liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

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The gastric secretion of drugs: a pH partition hypothesis

1 reference

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The disposition of propranolol. I. Elimination during oral absorption in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

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based on heuristic

inferred from PubMed ID database lookup

Concentration of propoxyphene in human plasma following oral, intramuscular, and intravenous administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

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based on heuristic

inferred from PubMed ID database lookup

Effects of route of administration and blood flow on hepatic drug elimination

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulatory pathways in the rat liver as revealed by P32 chromic phosphate colloid uptake in the isolated perfused liver preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Defective bromosulfophthalein clearance in patients with constitutional hepatic dysfunction (Gilbert's syndrome)

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic elimination of substrates flowing through the intact liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oral absorption and disposition kinetics of lidocaine hydrochloride in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiochemical properties, solubility, and protein binding of delta9-tetrahydrocannabinol

1 reference

https://pubmed.ncbi.nlm.nih.gov/599411

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01059688

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

6 December 2017

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